Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations

doi:10.1007/s13238-013-0002-3

Protein Cell

2014, Vol. 5

Issue (1) : 21-35 https://doi.org/10.1007/s13238-013-0002-3 PMID: 24474199

REVIEW

Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations

Fang Hu,Feng Liu(

)

Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha 410011, China

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Abstract

It has been well established that most of the age-related diseases such as insulin resistance, type 2 diabetes, hypertension, cardiovascular disease, osteoporosis, and atherosclerosis are all closely related to metabolic dysfunction. On the other hand, interventions on metabolism such as calorie restriction or genetic manipulations of key metabolic signaling pathways such as the insulin and mTOR signaling pathways slow down the aging process and improve healthy aging. These findings raise an important question as to whether improving energy homeostasis by targeting certain metabolic signaling pathways in specific tissues could be an effective anti-aging strategy. With a more comprehensive understanding of the tissue-specific roles of distinct metabolic signaling pathways controlling energy homeostasis and the cross-talks between these pathways during aging may lead to the development of more effective therapeutic interventions not only for metabolic dysfunction but also for aging.

Keywords aging metabolic disease insulin mTOR caloric restriction

Corresponding Author(s): Feng Liu

Issue Date: 16 May 2014

Cite this article:

Fang Hu,Feng Liu. Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations[J]. Protein Cell, 2014, 5(1): 21-35.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-013-0002-3
https://academic.hep.com.cn/pac/EN/Y2014/V5/I1/21

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