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“RADIOTRANSCRIPTOMICS”: A synergy of imaging and transcriptomics in clinical assessment |
Amal Katrib1,*( ),William Hsu2,Alex Bui2,Yi Xing1,*( ) |
1. Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles CA 90095, USA
2. Department of Radiological Sciences, University of California, Los Angeles, Los Angeles, CA 90095, USA |
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Abstract Recent advances in quantitative imaging and “omics” technology have generated a wealth of mineable biological “big data”. With the push towards a P4 “predictive, preventive, personalized, and participatory” approach to medicine, researchers began integrating complementary tools to further tune existing diagnostic and therapeutic models. The field of radiogenomics has long pioneered such multidisciplinary investigations in neuroscience and oncology, correlating genotypic and phenotypic signatures to study structural and functional changes in relation to altered molecular behavior. Given the innate dynamic nature of complex disorders and the role of environmental and epigenetic factors in pathogenesis, the transcriptome can further elucidate serial modifications undetected at the genome level. We therefore propose “radiotranscriptomics” as a new member of the P4 medicine initiative, combining transcriptome information, including gene expression and isoform variation, and quantitative image annotations.
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Author Summary
The wealth of publically available “big data” has promoted a paradigm shift in medical research, emphasizing the need for multi-disciplinary integrative efforts to tackle chronic and complex disorders. By coupling molecular indexes from transcriptomics and phenotypic traits from imaging, “radiotranscriptomics” can provide a keener insight into the molecular and functional alterations behind chronic and multifactorial disorders. |
Keywords
quantitative imaging
transcriptomics
RNA-seq
genomics
image genomics
radiogenomics
systems biology
precision medicine
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Fund: |
Corresponding Author(s):
Amal Katrib,Yi Xing
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Online First Date: 16 March 2016
Issue Date: 16 March 2016
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