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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2012, Vol. 6 Issue (4) : 376-380     DOI: 10.1007/s11684-012-0228-0
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
Fung Zhao, Eric W.-F. Lam()
Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK
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The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords FOXO3a      FOXM1      transcription factor      cancer      drug resistance      tumorigenesis     
Corresponding Authors: Lam Eric W.-F.,   
Issue Date: 05 December 2012
URL:     OR
Fig.1  Integration of signals with FOXO and FOXM1 axis upon stimulation of chemotherapeutic drugs. Hemotherapeutic drugs have various modes of action but ultimately integrate signals with the PI3K-AKT-FOXO-FOXM1 signaling cascade. FOXO and FOXM1 then exert antagonistic functions in the regulation of target genes, which in turn control cancer-related processes including drug resistance, angiogenesis and migration.
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