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Novel aspects of the apolipoprotein-E receptor family: regulation and functional role of their proteolytic processing |
Jorge A. LARIOS1,2, Maria-Paz MARZOLO1,2() |
1. Laboratorio de Tráfico Intracelular y Se?alización, Departamento de Biología Celular y Molecular, Pontificia Universidad Católica de Chile, Alameda # 340, Santiago, Chile; 2. Millenium Nucleus in Regenerative Biology (MINREB), Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Alameda # 340, Santiago, Chile |
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Abstract Studies related to the functional and regulatory aspects of proteolytic processing are of interest to cell biologists, developmental biologists and investigators who work on human diseases. Much of what is known about this topic derives from the study of the proteolytic processing of the amyloid precursor protein (APP), which is involved in the pathology of Alzheimer’s disease, and of the Notch protein and its Delta ligand, which play roles during embryonic development and in biologic processes in the adult. The proteolytic processing of plasma membrane receptor proteins is under the control of different enzymes that are responsible for releasing the ectodomain into the extracellular environment, where it has the potential to function as a signaling molecule and/or regulate the availability of the receptor’s ligand. Following shedding of the ectodomain, the γ-secretase enzymatic complex cleaves the transmembrane domain and releases the cytoplasmic domain (ICD) of the receptor. The ICD can function in the cytoplasm and/or at the nucleus. Members of the low-density lipoprotein receptor (LDLR) family are endocytic-signaling proteins that perform a wide variety of physiologic functions during development and in the adult life. In addition these receptors have been implicated in a variety of diseases in adults. The prototypic receptor for this family of proteins is the LDLR itself. Besides their binding to apolipoproteins, these receptors bind many ligands that are destined for internalization and degradation. Some ligands have signaling properties. The proteolytic processing of certain members of the LDLR family not only controls receptor availability at the cell surface but also has functional consequences that amplify the spectrum of roles that these receptors perform. In addition, many complex regulatory mechanisms control the proteolytic processing of these receptors.
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Keywords
ADAM
APP
LDLR
LRP
metalloproteinase
secretase
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Corresponding Author(s):
MARZOLO Maria-Paz,Email:mmarzolo@bio.puc.cl
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Issue Date: 01 April 2012
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|
1 |
Abe J, Deguchi J, Matsumoto T, Takuwa N, Noda M, Ohno M, Makuuchi M, Kurokawa K, Takuwa Y (1997). Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening. Circulation , 96(6): 1906–1913 pmid:9323080
|
2 |
Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997). beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J , 16(13): 3797–3804 doi: 10.1093/emboj/16.13.3797 pmid:9233789
|
3 |
Agholme F, Aspenberg P (2011). Wnt signaling and orthopedics, an overview. Acta Orthop , 82(2): 125–130 doi: 10.3109/17453674.2011.572252 pmid:21438671
|
4 |
Alvira-Botero X, Pérez-Gonzalez R, Spuch C, Vargas T, Antequera D, Garzón M, Bermejo-Pareja F, Carro E (2010). Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. Mol Cell Neurosci , 45(3): 306–315 doi: 10.1016/j.mcn.2010.07.005 pmid:20637285
|
5 |
Ambj?rn M, Asmussen J W, Lindstam M, Gotfryd K, Jacobsen C, Kiselyov V V, Moestrup S K, Penkowa M, Bock E, Berezin V (2008). Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family. J Neurochem , 104(1): 21–37 pmid:17986228
|
6 |
An J, Zhang C, Polavarapu R, Zhang X, Zhang X, Yepes M (2008). Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein induce Akt phosphorylation in the ischemic brain. Blood , 112(7): 2787–2794 doi: 10.1182/blood-2008-02-141630 pmid:18628488
|
7 |
Andrade N, Komnenovic V, Blake S M, Jossin Y, Howell B, Goffinet A, Schneider W J, Nimpf J (2007). ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci USA , 104(20): 8508–8513 doi: 10.1073/pnas.0611391104 pmid:17494763
|
8 |
Andreasen P A, Sottrup-Jensen L, Kj?ller L, Nykjaer A, Moestrup S K, Petersen C M, Gliemann J (1994). Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes. FEBS Lett , 338(3): 239–245 doi: 10.1016/0014-5793(94)80276-9 pmid:8307187
|
9 |
Arnaud L, Ballif B A, F?rster E, Cooper J A (2003). Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol , 13(1): 9–17 doi: 10.1016/S0960-9822(02)01397-0 pmid:12526739
|
10 |
Assadi A H, Zhang G, Beffert U, McNeil R S, Renfro A L, Niu S, Quattrocchi C C, Antalffy B A, Sheldon M, Armstrong D D, Wynshaw-Boris A, Herz J, D’Arcangelo G, Clark G D (2003). Interaction of reelin signaling and Lis1 in brain development. Nat Genet , 35(3): 270–276 . Epub 2003 Oct 2026.
|
11 |
Assémat E, Chatelet F, Chandellier J, Commo F, Cases O, Verroust P, Kozyraki R (2005). Overlapping expression patterns of the multiligand endocytic receptors cubilin and megalin in the CNS, sensory organs and developing epithelia of the rodent embryo. Gene Expr Patterns , 6(1): 69–78 doi: 10.1016/j.modgep.2005.04.014 pmid:16027047
|
12 |
Bachinsky D R, Zheng G, Niles J L, McLaughlin M, Abbate M, Andres G, Brown D, McCluskey R T (1993). Detection of two forms of GP330. Their role in Heymann nephritis. Am J Pathol , 143(2): 598–611 pmid:8342605
|
13 |
Baker R N, Cancilla P A, Pollock P S, Frommes S P (1971). The movement of exogenous protein in experimental cerebral edema. An electron microscopic study after freeze-injury. J Neuropathol Exp Neurol , 30(4): 668–679 doi: 10.1097/00005072-197110000-00010 pmid:5135018
|
14 |
Ballif B A, Arnaud L, Arthur W T, Guris D, Imamoto A, Cooper J A (2004). Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol , 14(7): 606–610 doi: 10.1016/j.cub.2004.03.038 pmid:15062102
|
15 |
Ballif B A, Arnaud L, Cooper J A (2003). Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases. Brain Res Mol Brain Res , 117(2): 152–159 doi: 10.1016/S0169-328X(03)00295-X pmid:14559149
|
16 |
Bansal A, Gierasch L M (1991). The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation. Cell , 67(6): 1195–1201 doi: 10.1016/0092-8674(91)90295-A pmid:1760844
|
17 |
Bar I, Goffinet A M (1999). Developmental neurobiology. Decoding the Reelin signal. Nature , 399(6737): 645–646 doi: 10.1038/21340 pmid:10385113
|
18 |
Barker T H, Pallero M A, MacEwen M W, Tilden S G, Woods A, Murphy-Ullrich J E, Hagood J S (2004). Thrombospondin-1-induced focal adhesion disassembly in fibroblasts requires Thy-1 surface expression, lipid raft integrity, and Src activation. J Biol Chem , 279(22): 23510–23516 doi: 10.1074/jbc.M402169200 pmid:15033989
|
19 |
Barnes H, Ackermann E J, van der Geer P (2003). v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1. Oncogene , 22(23): 3589–3597 doi: 10.1038/sj.onc.1206504 pmid:12789267
|
20 |
Barnes H, Larsen B, Tyers M, van Der Geer P (2001). Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells. J Biol Chem , 276(22): 19119–19125 pmid:11259429
|
21 |
Barth J L, Argraves W S (2001). Cubilin and megalin: partners in lipoprotein and vitamin metabolism. Trends Cardiovasc Med , 11(1): 26–31 doi: 10.1016/S1050-1738(01)00080-9 pmid:11413049
|
22 |
Basu S, Binder R J, Ramalingam T, Srivastava P K (2001). CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin. Immunity , 14(3): 303–313 doi: 10.1016/S1074-7613(01)00111-X pmid:11290339
|
23 |
Beagle B, Mi K, Johnson G V (2009). Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/beta-catenin pathway and attenuate GSK3beta activity. J Cell Biochem , 108(4): 886–895 doi: 10.1002/jcb.22318 pmid:19711366
|
24 |
Beffert U, Durudas A, Weeber E J, Stolt P C, Giehl K M, Sweatt J D, Hammer R E, Herz J (2006). Functional dissection of Reelin signaling by site-directed disruption of disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci , 26(7): 2041–2052 doi: 10.1523/JNEUROSCI.4566-05.2006 pmid:16481437
|
25 |
Beffert U, Morfini G, Bock H H, Reyna H, Brady S T, Herz J (2002). Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta. J Biol Chem , 277(51): 49958–49964 doi: 10.1074/jbc.M209205200 pmid:12376533
|
26 |
Beffert U, Weeber E J, Durudas A, Qiu S, Masiulis I, Sweatt J D, Li W P, Adelmann G, Frotscher M, Hammer R E, Herz J (2005). Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron , 47(4): 567–579 doi: 10.1016/j.neuron.2005.07.007 pmid:16102539
|
27 |
Behrens J, Lustig B (2004). The Wnt connection to tumorigenesis. Int J Dev Biol , 48(5-6): 477–487 doi: 10.1387/ijdb.041815jb pmid:15349822
|
28 |
Beisiegel U, Weber W, Ihrke G, Herz J, Stanley K K (1989). The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature , 341(6238): 162–164 doi: 10.1038/341162a0 pmid:2779654
|
29 |
Betts G N, van der Geer P, Komives E A (2008). Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain. J Biol Chem , 283(23): 15656–15664 doi: 10.1074/jbc.M709514200 pmid:18381291
|
30 |
Biemesderfer D (2006). Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule? Kidney Int , 69(10): 1717–1721 doi: 10.1038/sj.ki.5000298 pmid:16557231
|
31 |
Bilic J, Huang Y L, Davidson G, Zimmermann T, Cruciat C M, Bienz M, Niehrs C (2007). Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science , 316(5831): 1619–1622 doi: 10.1126/science.1137065 pmid:17569865
|
32 |
Binder R J, Han D K, Srivastava P K (2000). CD91: a receptor for heat shock protein gp96. Nat Immunol , 1(2): 151–155 doi: 10.1038/77835 pmid:11248808
|
33 |
Binder R J, Srivastava P K (2004). Essential role of CD91 in re-presentation of gp96-chaperoned peptides. Proc Natl Acad Sci USA , 101(16): 6128–6133 doi: 10.1073/pnas.0308180101 pmid:15073331
|
34 |
Birk H W, Piberhofer S, Schütterle G, Haase W, K?tting J, Koepsell H (1991). Analysis of Na+-D-glucose cotransporter and other renal brush border proteins in human urine. Kidney Int , 40(5): 823–837 doi: 10.1038/ki.1991.282 pmid:1762286
|
35 |
Blake S M, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider W J, Nimpf J (2008). Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J , 27(22): 3069–3080 doi: 10.1038/emboj.2008.223 pmid:18946489
|
36 |
Blaumueller C M, Qi H, Zagouras P, Artavanis-Tsakonas S (1997). Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell , 90(2): 281–291 doi: 10.1016/S0092-8674(00)80336-0 pmid:9244302
|
37 |
Bock H H, Herz J (2003). Reelin activates SRC family tyrosine kinases in neurons. Curr Biol , 13(1): 18–26 doi: 10.1016/S0960-9822(02)01403-3 pmid:12526740
|
38 |
Bock H H, Jossin Y, Liu P, Forster E, May P, Goffinet A M, Herz J (2003). Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. J Biol Chem , 278(40): 38772–38779
|
39 |
Boucher P, Gotthardt M, Li W P, Anderson R G, Herz J (2003). LRP: role in vascular wall integrity and protection from atherosclerosis. Science , 300(5617): 329–332 doi: 10.1126/science.1082095 pmid:12690199
|
40 |
Boucher P, Liu P, Gotthardt M, Hiesberger T, Anderson R G, Herz J (2002). Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae. J Biol Chem , 277(18): 15507–15513 doi: 10.1074/jbc.M200428200 pmid:11854295
|
41 |
Boutros M, Paricio N, Strutt D I, Mlodzik M (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell , 94(1): 109–118 doi: 10.1016/S0092-8674(00)81226-X pmid:9674432
|
42 |
Bovenschen N, Mertens K, Hu L, Havekes L M, van Vlijmen B J (2005). LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood , 106(3): 906–912 doi: 10.1182/blood-2004-11-4230 pmid:15840700
|
43 |
Brannon M, Gomperts M, Sumoy L, Moon R T, Kimelman D (1997). A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev , 11(18): 2359–2370 doi: 10.1101/gad.11.18.2359 pmid:9308964
|
44 |
Brown M S, Goldstein J L (1986). A receptor-mediated pathway for cholesterol homeostasis. Science , 232(4746): 34–47 doi: 3513311" target="_blank">10.1126/science. pmid:3513311 pmid:3513311
|
45 |
Bryja V, Andersson E R, Schambony A, Esner M, Bryjová L, Biris K K, Hall A C, Kraft B, Cajanek L, Yamaguchi T P, Buckingham M, Arenas E (2008). The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell , 20(3): 924–936 doi: 10.1091/mbc.E08-07-0711 pmid:19056682
|
46 |
Bu G, Cam J, Zerbinatti C (2006). LRP in amyloid-beta production and metabolism. Ann N Y Acad Sci , 1086(1): 35–53 doi: 10.1196/annals.1377.005 pmid:17185504
|
47 |
Bu G, Maksymovitch E A, Schwartz A L (1993). Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells. J Biol Chem , 268(17): 13002–13009 pmid:8389767
|
48 |
Bu G, Marzolo M P (2000). Role of rap in the biogenesis of lipoprotein receptors. Trends Cardiovasc Med , 10(4): 148–155 doi: 10.1016/S1050-1738(00)00045-1 pmid:11239794
|
49 |
Bu G, Morton P A, Schwartz A L (1992a). Identification and partial characterization by chemical cross-linking of a binding protein for tissue-type plasminogen activator (t-PA) on rat hepatoma cells. A plasminogen activator inhibitor type 1-independent t-PA receptor. J Biol Chem , 267(22): 15595–15602 pmid:1322401
|
50 |
Bu G, Schwartz A L (1998). RAP, a novel type of ER chaperone. Trends Cell Biol , 8(7): 272–276 doi: 10.1016/S0962-8924(98)01283-5 pmid:9714598
|
51 |
Bu G, Warshawsky I, Schwartz A L (1994). Cellular receptors for the plasminogen activators. Blood , 83(12): 3427–3436 pmid:8204869
|
52 |
Bu G, Williams S, Strickland D K, Schwartz A L (1992b). Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci USA , 89(16): 7427–7431 doi: 10.1073/pnas.89.16.7427 pmid:1502154
|
53 |
Burstyn-Cohen T, Frumkin A, Xu Y T, Scherer S S, Klar A (1998). Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons. J Neurosci , 18(21): 8875–8885 pmid:9786993
|
54 |
Buxbaum J D, Liu K N, Luo Y, Slack J L, Stocking K L, Peschon J J, Johnson R S, Castner B J, Cerretti D P, Black R A (1998). Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor. J Biol Chem , 273(43): 27765–27767 doi: 10.1074/jbc.273.43.27765 pmid:9774383
|
55 |
Cajánek L, Ribeiro D, Liste I, Parish C L, Bryja V, Arenas E (2009). Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells , 27(12): 2917–2927 pmid:19725118
|
56 |
Cam J A, Zerbinatti C V, Knisely J M, Hecimovic S, Li Y, Bu G (2004). The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. J Biol Chem , 279(28): 29639–29646 doi: 10.1074/jbc.M313893200 pmid:15126508
|
57 |
Cao C, Lawrence D A, Li Y, Von Arnim C A, Herz J, Su E J, Makarova A, Hyman B T, Strickland D K, Zhang L (2006). Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J , 25(9): 1860–1870 doi: 10.1038/sj.emboj.7601082 pmid:16601674
|
58 |
Cao X, Südhof T C (2001). A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science , 293(5527): 115–120 doi: 10.1126/science.1058783 pmid:11441186
|
59 |
Caporaso G L, Gandy S E, Buxbaum J D, Ramabhadran T V, Greengard P (1992). Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proc Natl Acad Sci USA , 89(7): 3055–3059 doi: 10.1073/pnas.89.7.3055 pmid:1557413
|
60 |
Carro E, Spuch C, Trejo J L, Antequera D, Torres-Aleman I (2005). Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J Neurosci , 25(47): 10884–10893 doi: 10.1523/JNEUROSCI.2909-05.2005 pmid:16306401
|
61 |
Caruso-Neves C, Pinheiro A A, Cai H, Souza-Menezes J, Guggino W B (2006). PKB and megalin determine the survival or death of renal proximal tubule cells. Proc Natl Acad Sci USA , 103(49): 18810–18815 doi: 10.1073/pnas.0605029103 pmid:17121993
|
62 |
Cerpa W, Toledo E M, Varela-Nallar L, Inestrosa N C (2009). The role of Wnt signaling in neuroprotection. Drug News Perspect , 22(10): 579–591 doi: 10.1358/dnp.2009.22.10.1443391 pmid:20140278
|
63 |
Chai X, F?rster E, Zhao S, Bock H H, Frotscher M (2009a). Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci , 29(1): 288–299 doi: 10.1523/JNEUROSCI.2934-08.2009 pmid:19129405
|
64 |
Chai X, F?rster E, Zhao S, Bock H H, Frotscher M (2009b). Reelin acts as a stop signal for radially migrating neurons by inducing phosphorylation of n-cofilin at the leading edge. Commun Integr Biol , 2(4): 375–377 doi: 10.4161/cib.2.4.8614 pmid:19721896
|
65 |
Chazaud B, Ricoux R, Christov C, Plonquet A, Gherardi R K, Barlovatz-Meimon G (2002). Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations. Am J Pathol , 160(1): 237–246 doi: 10.1016/S0002-9440(10)64367-2 pmid:11786417
|
66 |
Chen C D, Podvin S, Gillespie E, Leeman S E, Abraham C R (2007). Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA , 104(50): 19796–19801 doi: 10.1073/pnas.0709805104 pmid:18056631
|
67 |
Cho S Y, Jeon J W, Lee S H, Park S S (2000). p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells. Biochem J , 352(3): 645–650 doi: 10.1042/0264-6021:3520645 pmid:11104669
|
68 |
Christ A, Terryn S, Schmidt V, Christensen E I, Huska M R, Andrade-Navarro M A, Hübner N, Devuyst O, Hammes A, Willnow T E (2010). The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo. Kidney Int , 78(5): 473–477 doi: 10.1038/ki.2010.169 pmid:20531455
|
69 |
Christensen E I, Birn H, Verroust P, Moestrup S K (1998). Megalin-mediated endocytosis in renal proximal tubule. Ren Fail , 20(2): 191–199 doi: 10.3109/08860229809045102 pmid:9574443
|
70 |
Christensen E I, Moskaug J O, Vorum H, Jacobsen C, Gundersen T E, Nykjaer A, Blomhoff R, Willnow T E, Moestrup S K (1999). Evidence for an essential role of megalin in transepithelial transport of retinol. J Am Soc Nephrol , 10(4): 685–695 pmid:10203351
|
71 |
Christian J L, Gavin B J, McMahon A P, Moon R T (1991). Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development. Dev Biol , 143(2): 230–234 doi: 10.1016/0012-1606(91)90073-C pmid:1991549
|
72 |
Christie R H, Chung H, Rebeck G W, Strickland D, Hyman B T (1996). Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer’s disease. J Neuropathol Exp Neurol , 55(4): 491–498 doi: 10.1097/00005072-199604000-00012 pmid:8786409
|
73 |
Christoffersen C, Dahlb?ck B, Nielsen L B (2006). Apolipoprotein M: progress in understanding its regulation and metabolic functions. Scand J Clin Lab Invest , 66(7): 631–638 doi: 10.1080/00365510600885500 pmid:17101555
|
74 |
Chun J T, Wang L, Pasinetti G M, Finch C E, Zlokovic B V (1999). Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol , 157(1): 194–201 doi: 10.1006/exnr.1999.7052 pmid:10222122
|
75 |
Chung R S, Penkowa M, Dittmann J, King C E, Bartlett C, Asmussen J W, Hidalgo J, Carrasco J, Leung Y K, Walker A K, Fung S J, Dunlop S A, Fitzgerald M, Beazley L D, Chuah M I, Vickers J C, West A K (2008). Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem , 283(22): 15349–15358 doi: 10.1074/jbc.M708446200 pmid:18334482
|
76 |
Congote L F (2007). Serpin A1 and CD91 as host instruments against HIV-1 infection: are extracellular antiviral peptides acting as intracellular messengers? Virus Res , 125(2): 119–134 doi: 10.1016/j.virusres.2006.12.018 pmid:17258834
|
77 |
Cselenyi C S, Jernigan K K, Tahinci E, Thorne C A, Lee L A, Lee E (2008). LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3’s phosphorylation of beta-catenin. Proc Natl Acad Sci USA , 105(23): 8032–8037 doi: 10.1073/pnas.0803025105 pmid:18509060
|
78 |
Cui S, Verroust P J, Moestrup S K, Christensen E I (1996). Megalin/gp330 mediates uptake of albumin in renal proximal tubule. Am J Physiol , 271(4 Pt 2): F900–F907 pmid:8898021
|
79 |
Cuitino L, Matute R, Retamal C, Bu G, Inestrosa N C, Marzolo M P (2005). ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts’ association. Traffic , 6(9): 820–838 doi: 10.1111/j.1600-0854.2005.00320.x pmid:16101684
|
80 |
Culi J, Mann R S (2003). Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell , 112(3): 343–354 doi: 10.1016/S0092-8674(02)01279-5 pmid:12581524
|
81 |
Culi J, Springer T A, Mann R S (2004). Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J , 23(6): 1372–1380 doi: 10.1038/sj.emboj.7600132 pmid:15014448
|
82 |
Czekay R P, Aertgeerts K, Curriden S A, Loskutoff D J (2003). Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins. J Cell Biol , 160(5): 781–791 doi: 10.1083/jcb.200208117 pmid:12615913
|
83 |
Czekay R P, Orlando R A, Woodward L, Lundstrom M, Farquhar M G (1997). Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. Mol Biol Cell , 8(3): 517–532 pmid:9188102
|
84 |
D’Arcangelo G, Homayouni R, Keshvara L, Rice D S, Sheldon M, Curran T (1999). Reelin is a ligand for lipoprotein receptors. Neuron , 24(2): 471–479 doi: 10.1016/S0896-6273(00)80860-0 pmid:10571240
|
85 |
Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C (2005). Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature , 438(7069): 867–872 doi: 10.1038/nature04170 pmid:16341016
|
86 |
De Ferrari G V, Inestrosa N C (2000). Wnt signaling function in Alzheimer’s disease. Brain Res Brain Res Rev , 33(1): 1–12 doi: 10.1016/S0165-0173(00)00021-7 pmid:10967351
|
87 |
Dedieu S, Langlois B, Devy J, Sid B, Henriet P, Sartelet H, Bellon G, Emonard H, Martiny L (2008). LRP-1 silencing prevents malignant cell invasion despite increased pericellular proteolytic activities. Mol Cell Biol , 28(9): 2980–2995 doi: 10.1128/MCB.02238-07 pmid:18316405
|
88 |
Del Río J A, Heimrich B, Borrell V, F?rster E, Drakew A, Alcántara S, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Derer P, Frotscher M, Soriano E (1997). A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature , 385(6611): 70–74 doi: 10.1038/385070a0 pmid:8985248
|
89 |
Delarasse C, Auger R, Gonnord P, Fontaine B, Kanellopoulos J M (2011). The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein. J Biol Chem , 286(4): 2596–2606 doi: 10.1074/jbc.M110.200618 pmid:21081501
|
90 |
Díaz-Rodríguez E, Montero J C, Esparís-Ogando A, Yuste L, Pandiella A (2002). Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell , 13(6): 2031–2044 doi: 10.1091/mbc.01-11-0561 pmid:12058067
|
91 |
Dietrich M F, van der Weyden L, Prosser H M, Bradley A, Herz J, Adams D J (2010). Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS ONE , 5(4): e9960 doi: 10.1371/journal.pone.0009960 pmid:20383322
|
92 |
Duit S, Mayer H, Blake S M, Schneider W J, Nimpf J (2010). Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors. J Biol Chem , 285(7): 4896–4908 doi: 10.1074/jbc.M109.025973 pmid:19948739
|
93 |
Edwards D R, Handsley M M, Pennington C J (2008). The ADAM metalloproteinases. Mol Aspects Med , 29(5): 258–289 doi: 10.1016/j.mam.2008.08.001 pmid:18762209
|
94 |
Emonard H, Bellon G, de Diesbach P, Mettlen M, Hornebeck W, Courtoy P J (2005). Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an “old friend”. Biochimie , 87(3-4): 369–376 doi: 10.1016/j.biochi.2004.11.013 pmid:15781324
|
95 |
Emonard H, Bellon G, Troeberg L, Berton A, Robinet A, Henriet P, Marbaix E, Kirkegaard K, Patthy L, Eeckhout Y, Nagase H, Hornebeck W, Courtoy P J (2004). Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. J Biol Chem , 279(52): 54944–54951 doi: 10.1074/jbc.M406792200 pmid:15489233
|
96 |
Endo K, Takino T, Miyamori H, Kinsen H, Yoshizaki T, Furukawa M, Sato H (2003). Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem , 278(42): 40764–40770 doi: 10.1074/jbc.M306736200 pmid:12904296
|
97 |
Erdmann K S, Mao Y, McCrea H J, Zoncu R, Lee S, Paradise S, Modregger J, Biemesderfer D, Toomre D, De Camilli P (2007). A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway. Dev Cell , 13(3): 377–390 doi: 10.1016/j.devcel.2007.08.004 pmid:17765681
|
98 |
Erranz B, Miquel J F, Argraves W S, Barth J L, Pimentel F, Marzolo M P (2004). Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids. J Lipid Res , 45(12): 2185–2198 doi: 10.1194/jlr.M400235-JLR200 pmid:15375181
|
99 |
Espirito Santo S M, Pires N M, Boesten L S, Gerritsen G, Bovenschen N, van Dijk K W, Jukema J W, Princen H M, Bensadoun A, Li W P, Herz J, Havekes L M, van Vlijmen B J (2004). Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol. Blood , 103(10): 3777–3782 doi: 10.1182/blood-2003-11-4051 pmid:14739216
|
100 |
Facciponte J G, MacDonald I J, Wang X Y, Kim H, Manjili M H, Subjeck J R (2005). Heat shock proteins and scavenger receptors: role in adaptive immune responses. Immunol Invest , 34(3): 325–342 doi: 10.1081/IMM-200064505 pmid:16136784
|
101 |
Fan H, Turck C W, Derynck R (2003). Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide. J Biol Chem , 278(20): 18617–18627 doi: 10.1074/jbc.M300331200 pmid:12621058
|
102 |
Fayard B, Bianchi F, Dey J, Moreno E, Djaffer S, Hynes N E, Monard D (2009). The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression. Cancer Res , 69(14): 5690–5698 doi: 10.1158/0008-5472.CAN-08-4573 pmid:19584287
|
103 |
Fears C Y, Gladson C L, Woods A (2006). Syndecan-2 is expressed in the microvasculature of gliomas and regulates angiogenic processes in microvascular endothelial cells. J Biol Chem , 281(21): 14533–14536 doi: 10.1074/jbc.C600075200 pmid:16574663
|
104 |
Feinstein Y, Borrell V, Garcia C, Burstyn-Cohen T, Tzarfaty V, Frumkin A, Nose A, Okamoto H, Higashijima S, Soriano E, Klar A (1999). F-spondin and mindin: two structurally and functionally related genes expressed in the hippocampus that promote outgrowth of embryonic hippocampal neurons. Development , 126(16): 3637–3648 pmid:10409509
|
105 |
Fisher C E, Howie S E (2006). The role of megalin (LRP-2/Gp330) during development. Dev Biol , 296(2): 279–297 doi: 10.1016/j.ydbio.2006.06.007 pmid:16828734
|
106 |
Fitzgerald M, Nairn P, Bartlett C A, Chung R S, West A K, Beazley L D (2007). Metallothionein-IIA promotes neurite growth via the megalin receptor. Exp Brain Res , 183(2): 171–180 doi: 10.1007/s00221-007-1032-y pmid:17634932
|
107 |
Fleming C E, Mar F M, Franquinho F, Saraiva M J, Sousa M M (2009). Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activity. J Neurosci , 29(10): 3220–3232 doi: 10.1523/JNEUROSCI.6012-08.2009 pmid:19279259
|
108 |
Fortini M E (2002). Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling. Nat Rev Mol Cell Biol , 3(9): 673–684 doi: 10.1038/nrm910 pmid:12209127
|
109 |
Fortini M E (2009). Notch signaling: the core pathway and its posttranslational regulation. Dev Cell , 16(5): 633–647 doi: 10.1016/j.devcel.2009.03.010 pmid:19460341
|
110 |
Frykman P K, Brown M S, Yamamoto T, Goldstein J L, Herz J (1995). Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci USA , 92(18): 8453–8457 doi: 10.1073/pnas.92.18.8453 pmid:7667310
|
111 |
Fuentealba R A, Barría M I, Lee J, Cam J, Araya C, Escudero C A, Inestrosa N C, Bronfman F C, Bu G, Marzolo M P (2007). ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener , 2(1): 14 doi: 10.1186/1750-1326-2-14 pmid:17620134
|
112 |
Fuentealba R A, Farias G, Scheu J, Bronfman M, Marzolo M P, Inestrosa N C (2004). Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease. Brain Res Brain Res Rev , 47(1-3): 275–289 doi: 10.1016/j.brainresrev.2004.07.018 pmid:15572177
|
113 |
Fuentealba R A, Liu Q, Kanekiyo T, Zhang J, Bu G (2009). Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. J Biol Chem , 284(49): 34045–34053 doi: 10.1074/jbc.M109.021030 pmid:19815552
|
114 |
Gajera C R, Emich H, Lioubinski O, Christ A, Beckervordersandforth-Bonk R, Yoshikawa K, Bachmann S, Christensen E I, G?tz M, Kempermann G, Peterson A S, Willnow T E, Hammes A (2010). LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci , 123(11): 1922–1930 doi: 10.1242/jcs.065912 pmid:20460439
|
115 |
Gallagher H, Oleinikov A V, Fenske C, Newman D J (2004). The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin. Biochimie , 86(3): 179–182 doi: 10.1016/j.biochi.2004.03.001 pmid:15134832
|
116 |
Garcia J H, Lossinsky A S, Kauffman F C, Conger K A (1978). Neuronal ischemic injury: light microscopy, ultrastructure and biochemistry. Acta Neuropathol , 43(1-2): 85–95 doi: 10.1007/BF00685002 pmid:97917
|
117 |
García-Miranda P, Peral M J, Ilundain A A (2010). Rat small intestine expresses the reelin-Disabled-1 signalling pathway. Exp Physiol , 95(4): 498–507 doi: 10.1113/expphysiol.2009.050682 pmid:19946030
|
118 |
Gardai S J, McPhillips K A, Frasch S C, Janssen W J, Starefeldt A, Murphy-Ullrich J E, Bratton D L, Oldenborg P A, Michalak M, Henson P M (2005). Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell , 123(2): 321–334 doi: 10.1016/j.cell.2005.08.032 pmid:16239148
|
119 |
Garton K J, Gough P J, Blobel C P, Murphy G, Greaves D R, Dempsey P J, Raines E W (2001). Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem , 276(41): 37993–38001 pmid:11495925
|
120 |
Gaultier A, Arandjelovic S, Li X, Janes J, Dragojlovic N, Zhou G P, Dolkas J, Myers R R, Gonias S L, Campana W M (2008). A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest , 118(1): 161–172 doi: 10.1172/JCI32371 pmid:18060043
|
121 |
Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala G, Akassoglou K, Campana W M, Gonias S L (2009). Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci , 122(8): 1155–1162 doi: 10.1242/jcs.040717 pmid:19299462
|
122 |
Gessert S, Kühl M (2010). The multiple phases and faces of wnt signaling during cardiac differentiation and development. Circ Res , 107(2): 186–199 doi: 10.1161/CIRCRESAHA.110.221531 pmid:20651295
|
123 |
Gil C, Cubí R, Aguilera J (2007). Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts. FEBS Lett , 581(9): 1851–1858 doi: 10.1016/j.febslet.2007.03.080 pmid:17433308
|
124 |
Goldstein J L, Brown M S, Anderson R G W, Russell D W, Schneider W J (1985). Receptor-mediated endocytosis: concepts emerging from the LDL receptor system. Annu Rev Cell Biol , 1(1): 1–39 doi: 10.1146/annurev.cb.01.110185.000245 pmid:2881559
|
125 |
Gonzalez-Villalobos R, Klassen R B, Allen P L, Johanson K, Baker C B, Kobori H, Navar L G, Hammond T G (2005). Megalin binds and internalizes angiotensin-(1-7). Am J Physiol Renal Physiol , 290(5): F1270–F1275 doi: 10.1152/ajprenal.00164.2005 pmid:16380466
|
126 |
Gonzalez-Villalobos R, Klassen R B, Allen P L, Navar L G, Hammond T G (2005). Megalin binds and internalizes angiotensin II. Am J Physiol Renal Physiol , 288(2): F420–F427 doi: 10.1152/ajprenal.00243.2004 pmid:15467006
|
127 |
Gorovoy M, Gaultier A, Campana W M, Firestein G S, Gonias S L (2010). Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol , 88(4): 769–778 doi: 10.1189/jlb.0410220 pmid:20610799
|
128 |
Gotthardt M, Trommsdorff M, Nevitt M F, Shelton J, Richardson J A, Stockinger W, Nimpf J, Herz J (2000). Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem , 275(33): 25616–25624 doi: 10.1074/jbc.M000955200 pmid:10827173
|
129 |
Greenwood J A, Murphy-Ullrich J E (1998). Signaling of de-adhesion in cellular regulation and motility. Microsc Res Tech , 43(5): 420–432 doi: 10.1002/(SICI)1097-0029(19981201)43:5<420::AID-JEMT8>3.0.CO;2-B pmid:9858339
|
130 |
Guénette S, Chang Y, Hiesberger T, Richardson J A, Eckman C B, Eckman E A, Hammer R E, Herz J (2006). Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J , 25(2): 420–431 doi: 10.1038/sj.emboj.7600926 pmid:16407979
|
131 |
Guénette S Y, Chang Y, Hyman B T, Tanzi R E, Rebeck G W (2002). Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem , 82(4): 755–762 doi: 10.1046/j.1471-4159.2002.01009.x pmid:12358780
|
132 |
Guo N, Hawkins C, Nathans J (2004). Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci USA , 101(25): 9277–9281 doi: 10.1073/pnas.0402802101 pmid:15169958
|
133 |
Guo Y, Zi X, Koontz Z, Kim A, Xie J, Gorlick R, Holcombe R F, Hoang B H (2007). Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells. J Orthop Res , 25(7): 964–971 doi: 10.1002/jor.20356 pmid:17318900
|
134 |
Guttman M, Betts G N, Barnes H, Ghassemian M, van der Geer P, Komives E A (2009). Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1. Proteomics , 9(22): 5016–5028 doi: 10.1002/pmic.200900457 pmid:19771558
|
135 |
Haas J, Beer A G, Widschwendter P, Oberdanner J, Salzmann K, Sarg B, Lindner H, Herz J, Patsch J R, Marschang P (2011). LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE—carrying lipoproteins. Atherosclerosis , 216(2): 342–347 doi: 10.1016/j.atherosclerosis.2011.02.030 pmid:21420681
|
136 |
Hack I, Hellwig S, Junghans D, Brunne B, Bock H H, Zhao S, Frotscher M (2007). Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development , 134(21): 3883–3891 doi: 10.1242/dev.005447 pmid:17913789
|
137 |
Hahn-Dantona E, Ruiz J F, Bornstein P, Strickland D K (2001). The low density lipoprotein receptor-related protein modulates levels of matrix metalloproteinase 9 (MMP-9) by mediating its cellular catabolism. J Biol Chem , 276(18): 15498–15503 doi: 10.1074/jbc.M100121200 pmid:11279011
|
138 |
Hama H, Saito A, Takeda T, Tanuma A, Xie Y, Sato K, Kazama J J, Gejyo F (2004). Evidence indicating that renal tubular metabolism of leptin is mediated by megalin but not by the leptin receptors. Endocrinology , 145(8): 3935–3940 doi: 10.1210/en.2004-0074 pmid:15131016
|
139 |
Hammad S M, Barth J L, Knaak C, Argraves W S (2000). Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem , 275(16): 12003–12008 doi: 10.1074/jbc.275.16.12003 pmid:10766831
|
140 |
Hammad S M, Ranganathan S, Loukinova E, Twal W O, Argraves W S (1997). Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem , 272(30): 18644–18649 doi: 10.1074/jbc.272.30.18644 pmid:9228033
|
141 |
Harris B, Pereira I, Parkin E (2009). Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein. Brain Res , 1296: 203–215 doi: 10.1016/j.brainres.2009.07.105 pmid:19679113
|
142 |
Hashimoto Y, Jiang H, Niikura T, Ito Y, Hagiwara A, Umezawa K, Abe Y, Murayama Y, Nishimoto I (2000). Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases. J Neurosci , 20(22): 8401–8409 pmid:11069947
|
143 |
Hay E, Faucheu C, Suc-Royer I, Touitou R, Stiot V, Vayssière B, Baron R, Roman-Roman S, Rawadi G (2005). Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway. J Biol Chem , 280(14): 13616–13623 doi: 10.1074/jbc.M411999200 pmid:15699046
|
144 |
Hayashida K, Bartlett A H, Chen Y, Park P W (2010). Molecular and cellular mechanisms of ectodomain shedding. Anat Rec (Hoboken) , 293(6): 925–937 doi: 10.1002/ar.20757 pmid:20503387
|
145 |
He X, Cooley K, Chung C H, Dashti N, Tang J (2007). Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production. J Neurosci , 27(15): 4052–4060 doi: 10.1523/JNEUROSCI.3993-06.2007 pmid:17428983
|
146 |
Hermo L, Lustig M, Lefrancois S, Argraves W S, Morales C R (1999). Expression and regulation of LRP-2/megalin in epithelial cells lining the efferent ducts and epididymis during postnatal development. Mol Reprod Dev , 53(3): 282–293 doi: 10.1002/(SICI)1098-2795(199907)53:3<282::AID-MRD4>3.0.CO;2-A pmid:10369389
|
147 |
Herz J, Chen Y (2006). Reelin, lipoprotein receptors and synaptic plasticity. Nat Rev Neurosci , 7(11): 850–859 doi: 10.1038/nrn2009 pmid:17053810
|
148 |
Herz J, Clouthier D E, Hammer R E (1992a). LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell , 71(3): 411–421 doi: 10.1016/0092-8674(92)90511-A pmid:1423604
|
149 |
Herz J, Clouthier D E, Hammer R E (1992b). LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell , 71(3): 411–421 doi: 10.1016/0092-8674(92)90511-A pmid:1423604
|
150 |
Herz J, Willnow T E (1994). Functions of the LDL receptor gene family. Ann N Y Acad Sci , 737: 14–19 doi: 10.1111/j.1749-6632.1994.tb44298.x pmid:7944143
|
151 |
Hiesberger T, Trommsdorff M, Howell B W, Goffinet A, Mumby M C, Cooper J A, Herz J (1999). Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron , 24(2): 481–489 doi: 10.1016/S0896-6273(00)80861-2 pmid:10571241
|
152 |
Higashijima S, Nose A, Eguchi G, Hotta Y, Okamoto H (1997). Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis. Dev Biol , 192(2): 211–227 doi: 10.1006/dbio.1997.8760 pmid:9441663
|
153 |
Higashiyama S, Nanba D (2005). ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta , 1751(1): 110–117 pmid:16054021
|
154 |
Hocevar B A, Mou F, Rennolds J L, Morris S M, Cooper J A, Howe P H (2003). Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J , 22(12): 3084–3094 doi: 10.1093/emboj/cdg286 pmid:12805222
|
155 |
Hocevar B A, Smine A, Xu X X, Howe P H (2001). The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J , 20(11): 2789–2801 doi: 10.1093/emboj/20.11.2789 pmid:11387212
|
156 |
Hoe H S, Cooper M J, Burns M P, Lewis P A, van der Brug M, Chakraborty G, Cartagena C M, Pak D T, Cookson M R, Rebeck G W (2007). The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis. J Neurosci , 27(40): 10895–10905 doi: 10.1523/JNEUROSCI.3135-07.2007 pmid:17913923
|
157 |
Hoe H S, Magill L A, Guenette S, Fu Z, Vicini S, Rebeck G W (2006a). FE65 interaction with the ApoE receptor ApoEr2. J Biol Chem , 281(34): 24521–24530 doi: 10.1074/jbc.M600728200 pmid:16638748
|
158 |
Hoe H S, Minami S S, Makarova A, Lee J, Hyman B T, Matsuoka Y, Rebeck G W (2008). Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem , 283(10): 6288–6299 doi: 10.1074/jbc.M704140200 pmid:18089558
|
159 |
Hoe H S, Pocivavsek A, Chakraborty G, Fu Z, Vicini S, Ehlers M D, Rebeck G W (2006b). Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem , 281(6): 3425–3431 doi: 10.1074/jbc.M509380200 pmid:16332682
|
160 |
Hoe H S, Rebeck G W (2005). Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res , 137(1-2): 31–39 doi: 10.1016/j.molbrainres.2005.02.013 pmid:15950758
|
161 |
Hoe H S, Tran T S, Matsuoka Y, Howell B W, Rebeck G W (2006c). DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing. J Biol Chem , 281(46): 35176–35185 doi: 10.1074/jbc.M602162200 pmid:16951405
|
162 |
Hoe H S, Wessner D, Beffert U, Becker A G, Matsuoka Y, Rebeck G W (2005). F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol Cell Biol , 25(21): 9259–9268 doi: 10.1128/MCB.25.21.9259-9268.2005 pmid:16227578
|
163 |
Hofmann S M, Zhou L, Perez-Tilve D, Greer T, Grant E, Wancata L, Thomas A, Pfluger P T, Basford J E, Gilham D, Herz J, Tsch?p M H, Hui D Y (2007). Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest , 117(11): 3271–3282 doi: 10.1172/JCI31929 pmid:17948131
|
164 |
Holmbeck K, Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov S A, Mankani M, Robey P G, Poole A R, Pidoux I, Ward J M, Birkedal-Hansen H (1999). MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell , 99(1): 81–92 doi: 10.1016/S0092-8674(00)80064-1 pmid:10520996
|
165 |
Homayouni R, Rice D S, Sheldon M, Curran T (1999). Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci , 19(17): 7507–7515 pmid:10460257
|
166 |
Hsieh J C, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines M E, Rosenquist T, Holdener B C (2003). Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell , 112(3): 355–367 doi: 10.1016/S0092-8674(03)00045-X pmid:12581525
|
167 |
Hu L, Boesten L S, May P, Herz J, Bovenschen N, Huisman M V, Berbée J F, Havekes L M, van Vlijmen B J, Tamsma J T (2006). Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice. Arterioscler Thromb Vasc Biol , 26(12): 2710–2715 doi: 10.1161/01.ATV.0000249641.96896.e6 pmid:17038633
|
168 |
Huang S S, Ling T Y, Tseng W F, Huang Y H, Tang F M, Leal S M, Huang J S (2003). Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. FASEB J , 17(14): 2068–2081 doi: 10.1096/fj.03-0256com pmid:14597676
|
169 |
Huovila A P, Turner A J, Pelto-Huikko M, K?rkk?inen I, Ortiz R M (2005). Shedding light on ADAM metalloproteinases. Trends Biochem Sci , 30(7): 413–422 doi: 10.1016/j.tibs.2005.05.006 pmid:15949939
|
170 |
Iijima H, Miyazawa M, Sakai J, Magoori K, Ito M R, Suzuki H, Nose M, Kawarabayasi Y, Yamamoto T T (1998). Expression and characterization of a very low density lipoprotein receptor variant lacking the O-linked sugar region generated by alternative splicing. J Biochem , 124(4): 747–755 pmid:9756619
|
171 |
Inestrosa N, De Ferrari G V, Garrido J L, Alvarez A, Olivares G H, Barría M I, Bronfman M, Chacón M A (2002). Wnt signaling involvement in beta-amyloid-dependent neurodegeneration. Neurochem Int , 41(5): 341–344 doi: 10.1016/S0197-0186(02)00056-6 pmid:12176076
|
172 |
Inestrosa N C, Varela-Nallar L, Grabowski C P, Colombres M (2007). Synaptotoxicity in Alzheimer’s disease: the Wnt signaling pathway as a molecular target. IUBMB Life , 59(4): 316–321 doi: 10.1080/15216540701242490 pmid:17505971
|
173 |
Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E (1998). A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. EMBO J , 17(24): 7260–7272 doi: 10.1093/emboj/17.24.7260 pmid:9857183
|
174 |
Jacobsen K T, Adlerz L, Multhaup G, Iverfeldt K (2010). Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases. J Biol Chem , 285(14): 10223–10231 doi: 10.1074/jbc.M109.038224 pmid:20139073
|
175 |
Jones C, Hammer R E, Li W P, Cohen J C, Hobbs H H, Herz J (2003). Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem , 278(31): 29024–29030 doi: 10.1074/jbc.M304855200 pmid:12746448
|
176 |
Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel C P, Glatzel M, De Strooper B, Saftig P (2010). The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. J Neurosci , 30(14): 4833–4844 doi: 10.1523/JNEUROSCI.5221-09.2010 pmid:20371803
|
177 |
Jung F F, Bachinsky D R, Tang S S, Zheng G, Diamant D, Haveran L, McCluskey R T, Ingelfinger J R (1998). Immortalized rat proximal tubule cells produce membrane bound and soluble megalin. Kidney Int , 53(2): 358–366 doi: 10.1046/j.1523-1755.1998.00766.x pmid:9461095
|
178 |
Jung H O, Uhm J S, Seo S M, Kim J H, Youn H J, Baek S H, Chung W S, Seung K B (2010). Angiotensin II-induced smooth muscle cell migration is mediated by LDL receptor-related protein 1 via regulation of matrix metalloproteinase 2 expression. Biochem Biophys Res Commun , 402(4): 577–582 doi: 10.1016/j.bbrc.2010.10.019 pmid:20940000
|
179 |
Kajita M, Itoh Y, Chiba T, Mori H, Okada A, Kinoh H, Seiki M (2001). Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol , 153(5): 893–904 doi: 10.1083/jcb.153.5.893 pmid:11381077
|
180 |
Kalani M Y, Cheshier S H, Cord B J, Bababeygy S R, Vogel H, Weissman I L, Palmer T D, Nusse R (2008). Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci USA , 105(44): 16970–16975 doi: 10.1073/pnas.0808616105 pmid:18957545
|
181 |
Kanning K C, Hudson M, Amieux P S, Wiley J C, Bothwell M, Schecterson L C (2003). Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci , 23(13): 5425–5436 pmid:12843241
|
182 |
Karsdal M A, Larsen L, Engsig M T, Lou H, Ferreras M, Lochter A, Delaissé J M, Foged N T (2002). Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. J Biol Chem , 277(46): 44061–44067 doi: 10.1074/jbc.M207205200 pmid:12226090
|
183 |
Kasza A, Petersen H H, Heegaard C W, Oka K, Christensen A, Dubin A, Chan L, Andreasen P A (1997). Specificity of serine proteinase/serpin complex binding to very-low-density lipoprotein receptor and alpha2-macroglobulin receptor/low-density-lipoprotein-receptor-related protein. Eur J Biochem , 248(2): 270–281 doi: 10.1111/j.1432-1033.1997.00270.x pmid:9346278
|
184 |
Keller R (2002). Shaping the vertebrate body plan by polarized embryonic cell movements. Science , 298(5600): 1950–1954 doi: 10.1126/science.1079478 pmid:12471247
|
185 |
Keshvara L, Benhayon D, Magdaleno S, Curran T (2001). Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. J Biol Chem , 276(19): 16008–16014 doi: 10.1074/jbc.M101422200 pmid:11279201
|
186 |
Killock D J, Iveti? A (2010). The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding. Biochem J , 428(2): 293–304 doi: 10.1042/BJ20091611 pmid:20331435
|
187 |
Kim D H, Iijima H, Goto K, Sakai J, Ishii H, Kim H J, Suzuki H, Kondo H, Saeki S, Yamamoto T (1996). Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J Biol Chem , 271(14): 8373–8380 pmid:8626535
|
188 |
Kim H S, Kim E M, Lee J P, Park C H, Kim S, Seo J H, Chang K A, Yu E, Jeong S J, Chong Y H, Suh Y H (2003). C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression. FASEB J , 17(13): 1951–1953 pmid:12923068
|
189 |
Klassen R B, Crenshaw K, Kozyraki R, Verroust P J, Tio L, Atrian S, Allen P L, Hammond T G (2004). Megalin mediates renal uptake of heavy metal metallothionein complexes. Am J Physiol Renal Physiol , 287(3): F393–F403 doi: 10.1152/ajprenal.00233.2003 pmid:15126248
|
190 |
Knauer M F, Kridel S J, Hawley S B, Knauer D J (1997). The efficient catabolism of thrombin-protease nexin 1 complexes is a synergistic mechanism that requires both the LDL receptor-related protein and cell surface heparins. J Biol Chem , 272(46): 29039–29045 doi: 10.1074/jbc.272.46.29039 pmid:9360977
|
191 |
Knauer M F, Orlando R A, Glabe C G (1996). Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res , 740(1-2): 6–14 doi: 10.1016/S0006-8993(96)00711-1 pmid:8973792
|
192 |
Knisely J M, Li Y, Griffith J M, Geuze H J, Schwartz A L, Bu G (2007). Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation. Exp Cell Res , 313(15): 3298–3307 doi: 10.1016/j.yexcr.2007.05.026 pmid:17658514
|
193 |
Koch S, Strasser V, Hauser C, Fasching D, Brandes C, Bajari T M, Schneider W J, Nimpf J (2002). A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling. EMBO J , 21(22): 5996–6004 doi: 10.1093/emboj/cdf599 pmid:12426372
|
194 |
Kojro E, Gimpl G, Lammich S, Marz W, Fahrenholz F (2001). Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha-secretase ADAM 10. Proc Natl Acad Sci USA , 98(10): 5815–5820 doi: 10.1073/pnas.081612998 pmid:11309494
|
195 |
K?nig O, Rüttiger L, Müller M, Zimmermann U, Erdmann B, Kalbacher H, Gross M, Knipper M (2007). Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss. FASEB J , 22(2): 410–417 doi: 10.1096/fj.07-9171com pmid:17846082
|
196 |
Kounnas M Z, Church F C, Argraves W S, Strickland D K (1996). Cellular internalization and degradation of antithrombin III-thrombin, heparin cofactor II-thrombin, and alpha 1-antitrypsin-trypsin complexes is mediated by the low density lipoprotein receptor-related protein. J Biol Chem , 271(11): 6523–6529 doi: 10.1074/jbc.271.11.6523 pmid:8626456
|
197 |
Kounnas M Z, Henkin J, Argraves W S, Strickland D K (1993). Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase. J Biol Chem , 268(29): 21862–21867 pmid:7691818
|
198 |
Kounnas M Z, Moir R D, Rebeck G W, Bush A I, Argraves W S, Tanzi R E, Hyman B T, Strickland D K (1995). LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell , 82(2): 331–340 doi: 10.1016/0092-8674(95)90320-8 pmid:7543026
|
199 |
Kristensen T, Moestrup S K, Gliemann J, Bendtsen L, Sand O, Sottrup-Jensen L (1990). Evidence that the newly cloned low-density-lipoprotein receptor related protein (LRP) is the alpha 2-macroglobulin receptor. FEBS Lett , 276(1-2): 151–155 doi: 10.1016/0014-5793(90)80530-V pmid:1702392
|
200 |
Kühl M, Sheldahl L C, Park M, Miller J R, Moon R T (2000). The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape. Trends Genet , 16(7): 279–283 pmid:10858654
|
201 |
Kuhn P H, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart J W, Kremmer E, Rossner S, Lichtenthaler S F (2010). ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons. EMBO J , 29(17): 3020–3032 doi: 10.1038/emboj.2010.167 pmid:20676056
|
202 |
Kuro-o M (2008). Endocrine FGFs and Klothos: emerging concepts. Trends Endocrinol Metab , 19(7): 239–245 doi: 10.1016/j.tem.2008.06.002 pmid:18692401
|
203 |
Kwon O Y, Hwang K, Kim J A, Kim K, Kwon I C, Song H K, Jeon H (2010). Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing. J Cell Biochem , 111(2): 508–519 doi: 10.1002/jcb.22738 pmid:20568118
|
204 |
Lanske B, Razzaque M S (2007). Vitamin D and aging: old concepts and new insights. J Nutr Biochem , 18(12): 771–777 doi: 10.1016/j.jnutbio.2007.02.002 pmid:17531460
|
205 |
Larsson M, Hj?lm G, Sakwe A M, Engstr?m A, H?glund A S, Larsson E, Robinson R C, Sundberg C, Rask L (2003). Selective interaction of megalin with postsynaptic density-95 (PSD-95)-like membrane-associated guanylate kinase (MAGUK) proteins. Biochem J , 373(2): 381–391 doi: 10.1042/BJ20021958 pmid:12713445
|
206 |
Leheste J R, Melsen F, Wellner M, Jansen P, Schlichting U, Renner-Müller I, Andreassen T T, Wolf E, Bachmann S, Nykjaer A, Willnow T E (2003). Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. FASEB J , 17(2): 247–249 pmid:12475886
|
207 |
Leheste J R, Rolinski B, Vorum H, Hilpert J, Nykjaer A, Jacobsen C, Aucouturier P, Moskaug J O, Otto A, Christensen E I, Willnow T E (1999). Megalin knockout mice as an animal model of low molecular weight proteinuria. Am J Pathol , 155(4): 1361–1370 doi: 10.1016/S0002-9440(10)65238-8 pmid:10514418
|
208 |
Lehti K, Rose N F, Valavaara S, Weiss S J, Keski-Oja J (2009). MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing. J Cell Sci , 122(1): 126–135 doi: 10.1242/jcs.035279 pmid:19066283
|
209 |
Lemjabbar-Alaoui H, Sidhu S S, Mengistab A, Gallup M, Basbaum C (2011). TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS ONE , 6(3): e17489 doi: 10.1371/journal.pone.0017489 pmid:21423656
|
210 |
Lenting P J, Neels J G, van den Berg B M, Clijsters P P, Meijerman D W, Pannekoek H, van Mourik J A, Mertens K, van Zonneveld A J (1999). The light chain of factor VIII comprises a binding site for low density lipoprotein receptor-related protein. J Biol Chem , 274(34): 23734–23739 doi: 10.1074/jbc.274.34.23734 pmid:10446132
|
211 |
Li Y, Bu G (2005). LRP5/6 in Wnt signaling and tumorigenesis. Future Oncol , 1(5): 673–681 doi: 10.2217/14796694.1.5.673 pmid:16556044
|
212 |
Li Y, Cong R, Biemesderfer D (2008). The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells. Am J Physiol Cell Physiol , 295(2): C529–C537 doi: 10.1152/ajpcell.00037.2008 pmid:18495814
|
213 |
Li Y, Knisely J M, Lu W, McCormick L M, Wang J, Henkin J, Schwartz A L, Bu G (2002). Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. J Biol Chem , 277(44): 42366–42371 doi: 10.1074/jbc.M207705200 pmid:12194987
|
214 |
Li Y, Lu W, Bu G (2005). Striking differences of LDL receptor-related protein 1B expression in mouse and human. Biochem Biophys Res Commun , 333(3): 868–873 doi: 10.1016/j.bbrc.2005.05.170 pmid:15963947
|
215 |
Li Y, Marzolo M P, van Kerkhof P, Strous G J, Bu G (2000). The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. J Biol Chem , 275(22): 17187–17194 doi: 10.1074/jbc.M000490200 pmid:10747918
|
216 |
Li Y, Wood N, Donnelly P, Yellowlees D (1998a). Cell density and oestrogen both stimulate alpha 2-macroglobulin receptor expression in breast cancer cell T-47D. Anticancer Res , 18(2A): 1197–1202 pmid:9615788
|
217 |
Li Y, Wood N, Grimsley P, Yellowlees D, Donnelly P K (1998b). In vitro invasiveness of human breast cancer cells is promoted by low density lipoprotein receptor-related protein. Invasion Metastasis , 18(5-6): 240–251 doi: 10.1159/000024517 pmid:10729769
|
218 |
Li Y, Wood N, Yellowlees D, Donnelly P (1997). Expression of alpha 2 macroglobulin receptor/low density lipoprotein receptor-related protein is cell culture density-dependent in human breast cancer cell line BT-20. Biochem Biophys Res Commun , 240(1): 122–127 doi: 10.1006/bbrc.1997.7619 pmid:9367895
|
219 |
Lichtenthaler S F, Haass C, Steiner H (2011). Regulated intramembrane proteolysis—lessons from amyloid precursor protein processing. J Neurochem , 117(5): 779–796 doi: 10.1111/j.1471-4159.2011.07248.x pmid:21413990
|
220 |
Lighthouse J K, Zhang L, Hsieh J C, Rosenquist T, Holdener B C (2010). MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn: Lillis A P, Van Duyn L B, Murphy-Ullrich J E, Strickland D K (2008). LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. Physiol Rev , 88(3): 887–918 doi: 10.1029/2008GL034338.
|
221 |
Lillis K P, Enga A, White J A, Mertz J (2008). Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution. Journal of Neuroscience Methods , 172: 178–184
|
222 |
Lin D C, Quevedo C, Brewer N E, Bell A, Testa J R, Grimes M L, Miller F D, Kaplan D R (2006). APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. Mol Cell Biol , 26(23): 8928–8941 doi: 10.1128/MCB.00228-06 pmid:17000777
|
223 |
Liu C X, Li Y, Obermoeller-McCormick L M, Schwartz A L, Bu G (2001). The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. J Biol Chem , 276(31): 28889–28896 doi: 10.1074/jbc.M102727200 pmid:11384978
|
224 |
Liu C X, Musco S, Lisitsina N M, Yaklichkin S Y, Lisitsyn N A (2000). Genomic organization of a new candidate tumor suppressor gene, LRP1B. Genomics , 69(2): 271–274 doi: 10.1006/geno.2000.6331 pmid:11031110
|
225 |
Liu C X, Ranganathan S, Robinson S, Strickland D K (2006). gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells. J Biol Chem , 282(10): 7504–7511 doi: 10.1074/jbc.M608088200 pmid:17227771
|
226 |
Liu Q, Zhang J, Tran H, Verbeek M M, Reiss K, Estus S, Bu G (2009). LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Mol Neurodegener , 4(1): 17 doi: 10.1186/1750-1326-4-17 pmid:19371428
|
227 |
Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah N G, Isra?l A (1998). The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA , 95(14): 8108–8112 doi: 10.1073/pnas.95.14.8108 pmid:9653148
|
228 |
Lou X, McQuistan T, Orlando R A, Farquhar M G (2002). GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin’s function. J Am Soc Nephrol , 13(4): 918–927 pmid:11912251
|
229 |
Loukinova E, Ranganathan S, Kuznetsov S, Gorlatova N, Migliorini M M, Loukinov D, Ulery P G, Mikhailenko I, Lawrence D A, Strickland D K (2002). Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. J Biol Chem , 277(18): 15499–15506 doi: 10.1074/jbc.M200427200 pmid:11854294
|
230 |
Lu W, Yamamoto V, Ortega B, Baltimore D (2004). Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell , 119(1): 97–108 doi: 10.1016/j.cell.2004.09.019 pmid:15454084
|
231 |
Lu Y J, Wu C S, Li H P, Liu H P, Lu C Y, Leu Y W, Wang C S, Chen L C, Lin K H, Chang Y S (2010). Aberrant methylation impairs low density lipoprotein receptor-related protein 1B tumor suppressor function in gastric cancer. Genes Chromosomes Cancer , 49(5): 412–424 pmid:20095042
|
232 |
Lundgren S, Carling T, Hj?lm G, Juhlin C, Rastad J, Pihlgren U, Rask L, Akerstr?m G, Hellman P (1997). Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein. J Histochem Cytochem , 45(3): 383–392 doi: 10.1177/002215549704500306 pmid:9071320
|
233 |
MacDonald B T, Semenov M V, Huang H, He X (2011). Dissecting Molecular Differences between Wnt Coreceptors LRP5 and LRP6. PLoS ONE , 6(8): e23537 doi: 10.1371/journal.pone.0023537 pmid:21887268
|
234 |
Magrané J, Casaroli-Marano R P, Reina M, G?fvels M, Vilaró S (1999). The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS Lett , 451(1): 56–62 doi: 10.1016/S0014-5793(99)00494-9 pmid:10356983
|
235 |
Mantuano E, Inoue G, Li X, Takahashi K, Gaultier A, Gonias S L, Campana W M (2008). The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci , 28(45): 11571–11582 doi: 10.1523/JNEUROSCI.3053-08.2008 pmid:18987193
|
236 |
Mao J, Wang J, Liu B, Pan W, Farr G H 3rd, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D (2001). Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell , 7(4): 801–809 doi: 10.1016/S1097-2765(01)00224-6 pmid:11336703
|
237 |
Mao X, Kikani C K, Riojas R A, Langlais P, Wang L, Ramos F J, Fang Q, Christ-Roberts C Y, Hong J Y, Kim R Y, Liu F, Dong L Q (2006). APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol , 8(5): 516–523 doi: 10.1038/ncb1404 pmid:16622416
|
238 |
Marcello E, Gardoni F, Mauceri D, Romorini S, Jeromin A, Epis R, Borroni B, Cattabeni F, Sala C, Padovani A, Di Luca M (2007). Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. J Neurosci , 27(7): 1682–1691 doi: 10.1523/JNEUROSCI.3439-06.2007 pmid:17301176
|
239 |
Marinò M, Zheng G, McCluskey R T (1999). Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured fisher rat thyroid cells. J Biol Chem , 274(18): 12898–12904 doi: 10.1074/jbc.274.18.12898 pmid:10212279
|
240 |
Marschang P, Brich J, Weeber E J, Sweatt J D, Shelton J M, Richardson J A, Hammer R E, Herz J (2004). Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Mol Cell Biol , 24(9): 3782–3793 doi: 10.1128/MCB.24.9.3782-3793.2004 pmid:15082773
|
241 |
Martensen P M, Oka K, Christensen L, Rettenberger P M, Petersen H H, Christensen A, Chan L, Heegaard C W, Andreasen P A (1997). Breast carcinoma epithelial cells express a very low-density lipoprotein receptor variant lacking the O-linked glycosylation domain encoded by exon 16, but with full binding activity for serine proteinase/serpin complexes and Mr-40,000 receptor-associated protein. Eur J Biochem , 248(2): 583–591 doi: 10.1111/j.1432-1033.1997.00583.x pmid:9346319
|
242 |
Martin A M, Kuhlmann C, Trossbach S, Jaeger S, Waldron E, Roebroek A, Luhmann H J, Laatsch A, Weggen S, Lessmann V, Pietrzik C U (2008). The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors. J Biol Chem , 283(18): 12004–12013 doi: 10.1074/jbc.M707607200 pmid:18321860
|
243 |
Marzolo M P, Bu G (2009). Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer’s disease. Semin Cell Dev Biol , 20(2): 191–200 doi: 10.1016/j.semcdb.2008.10.005 pmid:19041409
|
244 |
Marzolo M P, Farfán P (2011). New insights into the roles of megalin/LRP2 and the regulation of its functional expression. Biol Res , 44(1): 89–105 doi: 10.4067/S0716-97602011000100012 pmid:21720686
|
245 |
Marzolo M P, Yuseff M I, Retamal C, Donoso M, Ezquer F, Farfán P, Li Y, Bu G (2003). Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains. Traffic , 4(4): 273–288 doi: 10.1034/j.1600-0854.2003.00081.x pmid:12694565
|
246 |
Massova I, Kotra L P, Fridman R, Mobashery S (1998). Matrix metalloproteinases: structures, evolution, and diversification. FASEB J , 12(12): 1075–1095 pmid:9737711
|
247 |
Matsuno H, Yudoh K, Watanabe Y, Nakazawa F, Aono H, Kimura T (2001). Stromelysin-1 (MMP-3) in synovial fluid of patients with rheumatoid arthritis has potential to cleave membrane bound Fas ligand. J Rheumatol , 28(1): 22–28 pmid:11196534
|
248 |
Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen K J, Rose-John S (2003). Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem , 278(40): 38829–38839 doi: 10.1074/jbc.M210584200 pmid:12832423
|
249 |
May P, Bock H H, Herz J (2003a). Integration of endocytosis and signal transduction by lipoprotein receptors. Sci STKE , 2003(176): 12pe doi: 10.1126/stke.2003.176.pe12 pmid:12671190
|
250 |
May P, Bock H H, Nimpf J, Herz J (2003b). Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J Biol Chem , 278(39): 37386–37392 doi: 10.1074/jbc.M305858200 pmid:12871934
|
251 |
May P, Reddy Y K, Herz J (2002). Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem , 277(21): 18736–18743 doi: 10.1074/jbc.M201979200 pmid:11907044
|
252 |
May P, Rohlmann A, Bock H H, Zurhove K, Marth J D, Schomburg E D, Noebels J L, Beffert U, Sweatt J D, Weeber E J, Herz J (2004). Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol , 24(20): 8872–8883 doi: 10.1128/MCB.24.20.8872-8883.2004 pmid:15456862
|
253 |
McCarthy R A, Barth J L, Chintalapudi M R, Knaak C, Argraves W S (2002). Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem , 277(28): 25660–25667 doi: 10.1074/jbc.M201933200 pmid:11964399
|
254 |
McKendry R, Hsu S C, Harland R M, Grosschedl R (1997). LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Dev Biol , 192(2): 420–431 doi: 10.1006/dbio.1997.8797 pmid:9441678
|
255 |
McLoughlin D M, Miller C C (2008). The FE65 proteins and Alzheimer’s disease. J Neurosci Res , 86(4): 744–754 doi: 10.1002/jnr.21532 pmid:17828772
|
256 |
Merlos-Suárez A, Ruiz-Paz S, Baselga J, Arribas J (2001). Metalloprotease-dependent protransforming growth factor-alpha ectodomain shedding in the absence of tumor necrosis factor-alpha-converting enzyme. J Biol Chem , 276(51): 48510–48517 pmid:11600492
|
257 |
Mi K, Dolan P J, Johnson G V (2005). The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity. J Biol Chem , 281(8): 4787–4794 doi: 10.1074/jbc.M508657200 pmid:16365045
|
258 |
Mi K, Johnson G V (2005). Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway. J Cell Biochem , 95(2): 328–338 doi: 10.1002/jcb.20400 pmid:15778991
|
259 |
Mi K, Johnson G V (2007). Regulated proteolytic processing of LRP6 results in release of its intracellular domain. J Neurochem , 101(2): 517–529 doi: 10.1111/j.1471-4159.2007.04447.x pmid:17326769
|
260 |
Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton R G, Zerial M (2004). APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell , 116(3): 445–456 doi: 10.1016/S0092-8674(04)00117-5 pmid:15016378
|
261 |
Miller J R, Hocking A M, Brown J D, Moon R T (1999). Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways. Oncogene , 18(55): 7860–7872 doi: 10.1038/sj.onc.1203245 pmid:10630639
|
262 |
Miller S I, Ernst R K, Bader M W (2005). LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol , 3(1): 36–46 doi: 10.1038/nrmicro1068 pmid:15608698
|
263 |
Minami Y, Oishi I, Endo M, Nishita M (2010). Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev Dyn , 239(1): 1–15 pmid:19530173
|
264 |
Mizuta K, Saito A, Watanabe T, Nagura M, Arakawa M, Shimizu F, Hoshino T (1999). Ultrastructural localization of megalin in the rat cochlear duct. Hear Res , 129(1-2): 83–91 doi: 10.1016/S0378-5955(98)00221-4 pmid:10190754
|
265 |
Moestrup S K, Gliemann J (1989). Purification of the rat hepatic alpha 2-macroglobulin receptor as an approximately 440-kDa single chain protein. J Biol Chem , 264(26): 15574–15577 pmid:2475504
|
266 |
Moestrup S K, Kozyraki R, Kristiansen M, Kaysen J H, Rasmussen H H, Brault D, Pontillon F, Goda F O, Christensen E I, Hammond T G, Verroust P J (1998). The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins. J Biol Chem , 273(9): 5235–5242 doi: 10.1074/jbc.273.9.5235 pmid:9478979
|
267 |
Moestrup S K, Verroust P J (2001). Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia. Annu Rev Nutr , 21(1): 407–428 doi: 10.1146/annurev.nutr.21.1.407 pmid:11375443
|
268 |
Montcouquiol M, Rachel R A, Lanford P J, Copeland N G, Jenkins N A, Kelley M W (2003). Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature , 423(6936): 173–177 doi: 10.1038/nature01618 pmid:12724779
|
269 |
Morales C R, Igdoura S A, Wosu U A, Boman J, Argraves W S (1996). Low density lipoprotein receptor-related protein-2 expression in efferent duct and epididymal epithelia: evidence in rats for its In vivo role in endocytosis of apolipoprotein J/clusterin. Biol Reprod , 55(3): 676–683 doi: 10.1095/biolreprod55.3.676 pmid:8862787
|
270 |
Morris S M, Arden S D, Roberts R C, Kendrick-Jones J, Cooper J A, Luzio J P, Buss F (2002a). Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. Traffic , 3(5): 331–341 doi: 10.1034/j.1600-0854.2002.30503.x pmid:11967127
|
271 |
Morris S M, Cooper J A (2001). Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic , 2(2): 111–123 doi: 10.1034/j.1600-0854.2001.020206.x pmid:11247302
|
272 |
Morris S M, Tallquist M D, Rock C O, Cooper J A (2002b). Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J , 21(7): 1555–1564 doi: 10.1093/emboj/21.7.1555 pmid:11927540
|
273 |
Mu D, Cambier S, Fjellbirkeland L, Baron J L, Munger J S, Kawakatsu H, Sheppard D, Broaddus V C, Nishimura S L (2002). The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol , 157(3): 493–507 doi: 10.1083/jcb.200109100 pmid:11970960
|
274 |
M?ller T, Concannon C G, Ward M W, Walsh C M, Tirniceriu A L, Tribl F, K?gel D, Prehn J H, Egensperger R (2006). Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD). Mol Biol Cell , 18(1): 201–210 doi: 10.1091/mbc.E06-04-0283 pmid:17093061
|
275 |
Murphy G (2009). Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’. Semin Cell Dev Biol , 20(2): 138–145 doi: 10.1016/j.semcdb.2008.09.004 pmid:18840536
|
276 |
Murphy-Ullrich J E, H??k M (1989). Thrombospondin modulates focal adhesions in endothelial cells. J Cell Biol , 109(3): 1309–1319 doi: 10.1083/jcb.109.3.1309 pmid:2768342
|
277 |
Myers D C, Sepich D S, Solnica-Krezel L (2002). Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity? Trends Genet , 18(9): 447–455 doi: 10.1016/S0168-9525(02)02725-7 pmid:12175805
|
278 |
Naccache S N, Hasson T, Horowitz A (2006). Binding of internalized receptors to the PDZ domain of GIPC/synectin recruits myosin VI to endocytic vesicles. Proc Natl Acad Sci USA , 103(34): 12735–12740 doi: 10.1073/pnas.0605317103 pmid:16908842
|
279 |
Nagai M, Meerloo T, Takeda T, Farquhar M G (2003). The adaptor protein ARH escorts megalin to and through endosomes. Mol Biol Cell , 14(12): 4984–4996 doi: 10.1091/mbc.E03-06-0385 pmid:14528014
|
280 |
Nakagawa T, Pimkhaokham A, Suzuki E, Omura K, Inazawa J, Imoto I (2006). Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma. Cancer Sci , 97(10): 1070–1074 doi: 10.1111/j.1349-7006.2006.00283.x pmid:16918994
|
281 |
Nakamura Y, Yamamoto M, Kumamaru E (1998). A variant very low density lipoprotein receptor lacking 84 base pairs of O-linked sugar domain in the human brain myelin. Brain Res , 793(1-2): 47–53 doi: 10.1016/S0006-8993(98)00112-7 pmid:9630508
|
282 |
Neels J G, van Den Berg B M, Lookene A, Olivecrona G, Pannekoek H, van Zonneveld A J (1999). The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. J Biol Chem , 274(44): 31305–31311 (In Process Citation) doi: 10.1074/jbc.274.44.31305 pmid:10531329
|
283 |
Nielsen R, Birn H, Moestrup S K, Nielsen M, Verroust P, Christensen E I (1998). Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin. J Am Soc Nephrol , 9(10): 1767–1776 pmid:9773777
|
284 |
Nielsen R, Courtoy P J, Jacobsen C, Dom G, Lima W R, Jadot M, Willnow T E, Devuyst O, Christensen E I (2007). Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cells. Proc Natl Acad Sci USA , 104(13): 5407–5412 doi: 10.1073/pnas.0700330104 pmid:17369355
|
285 |
Nishitsuji K, Hosono T, Nakamura T, Bu G, Michikawa M (2011). Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an In vitro blood-brain barrier model. J Biol Chem , 286(20): 17536–17542 doi: 10.1074/jbc.M111.225532 pmid:21471207
|
286 |
Niu X, Shi H, Peng J (2010). The role of mesodermal signals during liver organogenesis in zebrafish. Sci China Life Sci , 53(4): 455–461 doi: 10.1007/s11427-010-0078-4 pmid:20596911
|
287 |
Norden A G, Lapsley M, Igarashi T, Kelleher C L, Lee P J, Matsuyama T, Scheinman S J, Shiraga H, Sundin D P, Thakker R V, Unwin R J, Verroust P, Moestrup S K (2002). Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome. J Am Soc Nephrol , 13(1): 125–133 pmid:11752029
|
288 |
Novak S, Hiesberger T, Schneider W J, Nimpf J (1996). A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse. J Biol Chem , 271(20): 11732–11736 doi: 10.1074/jbc.271.20.11732 pmid:8662771
|
289 |
Nykjaer A, Dragun D, Walther D, Vorum H, Jacobsen C, Herz J, Melsen F, Christensen E I, Willnow T E (1999). An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell , 96(4): 507–515 doi: 10.1016/S0092-8674(00)80655-8 pmid:10052453
|
290 |
Nykjaer A, Petersen C M, M?ller B, Jensen P H, Moestrup S K, Holtet T L, Etzerodt M, Th?gersen H C, Munch M, Andreasen P A (1992). Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J Biol Chem , 267(21): 14543–14546 pmid:1378833
|
291 |
Ogawa M (2000). Corticohistogenesis and Reelin signal cascade. Nihon Shinkei Seishin Yakurigaku Zasshi , 20(4): 169–174 pmid:11215402
|
292 |
Ogawa M, Miyata T, Nakajima K, Yagyu K, Seike M, Ikenaka K, Yamamoto H, Mikoshiba K (1995). The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Neuron , 14(5): 899–912 doi: 10.1016/0896-6273(95)90329-1 pmid:7748558
|
293 |
Ogden C A, deCathelineau A, Hoffmann P R, Bratton D, Ghebrehiwet B, Fadok V A, Henson P M (2001). C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med , 194(6): 781–796 doi: 10.1084/jem.194.6.781 pmid:11560994
|
294 |
Ohuchi E, Imai K, Fujii Y, Sato H, Seiki M, Okada Y (1997). Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem , 272(4): 2446–2451 doi: 10.1074/jbc.272.4.2446 pmid:8999957
|
295 |
Oka K, Ishimura-Oka K, Chu M J, Sullivan M, Krushkal J, Li W H, Chan L (1994). Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. Eur J Biochem , 224(3): 975–982 doi: 10.1111/j.1432-1033.1994.00975.x pmid:7925422
|
296 |
Okada S S, Grobmyer S R, Barnathan E S (1996). Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion. Arterioscler Thromb Vasc Biol , 16(10): 1269–1276 doi: 10.1161/01.ATV.16.10.1269 pmid:8857924
|
297 |
Oleinikov A V, Zhao J, Makker S P (2000). Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. Biochem J , 347(3): 613–621 doi: 10.1042/0264-6021:3470613 pmid:10769163
|
298 |
Orford K, Crockett C, Jensen J P, Weissman A M, Byers S W (1997). Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem , 272(40): 24735–24738 doi: 10.1074/jbc.272.40.24735 pmid:9312064
|
299 |
Orlando R A, Rader K, Authier F, Yamazaki H, Posner B I, Bergeron J J, Farquhar M G (1998). Megalin is an endocytic receptor for insulin. J Am Soc Nephrol , 9(10): 1759–1766 pmid:9773776
|
300 |
Orr A W, Elzie C A, Kucik D F, Murphy-Ullrich J E (2003). Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci , 116(14): 2917–2927 doi: 10.1242/jcs.00600 pmid:12808019
|
301 |
Orr A W, Pallero M A, Murphy-Ullrich J E (2002). Thrombospondin stimulates focal adhesion disassembly through Gi- and phosphoinositide 3-kinase-dependent ERK activation. J Biol Chem , 277(23): 20453–20460 doi: 10.1074/jbc.M112091200 pmid:11923291
|
302 |
Osono Y, Woollett L A, Herz J, Dietschy J M (1995). Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse. J Clin Invest , 95(3): 1124–1132 doi: 10.1172/JCI117760 pmid:7883961
|
303 |
Overton C D, Yancey P G, Major A S, Linton M F, Fazio S (2007). Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse. Circ Res , 100(5): 670–677 doi: 10.1161/01.RES.0000260204.40510.aa pmid:17303763
|
304 |
Parr B A, McMahon A P (1994). Wnt genes and vertebrate development. Curr Opin Genet Dev , 4(4): 523–528 doi: 10.1016/0959-437X(94)90067-D pmid:7950319
|
305 |
Patrie K M, Drescher A J, Goyal M, Wiggins R C, Margolis B (2001). The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. J Am Soc Nephrol , 12(4): 667–677 pmid:11274227
|
306 |
Pedersen M O, Hansen P B, Nielsen S L, Penkowa M (2010). Metallothionein-I + II and receptor megalin are altered in relation to oxidative stress in cerebral lymphomas. Leuk Lymphoma , 51(2): 314–328 doi: 10.3109/10428190903518329 pmid:20038220
|
307 |
Peiretti F, Deprez-Beauclair P, Bonardo B, Aubert H, Juhan-Vague I, Nalbone G (2003). Identification of SAP97 as an intracellular binding partner of TACE. J Cell Sci , 116(10): 1949–1957 doi: 10.1242/jcs.00415 pmid:12668732
|
308 |
Petersen H H, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek A J, Willnow T E (2003). Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. J Cell Sci , 116(3): 453–461 doi: 10.1242/jcs.00243 pmid:12508107
|
309 |
Piao S, Lee S H, Kim H, Yum S, Stamos J L, Xu Y, Lee S J, Lee J, Oh S, Han J K, Park B J, Weis W I, Ha N C (2008). Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling. PLoS ONE , 3(12): e4046 doi: 10.1371/journal.pone.0004046 pmid:19107203
|
310 |
Pietrzik C U, Busse T, Merriam D E, Weggen S, Koo E H (2002). The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J , 21(21): 5691–5700 doi: 10.1093/emboj/cdf568 pmid:12411487
|
311 |
Pietrzik C U, Yoon I S, Jaeger S, Busse T, Weggen S, Koo E H (2004). FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci , 24(17): 4259–4265 doi: 10.1523/JNEUROSCI.5451-03.2004 pmid:15115822
|
312 |
Pilecka I, Banach-Orlowska M, Miaczynska M (2007). Nuclear functions of endocytic proteins. Eur J Cell Biol , 86(9): 533–547 doi: 10.1016/j.ejcb.2007.04.004 pmid:17583371
|
313 |
Pinson K I, Brennan J, Monkley S, Avery B J, Skarnes W C (2000). An LDL-receptor-related protein mediates Wnt signalling in mice. Nature , 407(6803): 535–538 (In Process Citation) doi: 10.1038/35035124 pmid:11029008
|
314 |
Polavarapu R, An J, Zhang C, Yepes M (2008). Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death. Am J Pathol , 172(5): 1355–1362 doi: 10.2353/ajpath.2008.070975 pmid:18403601
|
315 |
Polavarapu R, Gongora M C, Yi H, Ranganthan S, Lawrence D A, Strickland D, Yepes M (2007). Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit. Blood , 109(8): 3270–3278 doi: 10.1182/blood-2006-08-043125 pmid:17170123
|
316 |
Pompili V J, Gordon D, San H, Yang Z, Muller D W, Nabel G J, Nabel E G (1995). Expression and function of a recombinant PDGF B gene in porcine arteries. Arterioscler Thromb Vasc Biol , 15(12): 2254–2264 doi: 10.1161/01.ATV.15.12.2254 pmid:7489251
|
317 |
Pujadas L, Gruart A, Bosch C, Delgado L, Teixeira C M, Rossi D, de Lecea L, Martínez A, Delgado-García J M, Soriano E (2010). Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. J Neurosci , 30(13): 4636–4649 doi: 10.1523/JNEUROSCI.5284-09.2010 pmid:20357114
|
318 |
Quinn K A, Grimsley P G, Dai Y P, Tapner M, Chesterman C N, Owensby D A (1997). Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma. J Biol Chem , 272(38): 23946–23951 doi: 10.1074/jbc.272.38.23946 pmid:9295345
|
319 |
Quinn K A, Pye V J, Dai Y P, Chesterman C N, Owensby D A (1999). Characterization of the soluble form of the low density lipoprotein receptor-related protein (LRP). Exp Cell Res , 251(2): 433–441 doi: 10.1006/excr.1999.4590 pmid:10471328
|
320 |
Rader K, Orlando R A, Lou X, Farquhar M G (2000). Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. J Am Soc Nephrol , 11(12): 2167–2178 pmid:11095640
|
321 |
Reiss K, Ludwig A, Saftig P (2006). Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion. Pharmacol Ther , 111(3): 985–1006 doi: 10.1016/j.pharmthera.2006.02.009 pmid:16626807
|
322 |
Rice D S, Sheldon M, D’Arcangelo G, Nakajima K, Goldowitz D, Curran T (1998). Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain. Development , 125(18): 3719–3729 pmid:9716537
|
323 |
Riddell D R, Sun X M, Stannard A K, Soutar A K, Owen J S (2001). Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J Lipid Res , 42(6): 998–1002 pmid:11369809
|
324 |
Riddell D R, Vinogradov D V, Stannard A K, Chadwick N, Owen J S (1999). Identification and characterization of LRP8 (apoER2) in human blood platelets. J Lipid Res , 40(10): 1925–1930 pmid:10508213
|
325 |
Rohlmann A, Gotthardt M, Hammer R E, Herz J (1998). Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants. J Clin Invest , 101(3): 689–695 doi: 10.1172/JCI1240 pmid:9449704
|
326 |
Rowling M J, Kemmis C M, Taffany D A, Welsh J (2006). Megalin-mediated endocytosis of vitamin D binding protein correlates with 25-hydroxycholecalciferol actions in human mammary cells. J Nutr , 136(11): 2754–2759 pmid:17056796
|
327 |
Rozanov D V, Hahn-Dantona E, Strickland D K, Strongin A Y (2003). The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells. J Biol Chem , 279(6): 4260–4268 doi: 10.1074/jbc.M311569200 pmid:14645246
|
328 |
Rubera I, Poujeol C, Bertin G, Hasseine L, Counillon L, Poujeol P, Tauc M (2004). Specific Cre/Lox recombination in the mouse proximal tubule. J Am Soc Nephrol , 15(8): 2050–2056 doi: 10.1097/01.ASN.0000133023.89251.01 pmid:15284291
|
329 |
Ruiz J, Kouiavskaia D, Migliorini M, Robinson S, Saenko E L, Gorlatova N, Li D, Lawrence D, Hyman B T, Weisgraber K H, Strickland D K (2005). The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res , 46(8): 1721–1731 doi: 10.1194/jlr.M500114-JLR200 pmid:15863833
|
330 |
Saenko E L, Yakhyaev A V, Mikhailenko I, Strickland D K, Sarafanov A G (1999). Role of the low density lipoprotein-related protein receptor in mediation of factor VIII catabolism. J Biol Chem , 274(53): 37685–37692 doi: 10.1074/jbc.274.53.37685 pmid:10608826
|
331 |
Saito A, Pietromonaco S, Loo A K, Farquhar M G (1994). Complete cloning and sequencing of rat gp330/”megalin,” a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA , 91(21): 9725–9729 doi: 10.1073/pnas.91.21.9725 pmid:7937880
|
332 |
Saitoh T, Mine T, Katoh M (2002). Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Int J Mol Med , 9(5): 515–519 pmid:11956659
|
333 |
Sakai K, Tiebel O, Ljungberg M C, Sullivan M, Lee H J, Terashima T, Li R, Kobayashi K, Lu H C, Chan L, Oka K (2009). A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. Brain Res , 1276: 11–21 doi: 10.1016/j.brainres.2009.04.030 pmid:19393635
|
334 |
Salicioni A M, Gaultier A, Brownlee C, Cheezum M K, Gonias S L (2003). Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. J Biol Chem , 279(11): 10005–10012 doi: 10.1074/jbc.M306625200 pmid:14699139
|
335 |
Schl?ndorff J, Lum L, Blobel C P (2001). Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem , 276(18): 14665–14674 doi: 10.1074/jbc.M010741200 pmid:11278735
|
336 |
Seiki M (2003). Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer Lett , 194(1): 1–11 doi: 10.1016/S0304-3835(02)00699-7 pmid:12706853
|
337 |
Seki N, Bujo H, Jiang M, Tanaga K, Takahashi K, Yagui K, Hashimoto N, Schneider W J, Saito Y (2005). LRP1B is a negative modulator of increased migration activity of intimal smooth muscle cells from rabbit aortic plaques. Biochem Biophys Res Commun , 331(4): 964–970 doi: 10.1016/j.bbrc.2005.04.021 pmid:15882972
|
338 |
Selvais C, D’Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, Dedieu S, No?l A, Nagase H, Henriet P, Courtoy P J, Marbaix E, Emonard H (2011). Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function. FASEB J , 25(8): 2770–2781 doi: 10.1096/fj.10-169508 pmid:21518850
|
339 |
Selvais C, Gaide Chevronnay H P, Lemoine P, Dedieu S, Henriet P, Courtoy P J, Marbaix E, Emonard H (2009). Metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinase-2 and -9 at menstruation. Endocrinology , 150(8): 3792–3799 doi: 10.1210/en.2009-0015 pmid:19406945
|
340 |
Sentürk A, Pfennig S, Weiss A, Burk K, Acker-Palmer A (2011). Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration. Nature , 472(7343): 356–360 doi: 10.1038/nature09874 pmid:21460838
|
341 |
Shirakabe K, Wakatsuki S, Kurisaki T, Fujisawa-Sehara A (2001). Roles of Meltrin beta /ADAM19 in the processing of neuregulin. J Biol Chem , 276(12): 9352–9358 doi: 10.1074/jbc.M007913200 pmid:11116142
|
342 |
Shiroshima T, Oka C, Kawaichi M (2009). Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1. FEBS Lett , 583(1): 43–48 doi: 10.1016/j.febslet.2008.11.045 pmid:19071120
|
343 |
Simó S, Pujadas L, Segura M F, La Torre A, Del Río J A, Ure?a J M, Comella J X, Soriano E (2006). Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation. Cereb Cortex , 17(2): 294–303 doi: 10.1093/cercor/bhj147 pmid:16514107
|
344 |
Skovronsky D M, Moore D B, Milla M E, Doms R W, Lee V M (2000). Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem , 275(4): 2568–2575 doi: 10.1074/jbc.275.4.2568 pmid:10644715
|
345 |
Slusarski D C, Corces V G, Moon R T (1997). Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature , 390(6658): 410–413 doi: 10.1038/37138 pmid:9389482
|
346 |
Song H, Bu G (2009). MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1. Biochem Biophys Res Commun , 388(2): 400–405 doi: 10.1016/j.bbrc.2009.08.020 pmid:19665999
|
347 |
Song H, Li Y, Lee J, Schwartz A L, Bu G (2009). Low-density lipoprotein receptor-related protein 1 promotes cancer cell migration and invasion by inducing the expression of matrix metalloproteinases 2 and 9. Cancer Res , 69(3): 879–886 doi: 10.1158/0008-5472.CAN-08-3379 pmid:19176371
|
348 |
Soond S M, Everson B, Riches D W, Murphy G (2005). ERK-mediated phosphorylation of Thr735 in TNFalpha-converting enzyme and its potential role in TACE protein trafficking. J Cell Sci , 118(11): 2371–2380 doi: 10.1242/jcs.02357 pmid:15923650
|
349 |
Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen O M, Jerchow B, Willnow T E (2005). LRP2/megalin is required for patterning of the ventral telencephalon. Development , 132(2): 405–414 doi: 10.1242/dev.01580 pmid:15623804
|
350 |
Stefansson S, Lawrence D A, Argraves W S (1996). Plasminogen activator inhibitor-1 and vitronectin promote the cellular clearance of thrombin by low density lipoprotein receptor-related proteins 1 and 2. J Biol Chem , 271(14): 8215–8220 doi: 10.1074/jbc.271.14.8215 pmid:8626514
|
351 |
Stockinger W, Brandes C, Fasching D, Hermann M, Gotthardt M, Herz J, Schneider W J, Nimpf J (2000). The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and-2. J Biol Chem , 275(33): 25625–25632 doi: 10.1074/jbc.M004119200 pmid:10827199
|
352 |
Stockinger W, Hengstschl?ger-Ottnad E, Novak S, Matus A, Hüttinger M, Bauer J, Lassmann H, Schneider W J, Nimpf J (1998). The low density lipoprotein receptor gene family. Differential expression of two alpha2-macroglobulin receptors in the brain. J Biol Chem , 273(48): 32213–32221 doi: 10.1074/jbc.273.48.32213 pmid:9822699
|
353 |
Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider W J, Nimpf J (2002). The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor. EMBO J , 21(16): 4259–4267 doi: 10.1093/emboj/cdf435 pmid:12169628
|
354 |
Strickland D K, Ashcom J D, Williams S, Burgess W H, Migliorini M, Argraves W S (1990). Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem , 265(29): 17401–17404 pmid:1698775
|
355 |
Strickland D K, Kounnas M Z, Argraves W S (1995). LDL receptor-related protein: a multiligand receptor for lipoprotein and proteinase catabolism. FASEB J , 9(10): 890–898 pmid:7615159
|
356 |
Strickland D K, Ranganathan S (2003). Diverse role of LDL receptor-related protein in the clearance of proteases and in signaling. J Thromb Haemost , 1(7): 1663–1670 doi: 10.1046/j.1538-7836.2003.00330.x pmid:12871303
|
357 |
Su H P, Nakada-Tsukui K, Tosello-Trampont A C, Li Y, Bu G, Henson P M, Ravichandran K S (2002). Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem , 277(14): 11772–11779 doi: 10.1074/jbc.M109336200 pmid:11729193
|
358 |
Sundberg C, Thodeti C K, Kveiborg M, Larsson C, Parker P, Albrechtsen R, Wewer U M (2004). Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. J Biol Chem , 279(49): 51601–51611 doi: 10.1074/jbc.M403753200 pmid:15364951
|
359 |
Suzuki M, Raab G, Moses M A, Fernandez C A, Klagsbrun M (1997). Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site. J Biol Chem , 272(50): 31730–31737 doi: 10.1074/jbc.272.50.31730 pmid:9395517
|
360 |
Suzuki Y, Nagai N, Yamakawa K, Kawakami J, Lijnen H R, Umemura K (2009). Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. Blood , 114(15): 3352–3358 doi: 10.1182/blood-2009-02-203919 pmid:19608750
|
361 |
Takaguri A, Shirai H, Kimura K, Hinoki A, Eguchi K, Carlile-Klusacek M, Yang B, Rizzo V, Eguchi S (2011). Caveolin-1 negatively regulates a metalloprotease-dependent epidermal growth factor receptor transactivation by angiotensin II. J Mol Cell Cardiol , 50(3): 545–551 doi: 10.1016/j.yjmcc.2010.12.009 pmid:21172357
|
362 |
Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T (1992). Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci USA , 89(19): 9252–9256 doi: 10.1073/pnas.89.19.9252 pmid:1384047
|
363 |
Takayama Y, May P, Anderson R G, Herz J (2004). Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta). J Biol Chem , 280(18): 18504–18510 doi: 10.1074/jbc.M410265200 pmid:15753096
|
364 |
Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet J P, He X (2000). LDL-receptor-related proteins in Wnt signal transduction. Nature , 407(6803): 530–535 (In Process Citation) doi: 10.1038/35035117 pmid:11029007
|
365 |
Tarr J, Eggleton P (2005). Immune function of C1q and its modulators CD91 and CD93. Crit Rev Immunol , 25(4): 305–330 doi: 10.1615/CritRevImmunol.v25.i4.40 pmid:16167883
|
366 |
Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan-Vague I, Nalbone G, Peiretti F (2006). The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res , 312(20): 3969–3980 doi: 10.1016/j.yexcr.2006.08.027 pmid:17010968
|
367 |
Thiel K W, Carpenter G (2006). ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains. Biochem Biophys Res Commun , 350(3): 629–633 doi: 10.1016/j.bbrc.2006.09.095 pmid:17027649
|
368 |
Toledo E M, Colombres M, Inestrosa N C (2008). Wnt signaling in neuroprotection and stem cell differentiation. Prog Neurobiol , 86(3): 281–296 doi: 10.1016/j.pneurobio.2008.08.001 pmid:18786602
|
369 |
Trommsdorff M, Borg J P, Margolis B, Herz J (1998). Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem , 273(50): 33556–33560 doi: 10.1074/jbc.273.50.33556 pmid:9837937
|
370 |
Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, Hammer R E, Richardson J A, Herz J (1999). Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell , 97(6): 689–701 doi: 10.1016/S0092-8674(00)80782-5 pmid:10380922
|
371 |
Tsaroucha A K, Chatzaki E, Lambropoulou M, Despoudi K, Laftsidis P, Charsou C, Polychronidis A, Papadopoulos N, Simopoulos C E (2008). Megalin and cubilin in the human gallbladder epithelium. Clin Exp Med , 8(3): 165–170 doi: 10.1007/s10238-008-0174-y pmid:18791690
|
372 |
Tseng W F, Huang S S, Huang J S (2004). LRP-1/TbetaR-V mediates TGF-beta1-induced growth inhibition in CHO cells. FEBS Lett , 562(1-3): 71–78 doi: 10.1016/S0014-5793(04)00185-1 pmid:15044004
|
373 |
Ulery P G, Beers J, Mikhailenko I, Tanzi R E, Rebeck G W, Hyman B T, Strickland D K (2000). Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer’s disease. J Biol Chem , 275(10): 7410–7415 (In Process Citation) doi: 10.1074/jbc.275.10.7410 pmid:10702315
|
374 |
Vainio S, Heikkil? M, Kispert A, Chin N, McMahon A P (1999). Female development in mammals is regulated by Wnt-4 signalling. Nature , 397(6718): 405–409 doi: 10.1038/17068 pmid:9989404
|
375 |
van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous G J, Klumperman J, Bu G (2005). Sorting nexin 17 facilitates LRP recycling in the early endosome. EMBO J , 24(16): 2851–2861 doi: 10.1038/sj.emboj.7600756 pmid:16052210
|
376 |
Vandivier R W, Ogden C A, Fadok V A, Hoffmann P R, Brown K K, Botto M, Walport M J, Fisher J H, Henson P M, Greene K E (2002). Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells In vivo and In vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol , 169(7): 3978–3986 pmid:12244199
|
377 |
Vassar R (2001). The beta-secretase, BACE: a prime drug target for Alzheimer’s disease. J Mol Neurosci , 17(2): 157–170 doi: 10.1385/JMN:17:2:157 pmid:11816789
|
378 |
Vassar R, Bennett B D, Babu-Khan S, Kahn S, Mendiaz E A, Denis P, Teplow D B, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski M A, Biere A L, Curran E, Burgess T, Louis J C, Collins F, Treanor J, Rogers G, Citron M (1999). Beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science , 286(5440): 735–741 doi: 10.1126/science.286.5440.735 pmid:10531052
|
379 |
von Arnim C A, Kinoshita A, Peltan I D, Tangredi M M, Herl L, Lee B M, Spoelgen R, Hshieh T T, Ranganathan S, Battey F D, Liu C X, Bacskai B J, Sever S, Irizarry M C, Strickland D K, Hyman B T (2004). The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem , 280(18): 17777–17785 doi: 10.1074/jbc.M414248200 pmid:15749709
|
380 |
von Tresckow B, Kallen K J, von Strandmann E P, Borchmann P, Lange H, Engert A, Hansen H P (2004). Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. J Immunol , 172(7): 4324–4331 pmid:15034047
|
381 |
Wakabayashi T, De Strooper B (2008). Presenilins: members of the gamma-secretase quartets, but part-time soloists too. Physiology (Bethesda) , 23(4): 194–204 doi: 10.1152/physiol.00009.2008 pmid:18697993
|
382 |
Wakatsuki S, Kurisaki T, Sehara-Fujisawa A (2004). Lipid rafts identified as locations of ectodomain shedding mediated by Meltrin beta/ADAM19. J Neurochem , 89(1): 119–123 doi: 10.1046/j.1471-4159.2003.02303.x pmid:15030395
|
383 |
Wang X, Lee S R, Arai K, Lee S R, Tsuji K, Rebeck G W, Lo E H (2003). Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med , 9(10): 1313–1317 doi: 10.1038/nm926 pmid:12960961
|
384 |
Weaver A M, Hussaini I M, Mazar A, Henkin J, Gonias S L (1997). Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. J Biol Chem , 272(22): 14372–14379 doi: 10.1074/jbc.272.22.14372 pmid:9162074
|
385 |
Weeber E J, Beffert U, Jones C, Christian J M, Forster E, Sweatt J D, Herz J (2002). Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem , 277(42): 39944–39952 doi: 10.1074/jbc.M205147200 pmid:12167620
|
386 |
Weeraratna A T, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, Trent J M (2002). Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell , 1(3): 279–288 doi: 10.1016/S1535-6108(02)00045-4 pmid:12086864
|
387 |
Wehrli M, Dougan S T, Caldwell K, O’Keefe L, Schwartz S, Vaizel-Ohayon D, Schejter E, Tomlinson A, DiNardo S (2000). arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature , 407(6803): 527–530 (In Process Citation) doi: 10.1038/35035110 pmid:11029006
|
388 |
Wicher G, Aldskogius H (2008). Megalin deficiency induces critical changes in mouse spinal cord development. Neuroreport , 19(5): 559–563 doi: 10.1097/WNR.0b013e3282f94267 pmid:18388738
|
389 |
Wicher G, Larsson M, Fex Svenningsen A, Gyllencreutz E, Rask L, Aldskogius H (2006). Low density lipoprotein receptor-related protein-2/megalin is expressed in oligodendrocytes in the mouse spinal cord white matter. J Neurosci Res , 83(5): 864–873 doi: 10.1002/jnr.20774 pmid:16463279
|
390 |
Wicher G, Larsson M, Rask L, Aldskogius H (2005). Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cord. J Comp Neurol , 492(2): 123–131 doi: 10.1002/cne.20673 pmid:16196028
|
391 |
Willert K, Nusse R (1998). Beta-catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev , 8(1): 95–102 doi: 10.1016/S0959-437X(98)80068-3 pmid:9529612
|
392 |
Willnow T E (1999). The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism. J Mol Med (Berl) , 77(3): 306–315 (see comments) doi: 10.1007/s001090050356 pmid:10090593
|
393 |
Willnow T E, Hilpert J, Armstrong S A, Rohlmann A, Hammer R E, Burns D K, Herz J (1996a). Defective forebrain development in mice lacking gp330/megalin. Proc Natl Acad Sci USA , 93(16): 8460–8464 doi: 10.1073/pnas.93.16.8460 pmid:8710893
|
394 |
Willnow T E, Moehring J M, Inocencio N M, Moehring T J, Herz J (1996b). The low-density-lipoprotein receptor-related protein (LRP) is processed by furin In vivo and In vitro. Biochem J , 313(Pt 1): 71–76 pmid:8546712
|
395 |
Willnow T E, Nykjaer A, Herz J (1999). Lipoprotein receptors: new roles for ancient proteins. Nat Cell Biol , 1(6): E157–E162 doi: 10.1038/14109 pmid:10559979
|
396 |
Willnow T E, Rohlmann A, Horton J, Otani H, Braun J R, Hammer R E, Herz J (1996c). RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. EMBO J , 15(11): 2632–2639 pmid:8654360
|
397 |
Wodarz A, Nusse R (1998). Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol , 14(1): 59–88 doi: 10.1146/annurev.cellbio.14.1.59 pmid:9891778
|
398 |
Wolff N A, Abouhamed M, Verroust P J, Thévenod F (2006). Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. J Pharmacol Exp Ther , 318(2): 782–791 doi: 10.1124/jpet.106.102574 pmid:16690719
|
399 |
Wu G, Huang H, Garcia Abreu J, He X (2009). Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS ONE , 4(3): e4926 doi: 10.1371/journal.pone.0004926 pmid:19293931
|
400 |
Wygrecka M, Wilhelm J, Jablonska E, Zakrzewicz D, Preissner K T, Seeger W, Guenther A, Markart P (2011). Shedding of Low Density Lipoprotein Receptor-related Protein-1 in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med: Xu X X, Yi T, Tang B, Lambeth J D (1998). Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene , 16(12): 1561–1569
|
401 |
Yang D H, Cai K Q, Roland I H, Smith E R, Xu X X (2007). Disabled-2 is an epithelial surface positioning gene. J Biol Chem , 282(17): 13114–13122 doi: 10.1074/jbc.M611356200 pmid:17339320
|
402 |
Xu X X, Yi T, Tang B, Lambeth J D (1998). Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene , 16(12): 1561–1569
|
403 |
Yang M, Huang H, Li J, Li D, Wang H (2004). Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. FASEB J , 18(15): 1920–1921 pmid:15469966
|
404 |
Yang Z, Cool B H, Martin G M, Hu Q (2006). A dominant role for FE65 (APBB1) in nuclear signaling. J Biol Chem , 281(7): 4207–4214 doi: 10.1074/jbc.M508445200 pmid:16332686
|
405 |
Yang Z, Strickland D K, Bornstein P (2001). Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2. J Biol Chem , 276(11): 8403–8408 doi: 10.1074/jbc.M008925200 pmid:11113133
|
406 |
Yasui N, Nogi T, Takagi J (2010). Structural basis for specific recognition of reelin by its receptors. Structure , 18(3): 320–331 doi: 10.1016/j.str.2010.01.010 pmid:20223215
|
407 |
Yepes M, Sandkvist M, Moore E G, Bugge T H, Strickland D K, Lawrence D A (2003). Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest , 112(10): 1533–1540 pmid:14617754
|
408 |
Yokozeki T, Wakatsuki S, Hatsuzawa K, Black R A, Wada I, Sehara-Fujisawa A (2007). Meltrin beta (ADAM19) mediates ectodomain shedding of Neuregulin beta1 in the Golgi apparatus: fluorescence correlation spectroscopic observation of the dynamics of ectodomain shedding in living cells. Genes Cells , 12(3): 329–343 doi: 10.1111/j.1365-2443.2007.01060.x pmid:17352738
|
409 |
Yoshikawa S, McKinnon R D, Kokel M, Thomas J B (2003). Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature , 422(6932): 583–588 doi: 10.1038/nature01522 pmid:12660735
|
410 |
Young H M, Anderson R B, Anderson C R (2004). Guidance cues involved in the development of the peripheral autonomic nervous system. Auton Neurosci , 112(1-2): 1–14 doi: 10.1016/j.autneu.2004.02.008 pmid:15233925
|
411 |
Yuseff M I, Farfan P, Bu G, Marzolo M P (2007). A cytoplasmic PPPSP motif determines megalin’s phosphorylation and regulates receptor’s recycling and surface expression. Traffic , 8(9): 1215–1230 doi: 10.1111/j.1600-0854.2007.00601.x pmid:17555532
|
412 |
Zambrano N, Minopoli G, de Candia P, Russo T (1998). The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. J Biol Chem , 273(32): 20128–20133 doi: 10.1074/jbc.273.32.20128 pmid:9685356
|
413 |
Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh J C, He X (2007). Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development , 135(2): 367–375 doi: 10.1242/dev.013540 pmid:18077588
|
414 |
Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X (2005). A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature , 438(7069): 873–877 doi: 10.1038/nature04185 pmid:16341017
|
415 |
Zeng Y A, Nusse R (2010). Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell , 6(6): 568–577 doi: 10.1016/j.stem.2010.03.020 pmid:20569694
|
416 |
Zerbinatti C V, Wozniak D F, Cirrito J, Cam J A, Osaka H, Bales K R, Zhuo M, Paul S M, Holtzman D M, Bu G (2004). Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Natl Acad Sci USA , 101(4): 1075–1080 doi: 10.1073/pnas.0305803101 pmid:14732699
|
417 |
Zhang C, An J, Haile W B, Echeverry R, Strickland D K, Yepes M (2009). Microglial low-density lipoprotein receptor-related protein 1 mediates the effect of tissue-type plasminogen activator on matrix metalloproteinase-9 activity in the ischemic brain. J Cereb Blood Flow Metab , 29(12): 1946–1954 doi: 10.1038/jcbfm.2009.174 pmid:19672275
|
418 |
Zhang Q, Thomas S M, Lui V W, Xi S, Siegfried J M, Fan H, Smithgall T E, Mills G B, Grandis J R (2006). Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci USA , 103(18): 6901–6906 doi: 10.1073/pnas.0509719103 pmid:16641105
|
419 |
Zheng G, Marino’ M, Zhao J, McCluskey R T (1998). Megalin (gp330): a putative endocytic receptor for thyroglobulin (Tg). Endocrinology , 139(3): 1462–1465 doi: 10.1210/en.139.3.1462 pmid:9492085
|
420 |
Zheng Y, Schlondorff J, Blobel C P (2002). Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem , 277(45): 42463–42470 doi: 10.1074/jbc.M207459200 pmid:12207026
|
421 |
Zhou J, Hsieh J T (2001). The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2. J Biol Chem , 276(30): 27793–27798 doi: 10.1074/jbc.M102803200 pmid:11371563
|
422 |
Zhu Y, Hui D Y (2003). Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A. J Biol Chem , 278(38): 36257–36263 doi: 10.1074/jbc.M303171200 pmid:12857755
|
423 |
Zhuo M, Holtzman D M, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G (2000). Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. J Neurosci , 20(2): 542–549 pmid:10632583
|
424 |
Zimina E P, Bruckner-Tuderman L, Franzke C W (2005). Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment. J Biol Chem , 280(40): 34019–34024 doi: 10.1074/jbc.M503751200 pmid:16020548
|
425 |
Zlokovic B V, Martel C L, Matsubara E, McComb J G, Zheng G, McCluskey R T, Frangione B, Ghiso J (1996). Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci USA , 93(9): 4229–4234 doi: 10.1073/pnas.93.9.4229 pmid:8633046
|
426 |
Zou Z, Chung B, Nguyen T, Mentone S, Thomson B, Biemesderfer D (2004). Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. J Biol Chem , 279(33): 34302–34310 doi: 10.1074/jbc.M405608200 pmid:15180987
|
427 |
Zurhove K, Nakajima C, Herz J, Bock H H, May P (2008). Gamma-secretase limits the inflammatory response through the processing of LRP1. Sci Signal , 1(47): ra15 doi: 10.1126/scisignal.1164263 pmid:19036715
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