The super super-healing MRL mouse strain

doi:10.1007/s11515-012-1192-4

Front Biol

2012, Vol. 7

Issue (6) : 522-538 https://doi.org/10.1007/s11515-012-1192-4

REVIEW

The super super-healing MRL mouse strain

Ahlke HEYDEMANN(

)

Department of Physiology and Biophysics, Center for Cardiovascular Research, The University of Illinois at Chicago, Chicago, IL 60612, USA

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Abstract

The Murphy Roths Large (MRL/MpJ) mice provide unique insights into wound repair and regeneration. These mice and the closely related MRL/MpJ-Fas^lpr/J and Large strains heal wounds made in multiple tissues without production of a fibrotic scar. The precise mechanism of this remarkable ability still eludes researchers, but some data has been generated and insights are being revealed. For example, MRL cells reepithelialize over dermal wound sites faster than cells of other mouse strains. This allows a blastema to develop beneath the protective layer. The MRL mice also have an altered basal immune system and an altered immune response to injury. In addition, MRL mice have differences in their tissue resident progenitor cells and certain cell cycle regulatory proteins. The difficulty often lies in separating the causative differences from the corollary differences. Remarkably, not every tissue in these mice heals scarlessly, and the specific type of wound and priming affect regeneration ability as well. The MRL/MpJ, MRL/MpJ-Fas^lpr/J, and Large mouse strains are also being investigated for their autoimmune characteristic. Whether the two phenotypes of regeneration and autoimmunity are related remains an enigma.

Keywords MRL wound healing regeneration

Corresponding Author(s): HEYDEMANN Ahlke,Email:ahlkeh@uic.edu

Issue Date: 01 December 2012

Cite this article:

Ahlke HEYDEMANN. The super super-healing MRL mouse strain[J]. Front Biol, 2012, 7(6): 522-538.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-012-1192-4
https://academic.hep.com.cn/fib/EN/Y2012/V7/I6/522

Fig.1

Fig.2

Fig.3

Fig.4 Electron micrographs demonstrating aberrant mitochondria in the MRL/MpJ mouse strain quadriceps, compared to the DBA/2J control strain. Note the standard arrangement of interfibril mitochondrial pairs in the control quadriceps (black arrows) and the increased number of mitochondria at this anatomical position in the MRL/MpJ strain (black arrowheads). Some of the MRL/MpJ mitochondria also demonstrate abnormal shapes (white arrows) and lipid-like inclusion bodies (asterisk). Top panels’ bar is 2 μm, bottom panels’ bar is 1 μm.

Fig.5 Table4 Ear hole healing associated quantitative trait loci

Fig.6 Schematic of possible mechanisms altering the wound healing properties of MRL/MpJ animals.

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