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Frontiers in Biology

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Front Biol    2013, Vol. 8 Issue (4) : 387-394    https://doi.org/10.1007/s11515-013-1267-x
REVIEW
Universal soldier: Pseudomonas aeruginosa – an opportunistic generalist
Jeremy GROSS1, Ian J. PASSMORE1, Jade C. S. CHUNG1, Olena RZHEPISHEVSKA2, Madeleine RAMSTEDT2, Martin WELCH1()
1. Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK; 2. Department of Chemistry, Ume? University, Ume? 901 87, Sweden
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Abstract

The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis (CF). P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a “natural” ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen.
Keywords Pseudomonas aeruginosa      cystic fibrosis      evolution      adaptive radiation      antibiotic resistance      quorum sensing     
Corresponding Author(s): WELCH Martin,Email:mw240@cam.ac.uk   
Issue Date: 01 August 2013
 Cite this article:   
Jeremy GROSS,Ian J. PASSMORE,Jade C. S. CHUNG, et al. Universal soldier: Pseudomonas aeruginosa – an opportunistic generalist[J]. Front Biol, 2013, 8(4): 387-394.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-013-1267-x
https://academic.hep.com.cn/fib/EN/Y2013/V8/I4/387
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