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Laboratory diagnosis for malaria in the elimination phase in China: efforts and challenges |
Jianhai Yin(), Mei Li, He Yan, Shuisen Zhou, Zhigui Xia() |
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China |
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Abstract Malaria remains a global health challenge, although an increasing number of countries will enter pre-elimination and elimination stages. The prompt and precise diagnosis of symptomatic and asymptomatic carriers of Plasmodium parasites is the key aspect of malaria elimination. Since the launch of the China Malaria Elimination Action Plan in 2010, China has formulated clear goals for malaria diagnosis and has established a network of malaria diagnostic laboratories within medical and health institutions at all levels. Various external quality assessments were implemented, and a national malaria diagnosis reference laboratory network was established to strengthen the quality assurance in malaria diagnosis. Notably, no indigenous malaria cases have been reported since 2017, but the risk of re-establishment of malaria transmission cannot be ignored. This review summarizes the lessons about malaria diagnosis in the elimination phase, primarily including the establishments of laboratory networks and quality control in China, to better improve malaria diagnosis and maintain a malaria-free status. A reference is also provided for countries experiencing malaria elimination.
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Keywords
malaria
laboratory diagnosis
quality control
malaria elimination
China
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Corresponding Author(s):
Jianhai Yin,Zhigui Xia
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Just Accepted Date: 19 January 2022
Online First Date: 25 February 2022
Issue Date: 28 March 2022
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|
1 |
WHO. World malaria report 2020: 20 years of global progress and challenges. Geneva: World Health Organization, 2020
|
2 |
WHO. World malaria report 2019. Geneva: World Health Organization, 2019
|
3 |
LH Tang, LQ Xu, YD Chen. Parasitic Disease Control and Research in China. Beijing: Beijing Science & Technology Press, 2012 (in Chinese)
|
4 |
JH Yin, SS Zhou, ZG Xia, RB Wang, YJ Qian, WZ Yang, XN Zhou. Historical patterns of malaria transmission in China. Adv Parasitol 2014; 86: 1–19
https://doi.org/10.1016/B978-0-12-800869-0.00001-9
pmid: 25476879
|
5 |
Ministry of Health, the People’s Republic of China. China Malaria Elimination Action Plan (2010–2020). 2010 (in Chinese)
|
6 |
L Zhang, J Feng, SS Zhang, ZG Xia, SS Zhou. The progress of national malaria elimination and epidemiological characteristics of malaria in China in 2017. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2018; 36(3): 201–209 (in Chinese)
|
7 |
WHO. From 30 million cases to zero: China is certified malaria-free by WHO.
|
8 |
malERA Consultative Group on Diagnoses and Diagnostics. A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med 2011; 8(1): e1000396
https://doi.org/10.1371/journal.pmed.1000396
pmid: 21311583
|
9 |
WHO. Universal access to malaria diagnostic testing: an operational manual. Geneva: World Health Organization, 2011
|
10 |
J Yin, L Zhang, J Feng, S Zhou, Z Xia. Malaria diagnosis and verification—China, 2017–2018. China CDC Wkly 2020; 2(17): 285–288
https://doi.org/10.46234/ccdcw2020.073
pmid: 34594640
|
11 |
JH Yin, H Yan, F Huang, M Li, HH Xiao, SS Zhou, ZG Xia. Establishing a China malaria diagnosis reference laboratory network for malaria elimination. Malar J 2015; 14(1): 40
https://doi.org/10.1186/s12936-015-0556-z
pmid: 25628071
|
12 |
J Yin, H Yan, M Li, Y Ruan, X Zhang, L Wang, C Cao, Z Xia, S Zhou. Competency and challenges in malaria microscopy in China. Biosci Trends 2017; 11(6): 702–705
https://doi.org/10.5582/bst.2017.01275
pmid: 29311452
|
13 |
National Institute of Parasitic Diseases, China CDC. The pre-review of the provincial reference laboratory for malaria diagnosis in Ningxia. (in Chinese) (accessed November 3, 2020)
|
14 |
SS Zhou, Y Wang, Y Li. Malaria situation in the People’s Republic of China in 2010. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2011; 29(6): 401–403 (in Chinese)
pmid: 24822335
|
15 |
ZG Xia, MN Yang, SS Zhou. Malaria situation in the People’s Republic of China in 2011. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2012; 30(6): 419–422 (in Chinese)
pmid: 23484249
|
16 |
ZG Xia, J Feng, SS Zhou. Malaria situation in the People’s Republic of China in 2012. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2013; 31(6): 413–418 (in Chinese)
pmid: 24818404
|
17 |
L Zhang, J Feng, ZG Xia. Malaria situation in the People’s Republic of China in 2013. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2014; 32(6): 407–413 (in Chinese)
pmid: 25902667
|
18 |
G Ding, G Zhu, C Cao, P Miao, Y Cao, W Wang, Y Gu, S Xu, S Wang, H Zhou, J Cao. The challenge of maintaining microscopist capacity at basic levels for malaria elimination in Jiangsu Province, China. BMC Public Health 2018; 18(1): 489
https://doi.org/10.1186/s12889-018-5307-y
pmid: 29650008
|
19 |
Ministry of Health, the People’s Republic of China. Diagnostic Criteria for Malaria (WS 259-2006). 2006 (in Chinese)
|
20 |
National Health and Planning of the People’s Republic of China. Diagnosis of malaria (WS 259-2015). 2015 (in Chinese)
|
21 |
National Health and Planning of the People’s Republic of China. Microscopic examination of blood films for malaria parasites (WS/T 569-2017). 2017 (in Chinese)
|
22 |
Q Fu, SZ Li, Q Wang, L Zhang, W Liu, X Zheng, SS Zhang, ZG Xia, SS Zhou, Z Chen, LY Wang, XN Zhou. Report of analysis of National Technique Competition for Diagnosis of Parasitic Diseases in 2011—II Analysis of capabilities of Plasmodium detection. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2012; 24(3): 274–278 (in Chinese)
pmid: 23012948
|
23 |
Y Ruan, T Tian, Z Zhu, Y Hao, L Zhang, T Zhu, L Wang, Q Wang, C Cao, S Li, X Zhou. Assessing competence for helminthiases: a lesson learnt from national contest of parasitic diseases in China in 2012–2016. Acta Trop 2019; 198: 105078
https://doi.org/10.1016/j.actatropica.2019.105078
pmid: 31299284
|
24 |
M Li, H Zhou, H Yan, J Yin, X Feng, Z Xia, S Zhou. Analysis on external competency assessment for malaria microscopists in China. Malar J 2019; 18(1): 366
https://doi.org/10.1186/s12936-019-2996-3
pmid: 31727074
|
25 |
WHO. Malaria microscopy quality assurance manual (Version 1). Geneva: World Health Organization, 2009
|
26 |
WHO. Malaria microscopy quality assurance manual (Version 2). Geneva: World Health Organization, 2016
|
27 |
J Yin, H Yan, M Li, W Fang, F Huang, W Jiang, S Zhou, Z Xia. Malaria diagnosis reference laboratory: analysis of malaria detecting ability under microscope in the External Quality Assurance Program. Int J Med Parasit Dis (Guo Ji Yi Xue Ji Sheng Chong Bing Za Zhi) 2015; 42(3): 173–175 (in Chinese)
|
28 |
JA Cunningham, RM Thomson, SC Murphy, M de la Paz Ade, XC Ding, S Incardona, E Legrand, NW Lucchi, D Menard, SL Nsobya, AC Saez, PL Chiodini, J Shrivastava. WHO malaria nucleic acid amplification test external quality assessment scheme: results of distribution programmes one to three. Malar J 2020; 19(1): 129
https://doi.org/10.1186/s12936-020-03200-0
pmid: 32228615
|
29 |
L Fei, Z Shuang, Y Yi, L Shan-Shan, T Yan, X Jing-Ru, Z Yang. Assessment of malaria microscopy competency at primary health institutions in the Chongqing Municipality. Front Med (Lausanne) 2021; 8: 602442
https://doi.org/10.3389/fmed.2021.602442
pmid: 33791321
|
30 |
Y Dong, XH Mao, MN Chen, Y Deng, J Wang, YC Xu. Quality analysis of laboratory malaria diagnosis in Yunnan Province during 2012–2014. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2015; 33(3): 191–195 (in Chinese)
pmid: 26541035
|
31 |
DY She, JH Wu, LD Lu, YT Huang, Y Geng, NH Zhang. Evaluation of the testing ability of city/prefecture-level malaria laboratories in Guizhou Province during 2014–2016. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2017; 35(5): 466–471 (in Chinese)
|
32 |
LC Sun, DN Wu, XR Dong, Z Tu, W Lin, J Xia. Results of Hubei provincial malaria diagnostic reference laboratory from 2014 to 2018. Chin J Dis Control Prev (Zhonghua Ji Bing Kong Zhi Za Zhi) 2021; 25(1): 108–112 (in Chinese)
|
33 |
Y Deng, Y Dong, YC Xu, XH Mao, MN Chen. Quality and impact factors of malaria diagnosis in Yunnan provincial laboratory from 2015 to 2016. Chin J Zoonoses (Zhongguo Ren Shou Gong Huan Bing Xue Bao) 2018; 34(4): 337–342 (in Chinese)
|
34 |
LC Sun, XR Dong, Z Tu, DN Wu, W Lin, XR Zhou, H Zhu. Re-examination of malaria diagnosis in Hubei provincial malaria diagnostic reference laboratory from 2017 to 2019. Chin J Schisto Control (Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi) 2020; 32(6): 631–634 (in Chinese)
pmid: 33325200
|
35 |
S Xu, YP Gu, YY Cao, WM Wang, JX Tang, JL Li, MH Zhang, HY Zhou, GD Zhu, J Cao. Results analysis of Jiangsu provincial malaria diagnostic reference laboratory in 2017. Chin J Schisto Control (Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi) 2018; 30(6): 630–634 (in Chinese)
|
36 |
National Institute of Parasitic Diseases, China CDC. The national quality assessment of malaria blood smear preparation and microscopic examination, 2020. (in Chinese) (accessed December 25, 2020)
|
37 |
L Zhang, J Feng, SS Zhang, ZG Xia, SS Zhou. Epidemiological characteristics of malaria and the progress towards its elimination in China in 2018. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2019; 37(3): 241–247 (in Chinese)
|
38 |
L Zhang, J Feng, ZG Xia, SS Zhou. Epidemiological characteristics of malaria and progress on its elimination in China in 2019. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2020; 38(2): 133–138 (in Chinese)
|
39 |
L Zhang, J Feng, H Tu, J Yin, ZG Xia. Malaria epidemiology in China in 2020. Chin J Parasitol Parasit Dis (Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi) 2021; 39(2): 195–199 (in Chinese)
|
40 |
L Ayong, CEE Moukoko, WF Mbacham. Diagnosing malaria: methods, tools, and field applicability. Methods Mol Biol 2019; 2013: 73–82
https://doi.org/10.1007/978-1-4939-9550-9_5
pmid: 31267494
|
41 |
T Bousema, L Okell, I Felger, C Drakeley. Asymptomatic malaria infections: detectability, transmissibility and public health relevance. Nat Rev Microbiol 2014; 12(12): 833–840
https://doi.org/10.1038/nrmicro3364
pmid: 25329408
|
42 |
J Cheaveau, DC Mogollon, MAN Mohon, L Golassa, D Yewhalaw, DR Pillai. Asymptomatic malaria in the clinical and public health context. Expert Rev Anti Infect Ther 2019; 17(12): 997–1010
https://doi.org/10.1080/14787210.2019.1693259
pmid: 31718324
|
43 |
D Gamboa, MF Ho, J Bendezu, K Torres, PL Chiodini, JW Barnwell, S Incardona, M Perkins, D Bell, J McCarthy, Q Cheng. A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests. PLoS One 2010; 5(1): e8091
https://doi.org/10.1371/journal.pone.0008091
pmid: 20111602
|
44 |
WHO. False-negative RDT results and implications of new reports of P. falciparum histidine-rich protein 2/3 gene deletions. Geneva: World Health Organization, 2017
|
45 |
R Thomson, JB Parr, Q Cheng, S Chenet, M Perkins, J Cunningham. Prevalence of Plasmodium falciparum lacking histidine-rich proteins 2 and 3: a systematic review. Bull World Health Organ 2020; 98(8): 558–568F
https://doi.org/10.2471/BLT.20.250621
pmid: 32773901
|
46 |
The State Council of the People’s Republic of China. Notice on the Work Plan for Further Promoting the Capacity Building of the COVID-19 Nucleic Acid Amplification Testing Issued by the State Council’s Joint Prevention and Control Mechanism in Response to the COVID-19. (in Chinese) (accessed August 31, 2020)
|
47 |
L Zhang, H Tu, S Zhou, Z Xia, J Feng. Malaria deaths—China, 2011–2020. China CDC Wkly 2021; 3(17): 360–365
https://doi.org/10.46234/ccdcw2021.098
pmid: 34594884
|
48 |
W Li, T Zhang, X Xu, J Jiang, C Yu, C Tian, S Wang, X Lyu, Z Liu. Problems associated with the diagnosis of imported malaria in Anhui Province, China. Am J Trop Med Hyg 2020; 102(1): 142–146
https://doi.org/10.4269/ajtmh.19-0471
pmid: 31701862
|
49 |
LQ Fang, Y Sun, GP Zhao, LJ Liu, ZJ Jiang, ZW Fan, JX Wang, Y Ji, MJ Ma, J Teng, Y Zhu, P Yu, K Li, YJ Tian, WC Cao. Travel-related infections in mainland China, 2014–16: an active surveillance study. Lancet Public Health 2018; 3(8): e385–e394
https://doi.org/10.1016/S2468-2667(18)30127-0
pmid: 30033200
|
50 |
WMKTAW Gunasekera, R Premaratne, D Fernando, M Munaz, MGY Piyasena, D Perera, R Wickremasinghe, KDNP Ranaweera, K Mendis. A comparative analysis of the outcome of malaria case surveillance strategies in Sri Lanka in the prevention of re-establishment phase. Malar J 2021; 20(1): 80
https://doi.org/10.1186/s12936-021-03621-5
pmid: 33563273
|
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