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Why sex differences in schizophrenia? |
| Rena Li1,2,3*, Xin Ma1, Gang Wang1, Jian Yang1, Chuanyue Wang1,2 |
1. Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital Capital Medical University, Beijing 100088, China;
2. Center of Schizophrenia, Beijing Institute for Brain Disorders, Beijing 100069, China;
3. Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA |
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Abstract Clinical observation shows that men and women are different in prevalence, symptoms, and responses to treatment of several psychiatric disorders, including schizophrenia. While the etiology of gender differences in schizophrenia is only partially understood, recent genetic studies suggest significant sex-specific pathways in the schizophrenia between men and women. More research is needed to understand the causal roles of sex differences in schizophrenia in order to ultimately develop sex-specific treatment of this serious mental illness. In the present review, we will outline the current evidence on the sex-related factors interaction with disease onset, symptoms and treatment of schizophrenia, and discuss the potential molecular mechanisms that may mediate their cooperative actions in schizophrenia pathogenesis.
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schizophrenia
gender-related factor
sex-specific treatment
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Corresponding Author(s):
*Rena Li, E-mail:renali@ccmu.edu.cn
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Issue Date: 14 October 2016
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