Special Topic: Research Progress of Schizophrenia Related Genes |
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Research progress on the mechanism of N6-methyladenosine methylation modification and proteolipid protein 1 gene in schizophrenia |
Zhilan Yang, Hongying Pan, Lan Jiang, Tiankai Jiang, Yinhang Li, Jie Wu* |
Department of Clinical Psychology, The Affiliated Mental Hospital of Kunming Medical University, Kunming 650000, China |
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Abstract Schizophrenia (SCZ) is a serious mental illness with unknown etiology, high recurrence rate and high disability rate, which has caused a great burden to individuals and society. There is no clear etiology and pathogenesis. Methylation of N6-methyladenosine (m6A) can regulate the nervous and mental system, and affect the function of the nervous system. Proteolipid protein 1 (PLP1) is a risk gene for schizophrenia. In this study we review the research progress on the pathogenesis of schizophrenia, m6A methylation, and PLP1 gene.
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Keywords
schizophrenia (SCZ)
methylation of N6-methyladenosine (m6A)
proteolipid protein 1 (PLP1)
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Issue Date: 23 November 2022
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