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Protein & Cell

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ISSN 1674-8018(Online)

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Prot Cell    2012, Vol. 3 Issue (10) : 739-754    https://doi.org/10.1007/s13238-012-2072-z      PMID: 22983904
REVIEW
Aptamer-based molecular imaging
Tianjiao Wang(), Judhajeet Ray
Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
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Abstract

Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living organisms. Aptamers, short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically, are ideal molecular recognition elements for probe development in molecular imaging. This review summarizes the current state of aptamer-based biosensor development (probe design and imaging modalities) and their application in imaging small molecules, nucleic acids and proteins mostly in a cellular context with some animal studies. The article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.
Keywords aptamer      imaging      small molecule      nucleic acid      protein      biosensor     
Corresponding Author(s): Wang Tianjiao,Email:tjwang@iastate.edu   
Issue Date: 01 October 2012
 Cite this article:   
Tianjiao Wang,Judhajeet Ray. Aptamer-based molecular imaging[J]. Prot Cell, 2012, 3(10): 739-754.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2072-z
https://academic.hep.com.cn/pac/EN/Y2012/V3/I10/739
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