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Protein & Cell

ISSN 1674-800X

ISSN 1674-8018(Online)

CN 11-5886/Q

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Prot Cell    2012, Vol. 3 Issue (10) : 762-768    https://doi.org/10.1007/s13238-012-2058-x      PMID: 22983902
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Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling
Kai Gong1, Fangfang Zhou1,2(), Huizhe Huang1,3, Yandao Gong1, Long Zhang2()
1. Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China; 2. Leiden University Medical Center, Department of Molecular Cell Biology, Leiden, the Netherland; 3. Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China
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Abstract

We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) by using RAW264.7 cells. LPS rapidly stimulated cytosolic β-catenin accumulation. β-catenin mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activationprimed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation. Overall, our findings suggest that suppression of GSK3β by ERK stimulates β-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.
Keywords LPS      ERK      GSK3b      b-catenin      cell migration     
Corresponding Author(s): Zhou Fangfang,Email:F.zhou@lumc.nl; Zhang Long,Email:L.zhang@lumc.nl   
Issue Date: 01 October 2012
 Cite this article:   
Kai Gong,Fangfang Zhou,Huizhe Huang, et al. Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling[J]. Prot Cell, 2012, 3(10): 762-768.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2058-x
https://academic.hep.com.cn/pac/EN/Y2012/V3/I10/762
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