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Frontiers of Agricultural Science and Engineering

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Front. Agr. Sci. Eng.    2020, Vol. 7 Issue (2) : 123-128    https://doi.org/10.15302/J-FASE-2019309
REVIEW
A brief review of genome editing technology for generating animal models
Haoyi WANG1,2,3(), Sen WU4,5(), Mario R. CAPECCHI6(), Rudolf JAENISCH7,8()
1. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
2. University of the Chinese Academy of Sciences, Beijing 100049, China
3. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China
4. Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China
5. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China
6. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
7. Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
8. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
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Abstract

The recent development of genome editing technologies has given researchers unprecedented power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animal models. This mini-review briefly summarizes the development of major genome editing tools, focusing on the application of these tools to generate animal models in multiple species.
Keywords animal model      CRISPR      genome editing      TALEN      ZFN     
Corresponding Author(s): Haoyi WANG,Sen WU,Mario R. CAPECCHI,Rudolf JAENISCH   
Just Accepted Date: 21 February 2020   Online First Date: 16 March 2020    Issue Date: 28 April 2020
 Cite this article:   
Haoyi WANG,Sen WU,Mario R. CAPECCHI, et al. A brief review of genome editing technology for generating animal models[J]. Front. Agr. Sci. Eng. , 2020, 7(2): 123-128.
 URL:  
https://academic.hep.com.cn/fase/EN/10.15302/J-FASE-2019309
https://academic.hep.com.cn/fase/EN/Y2020/V7/I2/123
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