Discovery of emerging organic pollutants in the atmosphere through an omics approach

doi:10.1007/s11783-023-1645-9

Front. Environ. Sci. Eng.

2023, Vol. 17

Issue (4) : 45 https://doi.org/10.1007/s11783-023-1645-9

REVIEW ARTICLE

Discovery of emerging organic pollutants in the atmosphere through an omics approach

Zhen Cheng, Xinghua Qiu(

), Xiaodi Shi, Xing Jiang, Tong Zhu

State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing 100871, China

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Abstract

● We review the framework of discovering emerging pollutants through an omics approach.

● High-resolution MS can digitalize atmospheric samples to full-component data.

● Chemical features and databases can help to translate untargeted data to compounds.

● Biological effect-directed untargeted analyses consider both existence and toxicity.

Ambient air pollution, containing numerous known and hitherto unknown compounds, is a major risk factor for public health. The discovery of harmful components is the prerequisite for pollution control; however, this raises a great challenge on recognizing previously unknown species. Here we systematically review the analytical techniques on air pollution in the framework of an omics approach, with a brief introduction on sample preparation and analysis, and in more detail, compounds prioritization and identification. Through high-resolution mass spectrometry (HRMS, typically coupled with chromatography), the complicated environmental matrix can be digitalized into “full-component” data. A key step to discover emerging compounds is the prioritization of compounds from massive data. Chemical fingerprints, suspect lists and biological effects are the most vital untargeted strategies for comprehensively screening critical and hazardous substances. Afterward, compressed data of compounds can be identified at various confidence levels according to exact mass and the derived molecular formula, MS libraries, and authentic standards. Such an omics approach on full-component data provides a paradigm for discovering emerging air pollutants; nonetheless, new technological advancements of instruments and databases are warranted for further tracking the environmental behaviors, hence to evaluate the health risk of key pollutants.

Keywords Air pollution Emerging pollutants Full-component High-resolution mass spectrometry Omics approach

Corresponding Author(s): Xinghua Qiu

Issue Date: 24 October 2022

Cite this article:

Zhen Cheng,Xinghua Qiu,Xiaodi Shi, et al. Discovery of emerging organic pollutants in the atmosphere through an omics approach[J]. Front. Environ. Sci. Eng., 2023, 17(4): 45.

URL:

https://academic.hep.com.cn/fese/EN/10.1007/s11783-023-1645-9
https://academic.hep.com.cn/fese/EN/Y2023/V17/I4/45

Fig.1 A general scheme of the omics approach.

Fig.2 Various untargeted strategies emphasizing different known or unknown compounds (i.e., knowns or unknowns) from full-component data. Compound-originated suspect and untargeted screening generally focus on their environmental existence, whereas biological effect-directed analysis considers both existence and toxicity.

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