Multi-omics in nanoplastic research: a spotlight on aquatic life

doi:10.1007/s11783-024-1893-3

Front. Environ. Sci. Eng.

2024, Vol. 18

Issue (11) : 133 https://doi.org/10.1007/s11783-024-1893-3

Multi-omics in nanoplastic research: a spotlight on aquatic life

Mohamed Helal^1,², Min Liu³, Honghong Chen^4,^5,⁶, Mingliang Fang^3,⁷, Wenhui Qiu⁴, Frank Kjeldsen⁸, Knut Erik Tollefsen^9,¹⁰, Vengatesen Thiyagarajan¹¹, Henrik Holbech¹, Elvis Genbo Xu¹(

)

¹. Department of Biology, University of Southern Denmark, Odense 5230, Denmark
². National Institute of Oceanography and Fisheries (NIOF), Cairo 11865, Egypt
³. School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore
⁴. Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China
⁵. Eastern Institute for Advanced Study, Eastern Institute of Technology, Ningbo 315200, China
⁶. School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
⁷. Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China
⁸. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M 5230, Denmark
⁹. Norwegian Institute for Water Research (NIVA), Oslo N-0579, Norway
¹⁰. Norwegian University of Life Sciences (NMBU), Ås N-1432, Norway
¹¹. The Swire Institute of Marine Sciences, School of Biological Sciences, The University of Hong Kong, Hong Kong 999077, China

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Abstract

● We integrate omics data to analyze the aquatic toxicodynamics of nanoplastics.

● Transcriptomics is the primary omics tool in aquatic nanoplastic toxicology research.

● Metabolic disruption, oxidative stress, & photosynthesis inhibition are key effects.

● Variations in molecular responses to nanoplastics are underscored among species.

● Recommendations are made to advance the multi-omics approach in nanoplastic research.

Amidst increasing concerns about plastic pollution’s impacts on ecology and health, nanoplastics are gaining global recognition as emerging environmental hazards. This review aimed to examine the complex molecular consequences and underlying fundamental toxicity mechanisms reported from the exposure of diverse aquatic organisms to nanoplastics. Through the comprehensive examination of transcriptomics, proteomics, and metabolomics studies, we explored the intricate toxicodynamics of nanoplastics in aquatic species. The review raised essential questions about the consistency of findings across different omics approaches, the value of combining these omics tools to understand better and predict ecotoxicity, and the potential differences in molecular responses between species. By amalgamating insights from 37 omics studies (transcriptome 22, proteome six, and metabolome nine) published from 2013 to 2023, the review uncovered both shared and distinct toxic effects and mechanisms in which nanoplastics can affect aquatic life, and recommendations were provided for advancing omics-based research on nanoplastic pollution. This comprehensive review illuminates the nuanced connections between nanoplastic exposure and aquatic ecosystems, offering crucial insights into the complex mechanisms that may drive toxicity in aquatic environments.

Keywords Ecotoxicity Transcriptomics Metabolomics Proteomics Plastic pollution Toxicity mechanisms

Corresponding Author(s): Elvis Genbo Xu

About author:

^#These authors contributed equally to this work.

Issue Date: 13 August 2024

Cite this article:

Mohamed Helal,Min Liu,Honghong Chen, et al. Multi-omics in nanoplastic research: a spotlight on aquatic life[J]. Front. Environ. Sci. Eng., 2024, 18(11): 133.

URL:

https://academic.hep.com.cn/fese/EN/10.1007/s11783-024-1893-3
https://academic.hep.com.cn/fese/EN/Y2024/V18/I11/133

Fig.1 Integrated multi-omics analysis of nanoplastic toxicity in different aquatic species. (A) Different omics studies on different aquatic species were analyzed for toxicity and mechanisms. A study gap was identified for important aquatic species such as aquatic mammals and coral reefs (question marks were labeled below each species). (B) Summary of the number of studies for each omics category. (C) Summarizes the most common toxicity mechanisms in different aquatic species. The studied species included both marine and freshwater origin (D), and fish were the most studied species among aquatic species (E).

Fig.2 Transcriptomic, proteomic, and metabolomic responses to aquatic nanoplastic exposure. Analysis of the transcriptome response of different aquatic species showed that oxidative stress, energy disruption, and metabolism disruption are the common toxicity mechanisms of nanoplastics. Dysregulated pathways span several cellular levels from DNA & RNA level (DNA transcription, translation, homologous recombination, DNA synthesis and repair, cell cycle progression, and apoptosis induction) to the cytoplasmic level of metabolic disruption of different cellular molecules (lipid, amino acid, purine and proline, carbon, etc.), to altered cellular signaling pathways such as MAPK signaling and cancer-related pathways up to system development level (defects in nervous, cardiac and reproductive systems). The proteomic response of different aquatic species to nanoplastics showed that oxidative stress, inhibition of photosynthesis, and metabolism dysregulation are the common toxicity mechanisms of nanoplastics. Dysregulated pathways involve genetic material defects, disruption of the metabolism of protein, carbohydrates, and lipids, and disruption of the ABC transporter system. Disrupted pathways are shown for representative species based on their proteomic analysis. The metabolomic response of different aquatic species showed that oxidative stress is a common phenomenon leading to tissue inflammation in adult zebrafish, algae, and microalgae. On the other hand, zebrafish larvae’ metabolome was disrupted in pathways related to cancer development upon nanoplastic exposure. Dysregulated pathways involve metabolism disruption of lipids, fatty acids, amino acids, purine-pyrimidine, and the TCA cycle.

Fig.3 Nanoplastic’s toxicity and mechanisms in zebrafish. Analysis of the transcriptomic, proteomic, and metabolomic response of zebrafish showed that oxidative stress, tissue inflammation, metabolic disruption of several cellular molecules, altered bile acid synthesis, and ABC transporter activity are common mechanisms in adult zebrafish exposed to nanoplastics. On the other hand, zebrafish larvae exposed to nanoplastic via different routes (e.g., injection and aqueous exposure) experience oxidative stress, lipid metabolism disruption and altered immune complement pathway, and defects in embryo development, cardiac, nervous, and reproductive development.

Fig.4 Omics technologies and perspectives in nanoplastic research. Analysis of nanoplastic toxicity mechanisms at the transcriptome (Illumina sequencing technology), proteome (HPLC coupled with tandem mass spectrometry and library identification), and metabolome level (HPLC or GC coupled with tandem mass spectrometry and library identification) can provide significant information on nanoplastic toxicity. Yet, there is a gap in integrating and linking the findings of all omics data into integrative connected findings. The application of advanced omics technology (spatial transcript, proteomics, and metabolomics) alongside artificial intelligence (AI) may enhance the detection of novel toxicity pathways and specific markers from the transcriptome to the metabolome level.

1	A L Andrady. (2011). Microplastics in the marine environment. Marine Pollution Bulletin, 62(8): 1596–1605 https://doi.org/10.1016/j.marpolbul.2011.05.030
2	A Arini, J Gigault, Z Venel, A Bertucci, M Baudrimont. (2022). The underestimated toxic effects of nanoplastics coming from marine sources: a demonstration on oysters (Isognomon alatus). Chemosphere, 295: 133824 https://doi.org/10.1016/j.chemosphere.2022.133824
3	B Aslam, M Basit, M A Nisar, M Khurshid, M H Rasool. (2017). Proteomics: technologies and their applications. Journal of Chromatographic Science, 55(2): 182–196 https://doi.org/10.1093/chromsci/bmw167
4	C Bedia. (2022). Metabolomics in environmental toxicology: applications and challenges. Trends in Environmental Analytical Chemistry, 34: e00161 https://doi.org/10.1016/j.teac.2022.e00161
5	N U Benson, O D Agboola, O H Fred-Ahmadu, G E de la Torre, A Oluwalana, A B Williams. (2022). Micro(nano)plastics prevalence, food web interactions, and toxicity assessment in aquatic organisms: a review. Frontiers in Marine Science, 9: 851281 https://doi.org/10.3389/fmars.2022.851281
6	J Bhagat, L Zang, N Nishimura, Y Shimada. (2020). Zebrafish: an emerging model to study microplastic and nanoplastic toxicity. Science of the Total Environment, 728: 138707 https://doi.org/10.1016/j.scitotenv.2020.138707
7	J Bhagat, L Zang, N Nishimura, Y Shimada. (2022). Application of omics approaches for assessing microplastic and nanoplastic toxicity in fish and seafood species. Trends in Analytical Chemistry, 154: 116674 https://doi.org/10.1016/j.trac.2022.116674
8	K Boyle, B Örmeci. (2020). Microplastics and nanoplastics in the freshwater and terrestrial environment: a review. Water, 12(9): 2633 https://doi.org/10.3390/w12092633
9	M A Browne, T S Galloway, R C Thompson. (2010). Spatial patterns of plastic debris along estuarine shorelines. Environmental Science & Technology, 44(9): 3404–3409 https://doi.org/10.1021/es903784e
10	H Cai, E G Xu, F Du, R Li, J Liu, H Shi. (2021). Analysis of environmental nanoplastics: progress and challenges. Chemical Engineering Journal, 410: 128208 https://doi.org/10.1016/j.cej.2020.128208
11	J Cao, Y Liao, W Yang, X Jiang, M Li. (2022). Enhanced microalgal toxicity due to polystyrene nanoplastics and cadmium co-exposure: From the perspective of physiological and metabolomic profiles. Journal of Hazardous Materials, 427: 127937 https://doi.org/10.1016/j.jhazmat.2021.127937
12	F Capanni, S Greco, N Tomasi, P G Giulianini, C Manfrin. (2021). Orally administered nano-polystyrene caused vitellogenin alteration and oxidative stress in the red swamp crayfish (Procambarus clarkii). Science of the Total Environment, 791: 147984 https://doi.org/10.1016/j.scitotenv.2021.147984
13	H Cheng, Y Dai, X Ruan, X Duan, C Zhang, L Li, F Huang, J Shan, K Liang, X Jia. et al.. (2022). Effects of nanoplastic exposure on the immunity and metabolism of red crayfish (Cherax quadricarinatus) based on high-throughput sequencing. Ecotoxicology and Environmental Safety, 245: 114114 https://doi.org/10.1016/j.ecoenv.2022.114114
14	T Y Choi, T I Choi, Y R Lee, S K Choe, C H Kim. (2021). Zebrafish as an animal model for biomedical research. Experimental & Molecular Medicine, 53(3): 310–317 https://doi.org/10.1038/s12276-021-00571-5
15	A Cincinelli, C Scopetani, D Chelazzi, E Lombardini, T Martellini, A Katsoyiannis, M C Fossi, S Corsolini. (2017). Microplastic in the surface waters of the Ross Sea (Antarctica): occurrence, distribution and characterization by FTIR. Chemosphere, 175: 391–400 https://doi.org/10.1016/j.chemosphere.2017.02.024
16	A Cózar, E Martí, C M Duarte, J García-De-Lomas, Sebille E Van, T J Ballatore, V M Eguíluz, J I González-Gordillo, M L Pedrotti, F Echevarría. et al.. (2017). The Arctic Ocean as a dead end for floating plastics in the North Atlantic branch of the Thermohaline circulation. Science Advances, 3(4): e1600582 https://doi.org/10.1126/sciadv.1600582
17	J P da Costa, P S M Santos, A C Duarte, T Rocha-Santos (2016). (Nano)plastics in the environment: sources, fates and effects. Science of the Total Environment, 566–567: 15–26
18	F Dang, Q Wang, Y Huang, Y Wang, B Xing. (2022). Key knowledge gaps for One Health approach to mitigate nanoplastic risks. Eco-Environment & Health, 1(1): 11–22 https://doi.org/10.1016/j.eehl.2022.02.001
19	C J Dedman, J A Christie-Oleza, V Fernández-Juárez, P Echeveste. (2022). Cell size matters: Nano- and micro-plastics preferentially drive declines of large marine phytoplankton due to co-aggregation. Journal of Hazardous Materials, 424: 127488 https://doi.org/10.1016/j.jhazmat.2021.127488
20	J G Derraik. (2002). The pollution of the marine environment by plastic debris: a review. Marine Pollution Bulletin, 44(9): 842–852 https://doi.org/10.1016/S0025-326X(02)00220-5
21	Z Duan, X Duan, S Zhao, X Wang, J Wang, Y Liu, Y Peng, Z Gong, L Wang. (2020). Barrier function of zebrafish embryonic chorions against microplastics and nanoplastics and its impact on embryo development. Journal of Hazardous Materials, 395: 122621 https://doi.org/10.1016/j.jhazmat.2020.122621
22	Z Duan, J Wang, H Zhang, Y Wang, Y Chen, J Cong, Z Gong, H Sun, L Wang. (2023). Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: a case study during zebrafish (Danio rerio) development. Journal of Hazardous Materials, 458: 131679 https://doi.org/10.1016/j.jhazmat.2023.131679
23	M C Eliso, E Bergami, L Bonciani, R Riccio, G Belli, M Belli, I Corsi, A Spagnuolo. (2023). Application of transcriptome profiling to inquire into the mechanism of nanoplastics toxicity during Ciona robusta embryogenesis. Environmental Pollution, 318: 120892 https://doi.org/10.1016/j.envpol.2022.120892
24	G Erni-Cassola, V Zadjelovic, M I Gibson, J A Christie-Oleza. (2019). Distribution of plastic polymer types in the marine environment: a meta-analysis. Journal of Hazardous Materials, 369: 691–698 https://doi.org/10.1016/j.jhazmat.2019.02.067
25	L J Feng, X D Sun, F P Zhu, Y Feng, J L Duan, F Xiao, X Y Li, Y Shi, Q Wang, J W Sun. et al.. (2020). Nanoplastics promote microcystin synthesis and release from cyanobacterial Microcystis aeruginosa. Environmental Science & Technology, 54(6): 3386–3394 https://doi.org/10.1021/acs.est.9b06085
26	C C Gaylarde, J A Baptista Neto, dE M a Fonseca (2021). Nanoplastics in aquatic systems: Are they more hazardous than microplastics? Environmental Pollution, 272: 115950
27	R Geyer, J R Jambeck, K L Law. (2017). Production, use, and fate of all plastics ever made. Science Advances, 3(7): e1700782 https://doi.org/10.1126/sciadv.1700782
28	J Gigault, A T Halle, M Baudrimont, P Y Pascal, F Gauffre, T L Phi, H El Hadri, B Grassl, S Reynaud (2018). Current opinion: What is a nanoplastic? Environmental Pollution, 235: 1030–1034
29	H Guo, L Wang, Y Deng, J Ye. (2021). Novel perspectives of environmental proteomics. Science of the Total Environment, 788: 147588 https://doi.org/10.1016/j.scitotenv.2021.147588
30	N B Hartmann, T Hüffer, R C Thompson, M Hassellöv, A Verschoor, A E Daugaard, S Rist, T Karlsson, N Brennholt, M Cole. et al.. (2019). Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris. Environmental Science & Technology, 53(3): 1039–1047 https://doi.org/10.1021/acs.est.8b05297
31	M Helal, N B Hartmann, F R Khan, E G Xu. (2023). Time to integrate “One Health Approach” into nanoplastic research. Eco-Environment & Health, 2(1): 18
32	J Hemmerich, G F Ecker. (2020). In silico toxicology: from structure-activity relationships towards deep learning and adverse outcome pathways. Wiley Interdisciplinary Reviews. Computational Molecular Science, 10(4): e1475 https://doi.org/10.1002/wcms.1475
33	A J Hill, H Teraoka, W Heideman, R E Peterson. (2005). Zebrafish as a model vertebrate for investigating chemical toxicity. Toxicological Sciences, 86(1): 6–19 https://doi.org/10.1093/toxsci/kfi110
34	J N Huang, B Wen, L Xu, H C Ma, X X Li, J Z Gao, Z Z Chen. (2022). Micro/nano-plastics cause neurobehavioral toxicity in discus fish (Symphysodon aequifasciatus): insight from brain-gut-microbiota axis. Journal of Hazardous Materials, 421: 126830 https://doi.org/10.1016/j.jhazmat.2021.126830
35	C B Jeong, H M Kang, E Byeon, M S Kim, S Y Ha, M Kim, J H Jung, J S Lee. (2021). Phenotypic and transcriptomic responses of the rotifer Brachionus koreanus by single and combined exposures to nano-sized microplastics and water-accommodated fractions of crude oil. Journal of Hazardous Materials, 416: 125703 https://doi.org/10.1016/j.jhazmat.2021.125703
36	Q Jiang, X Chen, H Jiang, M Wang, T Zhang, W Zhang. (2022). Effects of acute exposure to polystyrene nanoplastics on the channel catfish larvae: insights from energy metabolism and transcriptomic analysis. Frontiers in Physiology, 13: 923278 https://doi.org/10.3389/fphys.2022.923278
37	Q Jiang, W Zhang. (2021). Gradual effects of gradient concentrations of polystyrene nanoplastics on metabolic processes of the razor clams. Environmental Pollution, 287: 117631 https://doi.org/10.1016/j.envpol.2021.117631
38	E M F Kallenbach, N Friberg, A Lusher, D Jacobsen, R R Hurley. (2022). Anthropogenically impacted lake catchments in Denmark reveal low microplastic pollution. Environmental Science and Pollution Research International, 29(31): 47726–47739 https://doi.org/10.1007/s11356-022-19001-8
39	S Kishi, B E Slack, J Uchiyama, I V Zhdanova. (2009). Zebrafish as a genetic model in biological and behavioral gerontology. Where development meets aging in vertebrates: a mini-review. Gerontology, 55(4): 430–441 https://doi.org/10.1159/000228892
40	S J Klaine, P J J Alvarez, G E Batley, T F Fernandes, R D Handy, D Y Lyon, S Mahendra, M J Mclaughlin, J R Lead. (2008). Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environmental Toxicology and Chemistry, 27(9): 1825–1851 https://doi.org/10.1897/08-090.1
41	T Kögel, Ø Bjorøy, B Toto, A M Bienfait, M Sanden. (2020). Micro- and nanoplastic toxicity on aquatic life: determining factors. Science of the Total Environment, 709: 136050 https://doi.org/10.1016/j.scitotenv.2019.136050
42	A Kunz, F Schneider, N Anthony, H T Lin. (2023). Microplastics in rivers along an urban-rural gradient in an urban agglomeration: correlation with land use, potential sources and pathways. Environmental Pollution, 321: 121096 https://doi.org/10.1016/j.envpol.2023.121096
43	H Lai, X Liu, M Qu. (2022). Nanoplastics and human health: hazard identification and biointerface. Nanomaterials, 12(8): 1298 https://doi.org/10.3390/nano12081298
44	J L Lavers, A L Bond. (2017). Exceptional and rapid accumulation of anthropogenic debris on one of the world’s most remote and pristine islands. Proceedings of the National Academy of Sciences of the United States of America, 114(23): 6052–6055 https://doi.org/10.1073/pnas.1619818114
45	L Li, Y Xu, S Li, X Zhang, H Feng, Y Dai, J Zhao, T Yue. (2022). Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film. Journal of Hazardous Materials, 427: 127872 https://doi.org/10.1016/j.jhazmat.2021.127872
46	X Li, L Lu, S Ru, J Eom, D Wang, J Wang. (2023). Nanoplastics induce more severe multigenerational life-history trait changes and metabolic responses in marine rotifer Brachionus plicatilis: comparison with microplastics. Journal of Hazardous Materials, 449: 131070 https://doi.org/10.1016/j.jhazmat.2023.131070
47	X Liu, X Bao, X Wang, C Li, J Yang, Z Li. (2023a). Time-dependent immune injury induced by short-term exposure to nanoplastics in the Sepia esculenta larvae. Fish & Shellfish Immunology, 132: 108477 https://doi.org/10.1016/j.fsi.2022.108477
48	X Liu, J Ma, S Guo, Q Shi, J Tang. (2022). The combined effects of nanoplastics and dibutyl phthalate on Streptomyces coelicolor M145. Science of the Total Environment, 826: 154151 https://doi.org/10.1016/j.scitotenv.2022.154151
49	X Liu, J Ma, C Yang, L Wang, J Tang. (2021a). The toxicity effects of nano/microplastics on an antibiotic producing strain: Streptomyces coelicolor M145. Science of the Total Environment, 764: 142804 https://doi.org/10.1016/j.scitotenv.2020.142804
50	Y Liu, C Lorenz, A Vianello, K Syberg, A H Nielsen, T G Nielsen, J Vollertsen. (2023b). Exploration of occurrence and sources of microplastics (>10 μm) in Danish marine waters. Science of the Total Environment, 865: 161255 https://doi.org/10.1016/j.scitotenv.2022.161255
51	Z Liu, Y Li, E Pérez, Q Jiang, Q Chen, Y Jiao, Y Huang, Y Yang, Y Zhao. (2021b). Polystyrene nanoplastic induces oxidative stress, immune defense, and glycometabolism change in Daphnia pulex: application of transcriptome profiling in risk assessment of nanoplastics. Journal of Hazardous Materials, 402: 123778 https://doi.org/10.1016/j.jhazmat.2020.123778
52	Z Liu, Y Li, M S Sepúlveda, Q Jiang, Y Jiao, Q Chen, Y Huang, J Tian, Y Zhao. (2021c). Development of an adverse outcome pathway for nanoplastic toxicity in Daphnia pulex using proteomics. Science of the Total Environment, 766: 144249 https://doi.org/10.1016/j.scitotenv.2020.144249
53	T Matjašič, N Mori, I Hostnik, O Bajt, Viršek M Kovač. (2023). Microplastic pollution in small rivers along rural–urban gradients: variations across catchments and between water column and sediments. Science of the Total Environment, 858: 160043 https://doi.org/10.1016/j.scitotenv.2022.160043
54	S Matthews, L Mai, C B Jeong, J S Lee, E Y Zeng, E G Xu. (2021). Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups. Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP, 247: 109056 https://doi.org/10.1016/j.cbpc.2021.109056
55	K Mattsson, L A Hansson, T Cedervall. (2015). Nano-plastics in the aquatic environment. Environmental Science. Processes & Impacts, 17(10): 1712–1721 https://doi.org/10.1039/C5EM00227C
56	L J J Meijer, T Van Emmerik, R Van Der Ent, C Schmidt, L Lebreton. (2021). More than 1000 rivers account for 80% of global riverine plastic emissions into the ocean. Science Advances, 7(18): eaaz5803 https://doi.org/10.1126/sciadv.aaz5803
57	D Mennekes, B Nowack. (2023). Predicting microplastic masses in river networks with high spatial resolution at country level. Nature Water, 1(6): 523–533 https://doi.org/10.1038/s44221-023-00090-9
58	(2022) OECD. Global Plastics Outlook: Policy Scenarios to 2060. Paris: OECD Publishing
59	M Pang, Y Wang, Y Tang, J Dai, J Tong, G Jin. (2021). Transcriptome sequencing and metabolite analysis reveal the toxic effects of nanoplastics on tilapia after exposure to polystyrene. Environmental Pollution, 277: 116860 https://doi.org/10.1016/j.envpol.2021.116860
60	C Parenti, S Magni, A Ghilardi, G Caorsi, C Della Torre, L Del Giacco, A Binelli. (2021). Does triclosan adsorption on polystyrene nanoplastics modify the toxicity of single contaminants? Environmental Science. Nano, 8(1): 282–296 https://doi.org/10.1039/D0EN00961J
61	A F Pedersen, D N Meyer, A V Petriv, A L Soto, J N Shields, C Akemann, B B Baker, W L Tsou, Y Zhang, T R Baker (2020). Nanoplastics impact the zebrafish (Danio rerio) transcriptome: associated developmental and neurobehavioral consequences. Environmental Pollution, 266(Pt 2): 115090
62	P Qi, L Qiu, D Feng, Z Gu, B Guo, X Yan. (2023). Distinguish the toxic differentiations between acute exposure of micro- and nano-plastics on bivalves: an integrated study based on transcriptomic sequencing. Aquatic Toxicology, 254: 106367 https://doi.org/10.1016/j.aquatox.2022.106367
63	H Shin, C B Jeong. (2022). Metabolism deficiency and oxidative stress induced by plastic particles in the rotifer Brachionus plicatilis: common and distinct phenotypic and transcriptomic responses to nano- and microplastics. Marine Pollution Bulletin, 182: 113981 https://doi.org/10.1016/j.marpolbul.2022.113981
64	J R Snape, S J Maund, D B Pickford, T H Hutchinson. (2004). Ecotoxicogenomics: the challenge of integrating genomics into aquatic and terrestrial ecotoxicology. Aquatic Toxicology, 67(2): 143–154 https://doi.org/10.1016/j.aquatox.2003.11.011
65	E Sulukan, O Şenol, A Baran, M Kankaynar, S Yıldırım, T Kızıltan, İ Bolat, S B Ceyhun. (2022). Nano-sized polystyrene plastic particles affect many cancer-related biological processes even in the next generations; zebrafish modeling. Science of the Total Environment, 838: 156391 https://doi.org/10.1016/j.scitotenv.2022.156391
66	M Tamayo-Belda, A V Pérez-Olivares, G Pulido-Reyes, K Martin-Betancor, M González-Pleiter, F Leganés, D M Mitrano, R Rosal, F Fernández-Piñas. (2023). Tracking nanoplastics in freshwater microcosms and their impacts to aquatic organisms. Journal of Hazardous Materials, 445: 130625 https://doi.org/10.1016/j.jhazmat.2022.130625
67	M Tamayo-Belda, J J Vargas-Guerrero, K Martín-Betancor, G Pulido-Reyes, M González-Pleiter, F Leganés, R Rosal, F Fernández-Piñas. (2021). Understanding nanoplastic toxicity and their interaction with engineered cationic nanopolymers in microalgae by physiological and proteomic approaches. Environmental Science. Nano, 8(8): 2277–2296 https://doi.org/10.1039/D1EN00284H
68	M Teng, X Zhao, C Wang, C Wang, J C White, W Zhao, L Zhou, M Duan, F Wu. (2022). Polystyrene nanoplastics toxicity to zebrafish: dysregulation of the brain–intestine–microbiota axis. ACS Nano, 16(5): 8190–8204 https://doi.org/10.1021/acsnano.2c01872
69	A ter Halle, J F Ghiglione. (2021). Nanoplastics: a complex, polluting terra incognita. Environmental Science & Technology, 55(21): 14466–14469 https://doi.org/10.1021/acs.est.1c04142
70	L Tomanek. (2011). Environmental proteomics: changes in the proteome of marine organisms in response to environmental stress, pollutants, infection, symbiosis, and development. Annual Review of Marine Science, 3(1): 373–399 https://doi.org/10.1146/annurev-marine-120709-142729
71	M Torres-Ruiz, la Vieja A de, Alba Gonzalez M de, Lopez M Esteban, Calvo A Castaño, Portilla A I Cañas. (2021). Toxicity of nanoplastics for zebrafish embryos: what we know and where to go next. Science of the Total Environment, 797: 149125 https://doi.org/10.1016/j.scitotenv.2021.149125
72	R Trevisan, P Ranasinghe, N Jayasundara, R T Di Giulio. (2022). Nanoplastics in aquatic environments: impacts on aquatic species and interactions with environmental factors and pollutants. Toxics, 10(6): 326 https://doi.org/10.3390/toxics10060326
73	B Velten, O Stegle. (2023). Principles and challenges of modeling temporal and spatial omics data. Nature Methods, 20(10): 1462–1474 https://doi.org/10.1038/s41592-023-01992-y
74	W J Veneman, H P Spaink, N R Brun, T Bosker, M G Vijver. (2017). Pathway analysis of systemic transcriptome responses to injected polystyrene particles in zebrafish larvae. Aquatic Toxicology, 190: 112–120 https://doi.org/10.1016/j.aquatox.2017.06.014
75	L Wang, W M Wu, N S Bolan, D C W Tsang, Y Li, M Qin, D Hou. (2021). Environmental fate, toxicity and risk management strategies of nanoplastics in the environment: current status and future perspectives. Journal of Hazardous Materials, 401: 123415 https://doi.org/10.1016/j.jhazmat.2020.123415
76	Q Wang, W Liu, A Zeb, Y Lian, R Shi, J Li, Z Zheng. (2023). Toxicity effects of polystyrene nanoplastics and arsenite on Microcystis aeruginosa. Science of the Total Environment, 874: 162496 https://doi.org/10.1016/j.scitotenv.2023.162496
77	W Yang, P Gao, H Li, J Huang, Y Zhang, H Ding, W Zhang. (2021a). Mechanism of the inhibition and detoxification effects of the interaction between nanoplastics and microalgae Chlorella pyrenoidosa. Science of the Total Environment, 783: 146919 https://doi.org/10.1016/j.scitotenv.2021.146919
78	W Yang, P Gao, G Ma, J Huang, Y Wu, L Wan, H Ding, W Zhang. (2021b). Transcriptome analysis of the toxic mechanism of nanoplastics on growth, photosynthesis and oxidative stress of microalga Chlorella pyrenoidosa during chronic exposure. Environmental Pollution, 284: 117413 https://doi.org/10.1016/j.envpol.2021.117413
79	M Yao, L Mu, Z Gao, X Hu. (2023). Persistence of algal toxicity induced by polystyrene nanoplastics at environmentally relevant concentrations. Science of the Total Environment, 876: 162853 https://doi.org/10.1016/j.scitotenv.2023.162853
80	X You, X Cao, X Zhang, J Guo, W Sun. (2021). Unraveling individual and combined toxicity of nano/microplastics and ciprofloxacin to Synechocystis sp. at the cellular and molecular levels. Environment International, 157: 106842 https://doi.org/10.1016/j.envint.2021.106842
81	J Yu, L Chen, W Gu, S Liu, B Wu. (2022). Heterogeneity effects of nanoplastics and lead on zebrafish intestinal cells identified by single-cell sequencing. Chemosphere, 289: 133133 https://doi.org/10.1016/j.chemosphere.2021.133133
82	Z Yu, C Yan, D Qiu, X Zhang, C Wen, S Dong. (2023). Accumulation and ecotoxicological effects induced by combined exposure of different sized polyethylene microplastics and oxytetracycline in zebrafish. Environmental Pollution, 319: 120977 https://doi.org/10.1016/j.envpol.2022.120977
83	S Zeng, F Wu, M Chen, Y Li, M You, Y Zhang, P Yang, L Wei, X Z Ruan, L Zhao. et al.. (2022). Inhibition of fatty acid translocase (FAT/CD36) palmitoylation enhances hepatic fatty acid β-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1. Antioxidants & Redox Signaling, 36(16–18): 1081–1100 https://doi.org/10.1089/ars.2021.0157
84	H Zhang, H Cheng, Y Wang, Z Duan, W Cui, Y Shi, L Qin. (2022a). Influence of functional group modification on the toxicity of nanoplastics. Frontiers in Marine Science, 8: 800782 https://doi.org/10.3389/fmars.2021.800782
85	Y Zhang, X Li, J Liang, Y Luo, N Tang, S Ye, Z Zhu, W Xing, J Guo, H Zhang (2022b). Microcystis aeruginosa’s exposure to an antagonism of nanoplastics and MWCNTs: the disorders in cellular and metabolic processes. Chemosphere, 288(Pt 2): 132516
86	T Zhao, L Tan, X Han, X Wang, Y Zhang, X Ma, K Lin, R Wang, Z Ni, J Wang, J Wang. (2022). Microplastic-induced apoptosis and metabolism responses in marine Dinoflagellate, Karenia mikimotoi. Science of the Total Environment, 804: 150252 https://doi.org/10.1016/j.scitotenv.2021.150252

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