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Controlled release behaviors of chitosan/α, β- glycerophosphate thermo-sensitive hydrogels |
Wei-Fang LIU1, Chuan-Zhen KANG1, Ming KONG1, Yang LI1, Jing SU1, An YI2, Xiao-Jie CHENG1(), Xi-Guang CHEN1() |
1. College of Marine Life Science, Ocean University of China, Qingdao 266003, China; 2. The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266001, China |
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Abstract Chitosan/α, β-glycerophosphate (CS/α, β-GP) thermo-sensitive hydrogels presented flowable solution state at low temperature and semisolid hydrogel when the ambient temperature increased. In this research, different concentrations of metronidazole encapsulated, CS and α, β-GP, as well as different acid solvents, were chosen to evaluate their influences on the drug release behaviors from CS/α, β-GP hydrogels. It was found that there was a sustaining release during the first 3 h followed by a plateau. SEM images showed that drugs were located both on the surface and in the interior of hydrogels. The optimal preparation conditions of this hydrogel for drug release were as follows: 1.8% (w/v) CS in HAc solvent, 5.6% (w/v) α, β-GP and 5 g/L metronidazole encapsulation. Cytotoxicity evaluation found no toxic effect. In order to control the release rate, 2.5 g/L chitosan microspheres with spherical shape and smooth surface were incorporated, and it was found that the initial release process was alleviated, while drug concentration had no obvious effect on the release rate. It could be concluded that the metronidzole release behaviors could be optimized according to practical applications.
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Keywords
chitosan (CS)
glycerophosphate (GP)
thermo-sensitive hydrogel
controlled release
microsphere
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Corresponding Author(s):
CHENG Xiao-Jie,Email:xjcheng@ouc.edu.cn (X.J.C.); CHEN Xi-Guang,Email:xgchen@ouc.edu.cn (X.G.C.)
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Issue Date: 05 September 2012
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