Electrospun multifunctional tissue engineering scaffolds

doi:10.1007/s11706-014-0241-0

Front. Mater. Sci.

2014, Vol. 8

Issue (1) : 3-19 https://doi.org/10.1007/s11706-014-0241-0

REVIEW ARTICLE

Electrospun multifunctional tissue engineering scaffolds

Chong WANG, Min WANG(

)

Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China

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Abstract

Tissue engineering holds great promises in providing successful treatments of human body tissue loss that current methods are unable to treat or unable to achieve satisfactory clinical outcomes. In scaffold-based tissue engineering, a high-performance scaffold underpins the success of a tissue engineering strategy and a major direction in the field is to create multifunctional tissue engineering scaffolds for enhanced biological performance and for regenerating complex body tissues. Electrospinning can produce nanofibrous scaffolds that are highly desirable for tissue engineering. The enormous interest in electrospinning and electrospun fibrous structures by the science, engineering and medical communities has led to various developments of the electrospinning technology and wide investigations of electrospun products in many industries, including biomedical engineering, over the past two decades. It is now possible to create novel, multicomponent tissue engineering scaffolds with multiple functions. This article provides a concise review of recent advances in the R & D of electrospun multifunctional tissue engineering scaffolds. It also presents our philosophy and research in the designing and fabrication of electrospun multicomponent scaffolds with multiple functions.

Keywords electrospinning monocomponent multicomponent scaffold core--shell drug biomolecule growth factor controlled release

Corresponding Author(s): Min WANG

Issue Date: 24 June 2014

Cite this article:

Chong WANG,Min WANG. Electrospun multifunctional tissue engineering scaffolds[J]. Front. Mater. Sci., 2014, 8(1): 3-19.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-014-0241-0
https://academic.hep.com.cn/foms/EN/Y2014/V8/I1/3

Fig.1 Schematic diagram showing electrospinning: (a) basic setup for electrospinning; (b) electrospinning process.

Fig.2 Schematic diagram showing a setup for dual-source dual-power electrospinning (DSDP-ES).

Fig.3 Cross-sectional view of fibers in monocomponent multifunctional scaffolds loaded with drugs and/or biomolecules: (a) monolithic fibers loaded with two types of hydrophobic drugs; (b) core–shell structured fibers loaded with one type of hydrophilic drug and/or one type of biomolecules in the fiber core.

Tab.1 Electrospun monocomponent scaffolds with multiple functions

Fig.4 Schematic diagrams for multicomponent multifunctional scaffolds loaded with drugs and/or biomolecules: (a) a bicomponent scaffolds loaded with one type of hydrophilic drug and one type of biomolecules; (b) a multi-layered system for drugs and biomolecules.

Fig.5 Structure of multicomponent scaffolds made by MSMP-ES: (a) SEM micrographs of mono- and tricomponent scaffolds; (b) TEM micrograph of core–shell structured fibers loaded with rhVEGF.

Tab.2 Electrospun multicomponent scaffolds with multiple functions

Fig.6 In vitro release profiles of growth factors encapsulated in multicomponent scaffolds: (a) NGF and GDNF from bicomponent scaffolds; (b) rhVEGF and rhBMP-2 from tricomponent scaffolds.

Fig.7 Biological performance of tricomponent scaffolds loaded with rhVEGF, rhBMP-2 and Ca-P nanoparticles: (a) HUVEC migration; (b) ALP staining, showing osteogenic differentiation of hBMSCs; (c) mineralization by hBMSCs.

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