Corrosion resistance and antibacterial effects of hydroxyapatite coating induced by polyacrylic acid and gentamicin sulfate on magnesium alloy

doi:10.1007/s11706-019-0448-1

Front. Mater. Sci.

2019, Vol. 13

Issue (1) : 87-98 https://doi.org/10.1007/s11706-019-0448-1

RESEARCH ARTICLE

Corrosion resistance and antibacterial effects of hydroxyapatite coating induced by polyacrylic acid and gentamicin sulfate on magnesium alloy

Xiao-Jing JI¹, Qiang CHENG¹, Jing WANG¹, Yan-Bin ZHAO¹, Zhuang-Zhuang HAN¹, Fen ZHANG¹, Shuo-Qi LI¹(

), Rong-Chang ZENG¹(

), Zhen-Lin WANG²

¹. College of Materials Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, China
². College of Materials Science and Engineering, Chongqing University of Technology, Chongqing 400065, China

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Abstract

Magnesium (Mg) alloys have attracted considerable research attention as potential biocompatible implant materials. However, the major barriers to the extended use of such medical devices are the possibility of high corrosion rate and implant-associated infections. To solve them, a novel polyacrylic acid (PAA)/gentamicin sulfate (GS)-hydroxyapatite (HAp) coating was synthesized by a one-step hydrothermal deposition method. Characteristics of functional coatings were investigated by SEM, FTIR and XRD. Corrosion properties of samples were evaluated by electrochemical and hydrogen evolution tests. Antibacterial activities of the coatings against Staphylococcus aureus (S. aureus) were measured by the plate-counting method. Results showed that the as-prepared HAp coating with dense and flawless morphologies could not only enhance the corrosion resistance of Mg alloys, but also improve the adhesion strength between the HAp coating and the substrate. In addition, the induction of the apatite coating during immersion confirmed the excellent mineralization ability of the HAp coating. Moreover, the obtained HAp coating possessed antibacterial properties and could prolong the release of GS. Thus, the PAA/GS-HAp coated Mg alloy could serve as a better candidate for biomedical applications with good anti-corrosion and antibacterial properties.

Keywords magnesium alloy corrosion resistance antibacterial performance drug release hydroxyapatite coating

Corresponding Author(s): Shuo-Qi LI,Rong-Chang ZENG

Online First Date: 16 January 2019 Issue Date: 07 March 2019

Cite this article:

Xiao-Jing JI,Qiang CHENG,Jing WANG, et al. Corrosion resistance and antibacterial effects of hydroxyapatite coating induced by polyacrylic acid and gentamicin sulfate on magnesium alloy[J]. Front. Mater. Sci., 2019, 13(1): 87-98.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-019-0448-1
https://academic.hep.com.cn/foms/EN/Y2019/V13/I1/87

Tab.1 Chemical compositions of as-extruded AZ31 alloys

Fig.1 Schematic representation of the preparation of HAp/Mg, GS-HAp/Mg and PAA/GS-HAp/Mg.

Fig.2 SEM images of (a) pure HAp, (b) GS-HAp and (c) PAA/GS-HAp coatings. (d) Corresponding EDS spectra of all coatings.

Fig.3 Cross-sectional morphologies (upper) and corresponding line scan images (lower) of (a)(d) pure HAp, (b)(e) GS-HAp and (c)(f) PAA/GS-HAp coatings.

Fig.4 (a) FTIR spectra and (b) XRD patterns of pure HAp (i), GS-HAp (ii) and PAA/GS-HAp (iii) coatings.

Fig.5 Scratch results of pure HAp (a), GS-HAp (b) and PAA/GS-HAp (c) coatings.

Fig.6 (a) Polarization curves, (b) Nyquist plots and fitting curves, (c) Bode plots and (d) Bode plots of the phase angle versus frequency of the AZ31 substrate (i), HAp/Mg (ii), GS-HAp/Mg (iii) and PAA/GS-HAp/Mg (iv).

Fig.7 ? (a)(b) EEC?models and (c) R_ct of all samples in HBSS.

Fig.8 (a) HER results and (b) FTIR spectra of the AZ31 substrate (i), HAp/Mg (ii), GS-HAp/Mg (iii) and PAA/GS-HAp/Mg (iv) immersed in HBSS for 180 h.

Fig.9 SEM morphologies (upper) and corresponding EDS spectra (lower) of (a)(e) uncoated, (b)(f) pure HAp, (c)(g) GS-HAp and (d)(h) PAA/GS-HAp coated samples immersed in HBSS for 180 h.

Fig.10 Representative images and CFU numbers of viable bacteria growth of S. aureus colonies on different samples: control group (a), AZ31 substrate (b), HAp/Mg (c), GS-HAp/Mg (d) and PAA/GS-HAp/Mg (e) after culturing for 24 h.

Fig.11 (a) Cumulative GS release profiles and (b) total GS content and entrapment efficiency of GS-HAp (i) and PAA/GS-HAp (ii) coatings in PBS for 360 h.

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