Micro-patterned hydroxyapatite/silk fibroin coatings on Mg--Zn--Y--Nd--Zr alloys for better corrosion resistance and cell behavior guidance

doi:10.1007/s11706-020-0525-5

Front. Mater. Sci.

2020, Vol. 14

Issue (4) : 413-425 https://doi.org/10.1007/s11706-020-0525-5

RESEARCH ARTICLE

Micro-patterned hydroxyapatite/silk fibroin coatings on Mg--Zn--Y--Nd--Zr alloys for better corrosion resistance and cell behavior guidance

Lei CHANG^1,^2,³(

), Xiangrui LI^1,², Xuhui TANG¹, He ZHANG¹, Ding HE¹, Yujun WANG¹, Jiayin ZHAO¹, Jingan LI^1,^2,³, Jun WANG^1,^2,³, Shijie ZHU^1,^2,³, Liguo WANG^1,^2,³, Shaokang GUAN^1,^2,³(

)

¹. School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
². Henan Key Laboratory of Advanced Magnesium Alloy, Zhengzhou 450001, China
³. Key Laboratory of Materials Processing and Mold Technology (Ministry of Education), Zhengzhou University, Zhengzhou 450001, China

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Abstract

In this study, a micro-patterned hydroxyapatite/silk fibroin (HA-SF) coating was firstly fabricated on the surface of Mg–Zn–Y–Nd–Zr alloy by template-assisted electrospraying technique coupling with spin coating technique. Two types of micro-patterns were achieved with high contour accuracy, namely HA-SF(line-pattern) and HA-SF(dot-pattern). The microstructure, composition, surface wettability and corrosion behaviors of the coatings were investigated by SEM, EDS, FTIR, XRD, water contact angle and potentiodynamic polarization test. The results revealed the hydrophilic nature of coatings and two orders of magnitude reduction of corrosion density (i_corr) as compared with that of the substrate. All the micro-patterned surfaces promoted the attachment of MC3T3-E1 cells with visible filopodia after 1 d incubation. In addition, coatings with line pattern exhibited the superior guidance to cell migration as compared to dot pattern, and the preference of cell attachment in the convex zone was observed. In summary, the obtained micro-patterned HA-SF coatings possessed the remarkably improvement of anticorrosion ability and good efficacy in guidance of cell attachment and alignment, which can serve as a promising strategy for cellular response modulation at the interface of magnesium-based implants and bone.

Keywords magnesium alloy silk fibroin hydroxyapatite micro-patterned surface electrospraying technique

Corresponding Author(s): Lei CHANG,Shaokang GUAN

Online First Date: 25 September 2020 Issue Date: 09 December 2020

Cite this article:

Lei CHANG,Xiangrui LI,Xuhui TANG, et al. Micro-patterned hydroxyapatite/silk fibroin coatings on Mg--Zn--Y--Nd--Zr alloys for better corrosion resistance and cell behavior guidance[J]. Front. Mater. Sci., 2020, 14(4): 413-425.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-020-0525-5
https://academic.hep.com.cn/foms/EN/Y2020/V14/I4/413

Fig.1 Scheme of preparing micro-patterned HA-SF coatings on Mg–Zn–Y–Nd–Zr alloy.

Fig.2 Representative images of (a) stencil mask of micro-line pattern, (b) HA(line-pattern) coating, (c) HA-SF(line-pattern) coating, (d) Mg–Zn–Y–Nd–Zr, (e) stencil mask of micro-dot pattern, (f) HA(dot-pattern) coating, (g) HA-SF(dot-pattern) coating, and (h) HF-treated Mg alloy. (i)(j)(k)(l) Images of (b)(f)(c)(g) at high magnifications, respectively.

Tab.1 Chemical composition of specific zones in Fig. 2

Fig.3 (a) The cross-section morphology of HA-SF(line-pattern) coating and (b)(c)(d)(e) corresponding EDS mapping images of Mg, C, Ca and F.

Fig.4 (a) FTIR spectra of Mg–Zn–Y–Nd–Zr substrate, SF and HA-SF(line-pattern) coatings. (b) XRD patterns of Mg–Zn–Y–Nd–Zr substrate, HA and HA-SF(line-pattern) coatings.

Fig.5 Surface wettability of Mg–Zn–Y–Nd–Zr substrate, HF-treated Mg alloy, SF, HA-SF, HA-SF(dot-pattern) and HA-SF(line-pattern) coatings.

Fig.6 3D topography of surface: (a) Mg–Zn–Y–Nd–Zr; (b) HF-treated Mg alloy; (c) HA-SF(line-pattern) coating. (d) Top views of HA-SF(dot-pattern) coating and HA-SF(line-pattern) coating.

Fig.7 Electrochemical measurements of Mg–Zn–Y–Nd–Zr substrate, HF-treated Mg alloy, HA(line-pattern) and HA-SF(line-pattern) coatings: (a) Nyquist plots; (b) Bode plots; (c) polarization curves.

Tab.2 Corrosion potentials and current densities recorded in Fig. 7

Fig.8 Morphology and statistical analysis of MC3T3-E1 cells attached on various specimens in vitro: Fluorescence micrograph of cells cultured for 24 h on (a) Mg–Zn–Y–Nd–Zr, (b) HF-treated Mg alloy, (c) HA-SF(dot-pattern) and (d) HA-SF(line-pattern); Statistical analysis of (e) number of cell adhesion, (f) cell spreading area and (g) long axis of cell nucleus; Representative 3D reconstruction CLSM images of spatial growth and attachment sites of cells on (h) HA-SF(line-pattern) and (i) HA-SF(dot-pattern) coatings; Statistical analysis of (j) number of cell adhesion and (k) cell spreading area on the convex and concave zones of both HA-SF(dot-pattern) and HA-SF(line-pattern) coatings. _* represents a comparison with Mg–Zn–Y–Nd–Zr, and # represents that with other groups.

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