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Functionalization of PEG-PMPC-based polymers for potential theranostic applications |
Ning CHEN1,2, Sidi LI1,2, Xueping LI1,2, Lixia LONG1,2, Xubo YUAN1,2, Xin HOU1,2(), Jin ZHAO1,2() |
1. Tianjin Key Laboratory of Composite and Functional Materials, Tianjin 300350, China 2. School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China |
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Abstract The synergistic effect of polyethylene glycol (PEG) and poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) can effectively reduce the protein absorption, which is beneficial to theranostics. However, PEG–PMPC-based polymers have rarely been used as nanocarriers in the theranostic field due to their limited modifiability and weak interaction with other materials. Herein, a plain method was proposed to endow them with the probable ability of loading small active agents, and the relationship between the structure and the ability of loading hydrophobic agents was explored, thus expanding their applications. Firstly, mPEG–PMPC or 4-arm-PEG–PMPC polymer was synthesized by atom transfer radical polymerization (ATRP) using mPEG-Br or 4-arm-PEG-Br as the macroinitiator. Then a strong hydrophobic segment, poly(butyl methacrylate) (PBMA), was introduced and the ability to load small hydrophobic agents was further explored. The results showed that linear mPEG–PMPC–PBMA could form micelles 50–80 nm in size and load the hydrophobic agent such as Nile red efficiently. In contrast, star-like 4-arm-PEG–PMPC–PBMA, a monomolecular micelle (10–20 nm), could hardly load any hydrophobic agent. This work highlights effective strategies for engineering PEG–PMPC-based polymers and may facilitate the further application in numerous fields.
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Keywords
polyethylene glycol
poly(2-methacryloyloxyethyl phosphorylcholine)
atom transfer radical polymerization
self-assembly
monomolecular micelles
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Corresponding Author(s):
Xin HOU,Jin ZHAO
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Online First Date: 14 May 2021
Issue Date: 08 June 2021
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