Journal of Translational Neuroscience(转化神经科学电子杂志)
Cover Story   2020, Volume 5 Issue 1
   Online First

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, Volume 5 Issue 1

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Post-polio syndrome: a literature review
Qiaoyan Liu, Yuming Wang, Aimin Zhang
Journal of Translational Neuroscience. 2020, 5 (1): 1-7.

Abstract   PDF (7653KB)
Post-polio syndrome (PPS) is a neurologic disorder characterized by an accumulation of symptoms, most often muscle weakness, fatigue, and pain, decades after the initial polio. Diagnosis of PPS is based on the presence of a lower motor neuron disorder which is supported by neuro-physiological findings, as well as exclusion of other disorders as causes of new symptoms. The pathogenesis of PPS is still disputed. Rehabilitation for patients with PPS should take a comprehensive approach. Evaluation of the need for orthoses is often required.
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Nanotechnology-based therapeutics: new hope for ischemic cerebral stroke intervention
Sihan Wang, Qiming Gao, Fuyao Xiao, Yuming Zhao
Journal of Translational Neuroscience. 2020, 5 (1): 8-17.

Abstract   PDF (11773KB)
Ischemic cerebral stroke is a leading cause of death and disability globally. At present, thrombolytics, such as recombinant tissue-type plasminogen activator, are the only effective treatment for acute stroke. However, usage of thrombolytics has a strict therapeutic window and cannot be applied to a number of patients. Despite the promising effects of some neuroprotectants in preclinical studies, they failed in clinical trials as a result of poor pharmacokinetic properties, particularly with regard to solubility and permeability across the blood-brain barrier (BBB). Approaches for delivering these drugs by nanotechnologies may overcome these pharmacokinetic deficits and enhance their neuroprotective effects. However, issues such as potential side effects and biosafety properties currently limit clinical application of these approaches. In this article, we reviewed recent progress of nanotechnology-based interventions for stroke treatment, and in particular, summarized novel materials applied to synthesize nanocarriers, encapsulation with neuroprotectants, and factors impacting nanodrug bioactivities to provide a theoretical basis for the development of anti-stroke drugs.
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The progress in diagnosis and treatment of trigeminal neuralgia
Xiaodong Wang, Jian Yang, Suping Li, Maolin Ge, Rile Wu
Journal of Translational Neuroscience. 2020, 5 (1): 18-26.

Abstract   PDF (11351KB)
Trigeminal neuralgia (TN) is characterized by recurrent facial acupuncture like, electric shock like, burning like pain and other common clinical cranial nerve diseases in the trigeminal nerve distribution area. Around the world, people who are 40 or more are at risk. The incidence rate of TN of female is slightly higher than that of male and most of the affecting areas are on the right side unilaterally, which affects maxillary nerve and mandibular nerve, yet seldom ophthalmic nerve. Although controversy exists in the pathogenesis of TN, the most accepted theory is microvascular compression, which forces on the demyelination of the sensory axon of the trigeminal nerve root. Additionally, slight touch, conversation and chewing may cause intolerable pain. The diagnosis of TN mainly depends on clinical manifestation. The treatment mainly includes medicine, operation, and some supplementary methods. Among them, antiepileptics and tricyclic antidepressants are the first-line treatment. Surgical treatment is mainly used for patients with TN who have failed in drug treatment or have intolerable side effects. The methods of operation include destructive or non-destructive operation. Deep brain stimulation (DBS) and motor cortex stimulation (MCS) are new therapeutic techniques emerged recently. This method is expected to alleviate the refractory TN with poor drug control or ineffective conventional surgical treatment. At present,this method has not been approved for clinical treatment. Of course, more clinical data collection processes are in progress.
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Clinical features and literature review of Cogan’s syndrome with bilateral internal carotid artery occlusion
Yi Bao, Quanying Liu, Xiaoling Wang, Ying Wang, Miao Zhang, Juan Xuan, Guangjian Liu
Journal of Translational Neuroscience. 2020, 5 (1): 27-32.

Abstract   PDF (6508KB)
Cogan’s syndrome is rare. The purpose of this article is to describe a Cogan’s syndrome case characterized by bilateral internal carotid artery occlusion and to review the literature. Treatment remedies: we showed a patient with vertigo, nausea and retching, blurred vision, unclear speech. And the whole cerebral angiogram of the patient showed bilateral internal carotid artery occlusion without obvious neurological deficit. After differential diagnosis, compared with classic Cogan’s syndrome, granulomatous polyvasculitis (GPA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), the patient was considered as Cogan’s syndrome. Post treatment evaluating: the patient did not significantly improve vertigo after vascular bypass therapy. Conclusions: Cogan’s syndrome may cause severe vascular occlusion. The patient had no clinical symptoms; and the chronic occlusion caused by vascular inflammation may be the reason, so that there was enough time for compensation.
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4 articles