Design and fabrication of smart functional hydrogel wound dressing for diabetic foot ulcer

doi:10.1007/s11706-024-0691-y

Front. Mater. Sci.

2024, Vol. 18

Issue (3) : 240691 https://doi.org/10.1007/s11706-024-0691-y

Design and fabrication of smart functional hydrogel wound dressing for diabetic foot ulcer

Yufei Wang¹, Dandan Hou², Hui Zhao³(

), Xue Geng¹, Xin Wu⁴(

), Gaobiao Li⁴, Fei Sha⁴, Zengguo Feng¹, Zongjian Liu⁵(

), Lin Ye¹(

)

¹. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, China
². SINOPEC Beijing Research Institute of Chemical Industry, Beijing 100013, China
³. Department of Vascular Surgery, Beijing Luhe Hospital, Capital Medical University, Beijing 101100, China
⁴. Department of Vascular Surgery, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China
⁵. Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100044, China

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Abstract

Diabetic foot ulcer (DFU) often evolves into chronic wounds that resist healing over an extended period, sometimes necessitating amputation in severe cases. Traditional wound management approaches generally fail to control these chronic sores successfully. Thus, it arouses a huge demand in clinic for a novel wound dressing to treat DFU effectively. Hydrogel as an ideal delivery system exhibits excellent loading capacity and sustainable release behavior. It also boasts tunable physical and chemical properties adaptable to diverse biomedical scenarios, making it a suitable material for fabricating functional wound dressings to treat DFU. The hydrogel dressings are classified into hemostatic, antibacterial and anti-inflammatory, and healing-promoting hydrogel dressings by associating the pathogenesis of DFU in this paper. The design and fabrication strategies for the dressings, as well as their therapeutic effects in treating DFU, are extensively reviewed. Additionally, this paper highlights future perspectives of multifunctional hydrogel dressings in DFU treatment. This review aims to provide valuable references for material scientists to design and develop hydrogel wound dressings with enhanced capabilities for DFU treatment, and to further translate them into the clinic in the future.

Keywords hydrogel dressing multifunction design fabrication diabetic foot ulcer

Corresponding Author(s): Hui Zhao,Xin Wu,Zongjian Liu,Lin Ye

Issue Date: 06 August 2024

Cite this article:

Yufei Wang,Dandan Hou,Hui Zhao, et al. Design and fabrication of smart functional hydrogel wound dressing for diabetic foot ulcer[J]. Front. Mater. Sci., 2024, 18(3): 240691.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-024-0691-y
https://academic.hep.com.cn/foms/EN/Y2024/V18/I3/240691

Fig.1 Four processes of wound healing in patients with DFU (Created with BioRender).

Fig.2 Natural polysaccharides and drug molecules for the construction of multifunctional hydrogel dressings (Created with BioRender).

Fig.3 The preparation process and the principle of composite gelatin/CS/Ag. Reproduced with permission from Ref. [91].

Fig.4 Preparation of antibiotics conjugated dextran-PEG hydrogel and synthesis of antibiotics conjugated PEG. Reproduced with permission from Ref. [100].

Fig.5 Synthesis procedures of the G-PAGL hydrogel further applications in DFU dressing and schematic diagram of the antibacterial mechanism. Reproduced with permission from Ref. [104].

Fig.6 Schematic diagram of GelMA/SFMA/MSN-RES/PDEVs hydrogel preparation and application: (a) schematic of the modification of the gelatin molecule with MA; (b) schematic modification of a silk fibroin molecule with GMA; (c) schematic showing the preparation of GelMA/SFMA/MSN-RES/PDEVs hydrogels used as a dressing for wounds in a diabetic mouse model. Reproduced with permission from Ref. [114].

Fig.7 Schematic diagram of the preparation of glucose-responsive metal–organic hydrogel and its mechanism of repairing diabetic skin wounds. Reproduced with permission from Ref. [123].

Fig.8 (a) Schematic diagram of the preparation of multifunctional hydrogel. (b) Schematic diagram of intelligent wound monitoring with multifunctional hydrogel as wound dressing, including wound recognition, real-time status monitoring, and personalized wound management. Reproduced with permission from Ref. [125].

Fig.9 The method of fabricating and processing hydrogel dressings for DFU (created with BioRender).

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