Research progress of endogenous neural stem cells in injury repair strategies after ischemic stroke

doi:10.3868/j.issn.2096-0689.2024.02.001

Journal of Translational Neuroscience

2024, Vol. 9

Issue (2) : 1-8 https://doi.org/10.3868/j.issn.2096-0689.2024.02.001

Review

Research progress of endogenous neural stem cells in injury repair strategies after ischemic stroke

Lu Yang¹, Changhong Ren^2,3, Wenbo Zhao^1,2, Xunming Ji^2,3,4*

1.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2.Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100053, China
3.Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
4.Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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Abstract Ischemic stroke is characterized by high incidence, high mortality, and high disability and is the primary cause of death and disability among adults in China. Endogenous neural stem cells (NSCs) are a group of cells that have the potential to self-renew and differentiate into functional nerve cells. Under normal circumstances, NSCs are in a quiet state. When the body is subjected to specific stimulation or injury, NSCs can be activated, proliferate, migrate to the damaged site, and differentiate into functional nerve cells to repair the injured tissue. NSCs induced by ischemic stimulation have limited regenerative capacity and cannot completely restore damaged tissues. Exogenous NSC transplantation has some effect. However, it is limited by the low survival rate of transplanted NSCs, immune rejection, ethics, and risk of tumor formation. Therefore, it is necessary to study fur- ther the strategies and mechanisms of endogenous NSC activation to promote nerve function repair after stroke. This article reviews recent advancements in drug therapy, hypoxic/ischemic conditioning, Chinese medicine, and rehabilitation strategies for NSC treatment. Furthermore, it explores new strategies and mechanisms developed recently, offering innovative plans and ideas to enhance clinical stroke treatment.

Keywords ischemic stroke neuroprotection neural stem cell neurogenesis

Issue Date: 25 June 2024

Cite this article:

Lu Yang, Changhong Ren, Wenbo Zhao, Xunming Ji. Research progress of endogenous neural stem cells in injury repair strategies after ischemic stroke[J]. Journal of Translational Neuroscience,2024, 9(2): 1-8.

URL:

https://academic.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2024.02.001
https://academic.hep.com.cn/jtn/EN/Y2024/V9/I2/1

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