Multifaceted functions of Siva-1: more than an Indian God of Destruction

doi:10.1007/s13238-012-2018-5

Prot Cell

2012, Vol. 3

Issue (2) : 117-122 https://doi.org/10.1007/s13238-012-2018-5 PMID: 22426980

MINI-REVIEW

Multifaceted functions of Siva-1: more than an Indian God of Destruction

Yide Mei(

), Mian Wu(

)

Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China

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Abstract

Siva-1, as a p53-inducible gene, has been shown to induce extensive apoptosis in a number of different cell lines. Recent evidence suggests that Siva-1 functions as a part of the auto-regulatory feedback loop that restrains p53 through facilitating Mdm2-mediated p53 degradation. Also, Siva-1 plays an important role in suppressing tumor metastasis. Here we review the current understanding of Siva-1-mediated apoptotic signaling pathway. We also add comments on the p53-Siva-1 feedback loop, the novel function of Siva-1 in suppressing tumor metastasis, and their potential implications.

Keywords Siva-1 p53 apoptosis tumor metastasis stathmin

Corresponding Author(s): Mei Yide,Email:meiyide@ustc.edu.cn; Wu Mian,Email:wumian@ustc.edu.cn

Issue Date: 01 February 2012

Cite this article:

Yide Mei,Mian Wu. Multifaceted functions of Siva-1: more than an Indian God of Destruction[J]. Prot Cell, 2012, 3(2): 117-122.

URL:

https://academic.hep.com.cn/pac/EN/10.1007/s13238-012-2018-5
https://academic.hep.com.cn/pac/EN/Y2012/V3/I2/117

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