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Recent advances in molecular machines based on toehold-mediated strand displacement reaction |
Yijun Guo1,Bing Wei1,2,Shiyan Xiao1,Dongbao Yao1,Hui Li1,Huaguo Xu3,Tingjie Song1,Xiang Li1,Haojun Liang1,2( ) |
1. CAS Key Laboratory of Soft Matter Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China
2. Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China
3. College of Materials and Textile Engineering institute, Jiaxing University, Jiaxing 314000, China |
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Abstract Background: The DNA strand displacement reaction, which uses flexible and programmable DNA molecules as reaction components, is the basis of dynamic DNA nanotechnology, and has been widely used in the design of complex autonomous behaviors.
Results: In this review, we first briefly introduce the concept of toehold-mediated strand displacement reaction and its kinetics regulation in pure solution. Thereafter, we review the recent progresses in DNA complex circuit, the assembly of AuNPs driven by DNA molecular machines, and the detection of single nucleotide polymorphism (SNP) using DNA toehold exchange probes in pure solution and in interface state. Lastly, the applications of toehold-mediated strand displacement in the genetic regulation and silencing through combining gene circuit with RNA interference systems are reviewed.
Conclusions: The toehold-mediated strand displacement reaction makes DNA an excellent material for the fabrication of molecular machines and complex circuit, and may potentially be used in the disease diagnosis and the regulation of gene silencing in the near future.
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Author Summary The controllable kinetics of strand displacement reaction, along with the programmability of DNA sequence, make DNA an excellent material for the fabrication of molecular machines and complex circuit, and may potentially be used in the disease diagnosis. In this review, we discuss the applications of toehold-mediated strand displacement in the constructions of exquisite molecular devices, complex functional circuits and reaction networks, and biomedical applications such as SNP discrimination and gene-induced disease detection and gene regulation. |
Keywords
toehold-mediated strand displacement
DNA molecular machines
SNP
gene expression regulation
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Fund: |
Corresponding Author(s):
Haojun Liang
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Just Accepted Date: 22 January 2017
Issue Date: 22 March 2017
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