Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

doi:10.1007/s11705-012-1299-9

Front Chem Sci Eng

2012, Vol. 6

Issue (3) : 246-252 https://doi.org/10.1007/s11705-012-1299-9

RESEARCH ARTICLE

Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery

Xiaojing ZHANG^1,2, Weixin ZHANG^1,2(

), Zeheng YANG^1,2, Zhao ZHANG^1,2

1. School of Chemical Engineering, Hefei University of Technology, Hefei 230009, China; 2. Anhui Key Laboratory of Controllable Chemical Reaction & Material Chemical Engineering, Hefei 230009, China

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Abstract

A solvothermal method has been successfully used to prepare nanostructured hydroxyapatite (HA) hollow spheres with average diameters of about 500 nm and shell thicknesses of about 100 nm in a glycerin/water mixed solvent. Transmission electron microscopy (TEM) and field-emission scanning electron microscopy (FESEM) images show that the shells of the HA hollow spheres are actually composed of nanosheets with thicknesses of about 10 nm. By tuning the glycerin/water volume ratio, two other kinds of HA solid spheres with average diameters of about 6 or 20 μm were assembled from nanoflakes. The properties of the different kinds of spheres as drug delivery carriers were evaluated. Ibuprofen (IBU) was chosen as the model drug to load into the HA samples. The nanostructured HA samples showed a slow and sustained release of IBU. The HA hollow spheres exhibited a higher drug loading capacity and more favorable release properties than the HA solid spheres and thus are very promising for controlled drug release applications.

Keywords hydroxyapatite hollow spheres synthesis drug release

Corresponding Author(s): ZHANG Weixin,Email:wxzhang@hfut.edu.cn

Issue Date: 05 September 2012

Cite this article:

Xiaojing ZHANG,Weixin ZHANG,Zeheng YANG, et al. Nanostructured hollow spheres of hydroxyapatite: preparation and potential application in drug delivery[J]. Front Chem Sci Eng, 2012, 6(3): 246-252.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-012-1299-9
https://academic.hep.com.cn/fcse/EN/Y2012/V6/I3/246

Fig.1 XRD patterns of nanostructured HA samples prepared at different glycerin/water ratios: (a) 36∶ 4, (b) 20∶ 20, and (c) 0∶ 40

Fig.2 FESEM and TEM images of nanostructured HA samples prepared at different glycerin/water ratios: (a, b, c) 36∶ 4, (d, e, f) 20∶ 20 and (g, h, i) 0∶ 40

Fig.3 IBU release curves of drug-loaded HA samples prepared at different glycerin/water ratios and different drug loading concentrations in SBF: (a) 36∶ 4, 50 mg/mL, (b) 20∶ 20, 50 mg/mL, (c) 0∶ 40, 50 mg/mL, (d) 36∶ 4, 20 mg/mL, (e) 20∶ 20, 20 mg/mL and (f) 0∶ 40, 20 mg/mL

Fig.4 FTIR spectra of the samples: (a) IBU, (b) HA sample prepared at a glycerin/water ratio of 36∶ 4 (sample 1) and (c) HA sample prepared at a glycerin/water ratio of 36∶ 4 (sample 1) loaded with a drug concentration of 50 mg/mL

Fig.5 Nitrogen adsorption-desorption isotherms of nanostructured HA samples prepared at different glycerin/water ratios: (a) 36∶ 4 (sample 1), (b) 0∶ 40 (sample 3)

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