ROS-mediated regulation of CXCR4 in cancer

doi:10.1007/s11515-012-1204-4

Front Biol

2013, Vol. 8

Issue (3) : 273-278 https://doi.org/10.1007/s11515-012-1204-4

REVIEW

ROS-mediated regulation of CXCR4 in cancer

Mahandranauth A. CHETRAM, Cimona V. HINTON(

)

Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA

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Abstract

Oxidative stress and the accumulation of reactive oxygen specie (ROS) play a role in cancer cells developing an advanced, phenotypic signature that associates with metastasis and progression. Increased ROS concentrations are involved in promoting cancer development and metastasis by inducing expression of oncogenes, suppressing activity of anti-survival molecules and by activating various cell survival and proliferation signaling pathways. Oxidative stress is higher in the epithelium of cancer patients than patients without the disease, and antioxidant trials are currently being explored as a therapeutic option. However, studies have shown that ROS increases expression of CXCR4 in cancer and immune cells. CXCR4 expression in tumors strongly correlates to metastasis and poor prognosis. Herein, we discuss an emerging relationship between ROS and CXCR4 in cancer cells.

Keywords reactive oxygen species CXCR4 HIF1α metastasis PI3K/AKT ERK1/2

Corresponding Author(s): HINTON Cimona V.,Email:chinton@cau.edu

Issue Date: 01 June 2013

Cite this article:

Mahandranauth A. CHETRAM,Cimona V. HINTON. ROS-mediated regulation of CXCR4 in cancer[J]. Front Biol, 2013, 8(3): 273-278.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-012-1204-4
https://academic.hep.com.cn/fib/EN/Y2013/V8/I3/273

Fig.1 A schematic of ROS-mediated regulation of CXCR4 expression in cancer cells as described by (1) Chetram et al. (), (2) Lui et al. (2006) and (3) Staller et al. ().

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