Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: A review

doi:10.1007/s11706-021-0568-2

Front. Mater. Sci.

2021, Vol. 15

Issue (3) : 374-390 https://doi.org/10.1007/s11706-021-0568-2

REVIEW ARTICLE

Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: A review

Qingni XU, Chaohua LI, Yuqi CHEN, Yueli ZHANG, Bo LU(

)

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China

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Abstract

The design and development of multifunctional nano-drug delivery systems (NDDSs) is a solution that is expected to solve some intractable problems in traditional cancer treatment. In particular, metal-organic frameworks (MOFs) are novel hybrid porous nanomaterials which are constructed by the coordination of metal cations or clusters and organic bridging ligands. Benefiting from their intrinsic superior properties, MOFs have captivated intensive attentions in drug release and cancer theranostic. Based on what has been achieved about MOF-based DDSs in recent years, this review introduces different stimuli-responsive mechanisms of them and their applications in cancer diagnosis and treatment systematically. Moreover, the existing challenges and future opportunities in this field are summarized. By realizing industrial production and paying attention to biosafety, their clinical applications will be enriched.

Keywords metal-organic framework nanomaterial stimuli-responsiveness cancer theranostic

Corresponding Author(s): Bo LU

Online First Date: 07 September 2021 Issue Date: 24 September 2021

Cite this article:

Qingni XU,Chaohua LI,Yuqi CHEN, et al. Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: A review[J]. Front. Mater. Sci., 2021, 15(3): 374-390.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-021-0568-2
https://academic.hep.com.cn/foms/EN/Y2021/V15/I3/374

Fig.1 Schematic illustration for the formation and drug release mechanism of the HA/α-TOS@ZIF-8 nanoplatform. Reproduced with permission from Ref. [42].

Fig.2 Schematic illustration of the preparation of CCM@MOF-M(DTBA), and the redox-responsive degradation of CCM@MOF-M(DTBA) in tumor cells for cancer therapy. Reproduced with permission from Ref. [64].

Fig.3 Schematic illustration of SQU@PCN preparation and the tumor cell death process by homeostatic perturbation therapy and sensitized photodynamic therapy. Reproduced with permission from Ref. [70].

Fig.4 Schematic illustration for the formation and drug release mechanism of UCNPs@MIL-100(Fe) NPs. Reproduced with permission from Ref. [80].

Fig.5 (a) Scheme of the synthesis process for DHMS. (b) The proposed mechanism of ROS generation by DHMS under ultrasound irradiation. Reproduced with permission from Ref. [88].

Fig.6 Schematic illustration of the design and application of novel porous Fe₃O₄@C–PVP@DOX nanocomposites as smart platforms for the combined cancer therapy. Reproduced with permission from Ref. [91].

Fig.7 Schematic illustration of the preparation of NMIL-100@GOx@C and the cascade processes for cancer therapy. Reproduced with permission from Ref. [106].

Fig.8 (a) Synthesis of MnO_x/UiO-66-F/PPEG NPs and ¹H/¹⁹F dual-mode imaging of MnO_x/UiO-66-F/PPEG NPs in vivo. (b) The representative ¹H MRI, ¹⁹F MRI, and the merge of ¹H MRI and ¹⁹F MRI under a 7 T magnetic field at different time (0, 30 and 90 min, respectively) in tumor and subcutaneous tissue with a dose of 249.4 mg·kg⁻¹ body weight. Reproduced with permission from Ref. [118].

Fig.9 (a) Schematic illustration of the design and application of DOX/Pd@ZIF-8@PDA NPs. (b) PA imaging of DOX/Pd@ZIF-8@PDA NPs in tumor site. Reproduced with permission from Ref. [120].

Fig.10 (a) Schematic illustration of an endocytosis Mn³⁺-sealed MOF nanosystem for MRI- and OI-guided PDT by controlled ROS generation and GSH depletion after being unlocked by overexpressed GSH in tumor cells. (b) Fluorescence and (c) T₁ contrast signals in tumor sites by intratumoral injection within 30 min. (d) In vivo MRI signal after intravenous injection with MOFs. (e) FI of mice over time by intravenous injection and tissue imaging at 36 h postinjection [122]. (f) Schematic illustration of the fabrication process of FDGI NPs. (g) Schematic illustration of FDGI theranostic nanoplatform for MR/PA/PT imaging-guided chemotherapy, PTT and PDT compound antitumor therapy [123]. Reproduced with permission from Refs. [122–123].

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