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The network of cytokines, receptors and transcription factors governing the development of dendritic cell subsets |
Priyanka Sathe1,2( ), Li Wu1,3() |
| 1. Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia; 2. Department of Medical Biology, University of Melbourne, Australia; 3. Tsinghua University School of Medicine, Beijing 100084, China |
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Abstract The pathways leading to the development of different dendritic cell (DC) subsets have long been unclear. In recent years, a number of precursors on the route to DC development, both under steady state and inflammatory conditions, have been described, and the nature of these pathways is becoming clearer. In addition, the development of various knockout mouse models and an in vitro system modelling DC development have revealed the role of numerous cytokines and transcription factors that influence DC development. Here, we review recent findings on the factors important in DC development in the context of the developmental pathways that have been described.
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| Keywords
dendritic cell
cytokines
receptors
transcription factors
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Corresponding Author(s):
Sathe Priyanka,Email:sathe@wehi.edu.au (P. Sathe); Wu Li,Email:wuli@tsinghua.edu.cn (L. Wu)
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Issue Date: 01 August 2011
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