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Protein Cell    2014, Vol. 5 Issue (7) : 503-517    https://doi.org/10.1007/s13238-014-0058-8
REVIEW
The regulation of TGF-β/SMAD signaling by protein deubiquitination
Juan Zhang1,2,Xiaofei Zhang2,Feng Xie1,Zhengkui Zhang1,Hans van Dam2,Long Zhang1,2,*(),Fangfang Zhou2,*()
1. Life Sciences Institute, Zhejiang University, Hangzhou 310058, China
2. Department of Molecular Cell Biology, Cancer Genomics Centre Netherlands and Centre of Biomedical Genetics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands
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Abstract

Transforming growth factor-β (TGF-β) members are key cytokines that control embryogenesis and tissue homeostasis via transmembrane TGF-β type II (TβR II) and type I (TβRI) and serine/threonine kinases receptors. Aberrant activation of TGF-β signaling leads to diseases, including cancer. In advanced cancer, the TGF-β/SMAD pathway can act as an oncogenic factor driving tumor cell invasion and metastasis, and thus is considered to be a therapeutic target. The activity of TGF-β/SMAD pathway is known to be regulated by ubiquitination at multiple levels. As ubiquitination is reversible, emerging studies have uncovered key roles for ubiquitin-removals on TGF-β signaling components by deubiquitinating enzymes (DUBs). In this paper, we summarize the latest findings on the DUBs that control the activity of the TGF-β signaling pathway. The regulatory roles of these DUBs as a driving force for cancer progression as well as their underlying working mechanisms are also discussed.
Keywords TGF-β      TβRI      SMAD      DUB      ubiquitin      deubiquitination     
Corresponding Author(s): Long Zhang   
Issue Date: 31 July 2014
 Cite this article:   
Juan Zhang,Xiaofei Zhang,Feng Xie, et al. The regulation of TGF-β/SMAD signaling by protein deubiquitination[J]. Protein Cell, 2014, 5(7): 503-517.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-014-0058-8
https://academic.hep.com.cn/pac/EN/Y2014/V5/I7/503
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