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Protein Cell    2016, Vol. 7 Issue (8) : 548-561    https://doi.org/10.1007/s13238-016-0288-z
REVIEW
Regulation of TAZ in cancer
Xin Zhou1,2(),Qun-Ying Lei1()
1. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Department of Biochemistry and Molecular Biology and Institutes of Biomedical Sciences, Fudan University Shanghai Medical College, Shanghai 200032, China
2. Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
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Abstract

TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and-independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled receptors (GPCRs), cellular energy status, hypoxia and osmotic stress. Besides its role in normal tissue development, TAZplays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness in multiple human cancers. We discuss here the regulators and regulation of TAZ. We also highlight the tumorigenic roles of TAZ and its potential therapeutic impact in human cancers.
Keywords TAZ      the Hippo pathway      cancer     
Corresponding Author(s): Xin Zhou,Qun-Ying Lei   
Issue Date: 12 September 2016
 Cite this article:   
Xin Zhou,Qun-Ying Lei. Regulation of TAZ in cancer[J]. Protein Cell, 2016, 7(8): 548-561.
 URL:  
https://academic.hep.com.cn/pac/EN/10.1007/s13238-016-0288-z
https://academic.hep.com.cn/pac/EN/Y2016/V7/I8/548
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