Please wait a minute...
Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front. Med.    2020, Vol. 14 Issue (5) : 681-688    https://doi.org/10.1007/s11684-020-0801-x
COMMENTARY
The role played by traditional Chinese medicine in preventing and treating COVID-19 in China
Qingwei Li1, Han Wang1,2, Xiuyang Li1, Yujiao Zheng1,3, Yu Wei1,3, Pei Zhang1, Qiyou Ding1,3, Jiaran Lin1,4, Shuang Tang1,4, Yikun Zhao5, Linhua Zhao1(), Xiaolin Tong1()
1. Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100056, China
2. Academic Inheritance Workstation of Academician Tong Xiaolin of Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine, Shenzhen 518034, China
3. Beijing University of Chinese Medicine, Beijing 100019, China
4. Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
5. Gansu University of Chinese Medicine, Lanzhou 730000, China
 Download: PDF(120 KB)   HTML
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract

Traditional Chinese medicine (TCM), an ancient system of alternative medicine, played an active role in the prevention and control of COVID-19 in China. It improved the clinical symptoms of patients, reduced the mortality rate, improved the recovery rate, and effectively relieved the operating pressure on the national medical system during critical conditions. In light of the current global pandemic, TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions. Here, we summarize the TCM-related measures that were widely used in China, including TCM guidelines, the Wuchang pattern, mobile cabin hospitals, integrated treatment of TCM and modern medicine for critical patients, and non-medicine therapy for convalescent patients, and describe how TCM effectively treated patients afflicted with the COVID-19. Effective TCM therapies could, therefore, be recommended and practiced based on the existing medical evidence from increased scientific studies.

Keywords traditional Chinese medicine      COVID-19      Wuchang pattern      mobile cabin hospital      convalescent patients      three formulae and three medicines     
Corresponding Author(s): Linhua Zhao,Xiaolin Tong   
Just Accepted Date: 09 June 2020   Online First Date: 10 July 2020    Issue Date: 12 October 2020
 Cite this article:   
Qingwei Li,Han Wang,Xiuyang Li, et al. The role played by traditional Chinese medicine in preventing and treating COVID-19 in China[J]. Front. Med., 2020, 14(5): 681-688.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-020-0801-x
https://academic.hep.com.cn/fmd/EN/Y2020/V14/I5/681
1 World Health Organization. Coronavirus disease (COVID-19) situation report–128. 2020.
2 National Health Commission of the People’s Republic of China. The latest situation of the COVID-19 situation as of 24:00 on March 29. 2020. (in Chinese)
3 People’s Daily. “Three formulas and three medicines” selected as COVID-19 treatment and over 90% of patients were applied to the TCM treatment. 2020.(in Chinese)
4 World Health Organization. ICD-11: Classifying disease to map the way we live and die. 2018.
5 Z Wu, JM McGoogan. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323(13): 1239
https://doi.org/10.1001/jama.2020.2648 pmid: 32091533
6 P Song, L Zhao, X Li, J Su, Z Jiang, B Song, W Liu, S Tang, Y Lei, Q Ding, Z Yang, J Lin, Y Wei, X Tong. Interpretation of TCM part in Diagnosis and Treatment Protocol for COVID-19 (Trial Version 7). J Tradit Chin Med 2020; [Epub ahead of print]
7 National Administration of Traditional Chinese Medicine. Xiaolin Tong: “Wuchang pattern” with Chinese medicine characteristics provided new ideas for community prevention and control of COVID-19. 2020. (in Chinese)
8 BL Zhang. What role has traditional Chinese medicine played in the prevention and treatment of COVID-19. Study Times (Xue Xi Shi Bao) 2020-3-18. 6 (in Chinese)
9 H Wang. Analysis of curative effect of Reduning injection on children with lobar pneumonia. Heilongjiang Med Pharm (Heilongjiang Yi Yao Ke Xue) 2019; 42(3): 131–132 (in Chinese)
10 F Bai, D Xu, S Jiang. 40 cases of adult bronchopneumonia treated by Reduning injection. West J Tradit Chin Med (Xi Bu Zhong Yi Yao) 2019; 32(2): 98–100 (in Chinese)
11 Q Yin, JX Zhang, TH Yu, SM Li. Clinical effect of ribavirin injection combined with Tanreqing ultrasonic atomization in treating viral pneumonia caused by influenza virus infection. Chin J Clin Rational Drug Use (Lin Chuang He Li Yong Yao Za Zhi) 2016; 9(12): 10–11,14 (in Chinese)
12 RZ Yuan, H Wang, WH Han, MC Ma, XL Yang. Effect of Tanreqing injection on CRP, PCT, WBC and cellular immune indexes in severe pneumonia. Chin J Diff Cases (Yi Nan Bing Za Zhi) 2016; 15(2): 147–149,153 (in Chinese)
13 S Zhao, Y Liu, F Fan, X Wang, Z Jin, W Wang, XC Da Li. Traditional Chinese medicine treatment strategy for convalescent patients with severe or critical cases of COVID-19. J Hunan Univ Chin Med (Hunan Zhong Yi Yao Da Xue Xue Bao) 2020; 40(4): 387–391 (in Chinese)
14 L Lan, D Xu, G Ye, C Xia, S Wang, Y Li, H Xu. Positive RT-PCR test results in patients recovered from COVID-19. JAMA 2020; 323(15): 1502
https://doi.org/10.1001/jama.2020.2783 pmid: 32105304
15 XD Li, BY Liu, Y Wang, L Guan, GX Li, H, Wang J Wang, CS Weng, MZ Xiao, XL Tong . Interpretation of Recommendation on the Rehabilitation Guidance of Traditional Chinese Medicine for Coronavirus Disease in the Recovery Period (Trial). J Tradit Chin Med (Zhong Yi Za Zhi) 2020; 61(11): 928–934 (in Chinese)
16 Wang JP. TCM anti-epidemic 27: Tong Xiaolin team announced three new research results on COVID-19. 2020. (in Chinese)
17 K Hu, WJ Guan, Y Bi, W Zhang, L Li, B Zhang, Q Liu, Y Song, X Li, Z Duan, Q Zheng, Z Yang, J Liang, M Han, L Ruan, C Wu, Y Zhang, ZH Jia, NS Zhong. Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial. Phytomedicine 2020; 153242
https://doi.org/10.1016/j.phymed.2020.153242 pmid: 32425361
18 The State Council Information Office of the People’s Republic of China. The State Council Information Office held a conference on the important role of Chinese medicine in the prevention and treatment COVID-19 and related effective drugs. 2020. (in Chinese)
19 KT Yao, MH Liu, X Li, JH Huang, HB Cai. Retrospective clinical analysis of traditional Chinese medicine Lianhua Qingwen granule in treating new coronavirus pneumonia. Chin J Exp Tradit Med Form (Zhongguo Shi Yan Fang Ji Xue Za Zhi) 2020; 26(11): 8–12 (in Chinese)
20 D Cheng, Y Li. Clinical analysis and typical case report of 54 patients with COVID-19 treated by Lianhua Gingwen granule. World Chinese Medicine 2020; 15(2): 150–154
21 DZ Cheng, WJ Wang, Y Li, XD Wu, B Zhou, QY Song. Analysis of the efficacy of Chinese medicine Lianhua Qingwen granule in 51 patients with COVID-19: a multicenter retrospective study. Tianjin J Tradit Chin Med (Tianjin Zhong Yi Yao Za Zhi) 2020; [Epub ahead of print] (in Chinese)
22 RF Li, YL Hou, JC Huang, WQ Pan, QH Ma, YX Shi, CF Li, J Zhao, ZH Jia, HM Jiang, K Zheng, SX Huang, J Dai, XB Li, XT Hou, L Wang, NS Zhong, ZF Yang. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacol Res 2020; 156: 104761
https://doi.org/10.1016/j.phrs.2020.104761 pmid: 32205232
23 C Duan. WG Xia, CJ Zheng, GB Sun, ZL Li, QL Li, P Li, HL Zhang, FW Yang, BL Zhang, QQ Liu. Clinical observation of Jinhua Qinggan granule in treating COVID-19. J Tradit Chin Med (Zhong Yi Za Zhi) 2020; [Epub ahead of print] (in Chinese)
24 PY Gong, YJ Guo, XP Li, N Wang, J Gu. Research on potential drugs of Jinhua Qinggan granule for preventing and treating COVID-19 based on network pharmacology and pharmacodynamic research. Chin Tradit Herb Drugs (Zhong Cao Yao) 2020; [Epub ahead of print] (in Chinese)
25 Y Song, C Yao, Y Yao, H Han, X Zhao, K Yu, L Liu, Y Xu, Z Liu, Q Zhou, Y Wang, Z Ma, Y Zheng, D Wu, Z Tang, M Zhang, S Pan, Y Chai, Y Song, J Zhang, L Pan, Y Liu, H Yu, X Yu, H Zhang, X Wang, Z Du, X Wan, Y Tang, Y Tian, Y Zhu, H Wang, X Yan, Z Liu, B Zhang, N Zhong, H Shang, C Bai. XueBiJing Injection versus placebo for critically ill patients with severe community-acquired pneumonia: a randomized controlled trial. Crit Care Med 2019; 47(9): e735–e743
https://doi.org/10.1097/CCM.0000000000003842 pmid: 31162191
26 National Administration of Traditional Chinese Medicine. Huashi Baidu granule: ancient and innovative wisdom of traditional Chinese medicine. 2020. (in Chinese)
27 National Administration of Traditional Chinese Medicine. Progress in screening research on effective prescriptions of traditional Chinese medicine. 2020. (in Chinese)
28 National Administration of Traditional Chinese Medicine. Qingfei Paidu decoction had good feedback. 2020. (in Chinese)
29 Y Wang, X Li, JH Zhang, R Xue, JY Qian, XH Zhang, H Zhang, QQ Liu, XH Fan, JY Cheng, BL Zhang. Study on the mechanism of Xuanfei Baidu decoction in treating COVID-19 based on network pharmacology. Chin J Chin Materia Medica (Zhongguo Zhong Yao Za Zhi) 2020; 45(10):2249–2256 (in Chinese)
[1] Xiaoguang Xu, Wei Zhang, Mingquan Guo, Chenlu Xiao, Ziyu Fu, Shuting Yu, Lu Jiang, Shengyue Wang, Yun Ling, Feng Liu, Yun Tan, Saijuan Chen. Integrated analysis of gut microbiome and host immune responses in COVID-19[J]. Front. Med., 2022, 16(2): 263-275.
[2] Yi Zhang, Haocheng Zhang, Wenhong Zhang. SARS-CoV-2 variants, immune escape, and countermeasures[J]. Front. Med., 2022, 16(2): 196-207.
[3] Yiming Shao, Yingqi Wu, Yi Feng, Wenxin Xu, Feng Xiong, Xinxin Zhang. SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic[J]. Front. Med., 2022, 16(2): 185-195.
[4] Wei Zhang, Xiaoguang Xu, Ziyu Fu, Jian Chen, Saijuan Chen, Yun Tan. PathogenTrack and Yeskit: tools for identifying intracellular pathogens from single-cell RNA-sequencing datasets as illustrated by application to COVID-19[J]. Front. Med., 2022, 16(2): 251-262.
[5] Qiaoli Shi, Fei Xia, Qixin Wang, Fulong Liao, Qiuyan Guo, Chengchao Xu, Jigang Wang. Discovery and repurposing of artemisinin[J]. Front. Med., 2022, 16(1): 1-9.
[6] Jing Wang, Zequn Lu, Meng Jin, Ying Wang, Kunming Tian, Jun Xiao, Yimin Cai, Yanan Wang, Xu Zhang, Tao Chen, Zhi Yao, Chunguang Yang, Renli Deng, Qiang Zhong, Xiongbo Deng, Xin Chen, Xiang-ping Yang, Gonghong Wei, Zhihua Wang, Jianbo Tian, Xiao-ping Chen. Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study[J]. Front. Med., 2022, 16(1): 111-125.
[7] Huai-yu Wang, Suyuan Peng, Zhanghui Ye, Pengfei Li, Qing Li, Xuanyu Shi, Rui Zeng, Ying Yao, Fan He, Junhua Li, Liu Liu, Shuwang Ge, Xianjun Ke, Zhibin Zhou, Gang Xu, Ming-hui Zhao, Haibo Wang, Luxia Zhang, Erdan Dong. Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension[J]. Front. Med., 2022, 16(1): 102-110.
[8] Zehong Huang, Yingying Su, Tianying Zhang, Ningshao Xia. A review of the safety and efficacy of current COVID-19 vaccines[J]. Front. Med., 2022, 16(1): 39-55.
[9] Yuntao Zhang, Yunkai Yang, Niu Qiao, Xuewei Wang, Ling Ding, Xiujuan Zhu, Yu Liang, Zibo Han, Feng Liu, Xinxin Zhang, Xiaoming Yang. Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization in Chinese adults[J]. Front. Med., 2022, 16(1): 93-101.
[10] Li Ni, Zheng Wen, Xiaowen Hu, Wei Tang, Haisheng Wang, Ling Zhou, Lujin Wu, Hong Wang, Chang Xu, Xizhen Xu, Zhichao Xiao, Zongzhe Li, Chene Li, Yujian Liu, Jialin Duan, Chen Chen, Dan Li, Runhua Zhang, Jinliang Li, Yongxiang Yi, Wei Huang, Yanyan Chen, Jianping Zhao, Jianping Zuo, Jianping Weng, Hualiang Jiang, Dao Wen Wang. Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial[J]. Front. Med., 2021, 15(5): 704-717.
[11] Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang. Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium in inflammation caused by SARS-CoV-2[J]. Front. Med., 2021, 15(4): 638-643.
[12] Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie. Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections[J]. Front. Med., 2021, 15(4): 644-648.
[13] Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu. The “Traditional Chinese medicine regulating liver regeneration” treatment plan for reducing mortality of patients with hepatitis B-related liver failure based on real-world clinical data[J]. Front. Med., 2021, 15(3): 495-505.
[14] Dongsheng Wang, Binqing Fu, Zhen Peng, Dongliang Yang, Mingfeng Han, Min Li, Yun Yang, Tianjun Yang, Liangye Sun, Wei Li, Wei Shi, Xin Yao, Yan Ma, Fei Xu, Xiaojing Wang, Jun Chen, Daqing Xia, Yubei Sun, Lin Dong, Jumei Wang, Xiaoyu Zhu, Min Zhang, Yonggang Zhou, Aijun Pan, Xiaowen Hu, Xiaodong Mei, Haiming Wei, Xiaoling Xu. Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial[J]. Front. Med., 2021, 15(3): 486-494.
[15] Junnan Liang, Guannan Jin, Tongtong Liu, Jingyuan Wen, Ganxun Li, Lin Chen, Wei Wang, Yuwei Wang, Wei Liao, Jia Song, Zeyang Ding, Xiao-ping Chen, Bixiang Zhang. Clinical characteristics and risk factors for mortality in cancer patients with COVID-19[J]. Front. Med., 2021, 15(2): 264-274.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed