Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

doi:10.1007/s11515-012-1220-4

Front Biol

2012, Vol. 7

Issue (3) : 267-276 https://doi.org/10.1007/s11515-012-1220-4

REVIEW

Distinct roles for ERK1 and ERK2 in pathophysiology of CNS

Chen Guang YU(

)

Spinal Cord and Brain Injury Research Center and Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA

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Abstract

Mitogen-activated protein kinases ERK1 and ERK2 have been implicated in various pathophysiological events of the CNS, but their specific roles in cell processes under physiologic and pathological conditions remain to be determined. ERK1/2 was originally identified as a kinase activity that mediates neuronal survival and neuroprotection, but it was subsequently found that ERK1/2 also plays a critical role in neurodegeneration. This dichotomy makes it difficult to target ERK1/2 for neuroprotection. Accumulating evidence suggests that ERK1 and ERK2 may play distinct functions in a variety of cell fate decisions. In this review, I summarize recent evidence for distinct roles for individual ERK isoforms in pathophysiology of the CNS.

Keywords ERK isoform cell death cell proliferation neurodegeneration neuroprotection

Corresponding Author(s): YU Chen Guang,Email:cyu4@uky.edu

Issue Date: 01 June 2012

Cite this article:

Chen Guang YU. Distinct roles for ERK1 and ERK2 in pathophysiology of CNS[J]. Front Biol, 2012, 7(3): 267-276.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-012-1220-4
https://academic.hep.com.cn/fib/EN/Y2012/V7/I3/267

Fig.1 A diagram summarizing recent evidence for distinct functions for individual ERK isoforms in pathophysiology of the CNS.

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