The role of GSK3beta in the development of the central nervous system

doi:10.1007/s11515-012-1222-2

Front Biol

2012, Vol. 7

Issue (3) : 212-220 https://doi.org/10.1007/s11515-012-1222-2

REVIEW

The role of GSK3beta in the development of the central nervous system

Jia LUO(

)

Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA

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Abstract

Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine kinase. It is particularly abundant in the developing central nervous system (CNS). Since GSK3β has diverse substrates ranging from metabolic/signaling proteins and structural proteins to transcription factors, it is involved in many developmental events in the immature brain, such as neurogenesis, neuronal migration, differentiation and survival. The activity of GSK3β is developmentally regulated and is affected by various environmental/cellular insults, such as deprivation of nutrients/trophic factors, oxidative stress and endoplasmic reticulum stress. Abnormalities in GSK3β activity may disrupt CNS development. Therefore, GSK3β is a critical signaling protein that regulates brain development. It may also determine neuronal susceptibility to damages caused by various environmental insults.

Keywords development differentiation neurogenesis proliferation

Corresponding Author(s): LUO Jia,Email:jialuo888@uky.edu

Issue Date: 01 June 2012

Cite this article:

Jia LUO. The role of GSK3beta in the development of the central nervous system[J]. Front Biol, 2012, 7(3): 212-220.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-012-1222-2
https://academic.hep.com.cn/fib/EN/Y2012/V7/I3/212

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