Metabolism is regulated by protein acetylation

doi:10.1007/s11515-011-1126-6

Front Biol

2011, Vol. 6

Issue (3) : 213-218 https://doi.org/10.1007/s11515-011-1126-6

REVIEW

Metabolism is regulated by protein acetylation

Wei XU, Shimin ZHAO(

)

School of Life Sciences, Fudan University, Shanghai 200433, China

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Abstract

Lysine acetylation, first identified in histones, was initially thought to be a posttranslational modification occuring only in eukaryotic cells that controlled gene transcription either via remodeling chromatin or altering the transcriptional machinery. Recent studies, however, have shown that acetylation is a well-conserved metabolic regulatory mechanism that plays critical roles in regulating and coordinating cell metabolism. Acetylation regulates metabolism through controlling gene transcription, altering the metabolic enzymes activity and possibly other functional aspects, of metabolic enzymes. In this review, we provide an overview of the roles and significance of acetylation in metabolic regulation.

Keywords acetylation metabolism regulation

Corresponding Author(s): ZHAO Shimin,Email:zhaosm@fudan.edu.cn, vivi830706@gmail.com

Issue Date: 01 June 2011

Cite this article:

Wei XU,Shimin ZHAO. Metabolism is regulated by protein acetylation[J]. Front Biol, 2011, 6(3): 213-218.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-011-1126-6
https://academic.hep.com.cn/fib/EN/Y2011/V6/I3/213

Tab.1 Known lysine deacetylases (KDAC)

Tab.2 Known lysine acetylases (KAT)

Fig.1 Evolvement of acetylation.

Fig.2 Acetylation involves in multiple cellular functions.

Tab.3 Known metabolic genes that regulated by acetylation

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