Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

doi:10.1007/s11684-023-1043-5

Front. Med.

2023, Vol. 17

Issue (6) : 1030-1046 https://doi.org/10.1007/s11684-023-1043-5

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

Dong Wei¹, Yusang Xie^2,^3,⁴, Xuefei Liu^2,^3,⁴, Rong Chen^2,^3,⁴, Min Zhou^2,^3,⁴, Xinxin Zhang¹, Jieming Qu^2,^3,⁴(

)

¹. Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
². Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
³. Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
⁴. Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

Keywords coronavirus disease 2019 SARS-CoV-2 epidemiology clinical features

Corresponding Author(s): Jieming Qu

Just Accepted Date: 28 November 2023 Online First Date: 27 December 2023 Issue Date: 06 February 2024

Cite this article:

Dong Wei,Yusang Xie,Xuefei Liu, et al. Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China[J]. Front. Med., 2023, 17(6): 1030-1046.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-023-1043-5
https://academic.hep.com.cn/fmd/EN/Y2023/V17/I6/1030

Fig.1 Trend of COVID-19 epidemics in the world. (A) Accumulation of amino acid mutations in the S1 subunit of SARS-CoV-2 between December 2019 and May 2023, generated by nextstrain.org. (B) Unrooted phylogenetic tree of main SARS-CoV-2 variants, generated by nextstrain.org. (C) Frequency of SARS-CoV-2 lineages over time during the past three years in the world.

Fig.2 Four stages of COVID-19 epidemic in China and the dynamic of the confirmed infection cases during past three years. All data were obtained from China’s State Council Information (Available at the website of National Health Commission of the People’s Republic of China).

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