Strength and fatigue properties of three-step sintered dense nanocrystal hydroxyapatite bioceramics

doi:10.1007/s11706-013-0205-9

Front Mater Sci

2013, Vol. 7

Issue (2) : 190-195 https://doi.org/10.1007/s11706-013-0205-9

COMMUNICATION

Strength and fatigue properties of three-step sintered dense nanocrystal hydroxyapatite bioceramics

Wen-Guang GUO^1,2, Zhi-Ye QIU¹, Han CUI², Chang-Ming WANG², Xiao-Jun ZHANG², In-Seop LEE³, Yu-Qi DONG⁴(

), Fu-Zhai CUI¹(

)

1. School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; 2. Beijing Allgens Medical Science and Technology Co., Ltd., Beijing 100085, China; 3. Institute of Natural Science and Atomic-scale Surface Science Research Center, Yonsei University, Seoul 120-749, Korea; 4. Department of Orthopedics, Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China

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Abstract

Dense hydroxyapatite (HA) ceramic is a promising material for hard tissue repair due to its unique physical properties and biologic properties. However, the brittleness and low compressive strength of traditional HA ceramics limited their applications, because previous sintering methods produced HA ceramics with crystal sizes greater than nanometer range. In this study, nano-sized HA powder was employed to fabricate dense nanocrystal HA ceramic by high pressure molding, and followed by a three-step sintering process. The phase composition, microstructure, crystal dimension and crystal shape of the sintered ceramic were examined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Mechanical properties of the HA ceramic were tested, and cytocompatibility was evaluated. The phase of the sintered ceramic was pure HA, and the crystal size was about 200 nm. The compressive strength and elastic modulus of the HA ceramic were comparable to human cortical bone, especially the good fatigue strength overcame brittleness of traditional sintered HA ceramics. Cell attachment experiment also demonstrated that the ceramics had a good cytocompatibility.

Keywords nanocrystal hydroxyapatite ceramic three-step sintering mechanical property fatigue strength cytocompatibility

Corresponding Author(s): DONG Yu-Qi,Email:dyq001@gmail.com (Y.Q.D); CUI Fu-Zhai,Email:cuifz@mail.tsinghua.edu.cn (F.Z.C.)

Issue Date: 05 June 2013

Cite this article:

Wen-Guang GUO,Zhi-Ye QIU,Han CUI, et al. Strength and fatigue properties of three-step sintered dense nanocrystal hydroxyapatite bioceramics[J]. Front Mater Sci, 2013, 7(2): 190-195.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-013-0205-9
https://academic.hep.com.cn/foms/EN/Y2013/V7/I2/190

Fig.1 XRD patterns of HA powder and HA ceramic prepared by three-step method.

Tab.1 Crystal sizes of HA raw powder and the sintered dense ceramic

Fig.2 The relationship between grain size and relative density during the sintering.

Fig.3 SEM images of nanocrystal of the HA ceramic on the surface and the fracture section.

Tab.2 Mechanical property comparisons between nanocrystal HA ceramic and human cortical bone

Fig.4 Position-cycles curve of HA ceramic fatigue test: the maximum position curve (a); the minimum position curve (b).

Fig.5 Load-displacement curve of the HA ceramic sample after the fatigue test.

Fig.6 SEM images of MC3T3-E1 cells on the HA ceramic and the PEEK.

1	Guo X, Xiao P, Liu J, . Fabrication of nanostructured hydroxyapatite via hydrothermal synthesis and spark plasma sintering. Journal of the American Ceramic Society , 2005, 88(4): 1026-1029
2	Chen I W, Wang X H. Sintering dense nanocrystalline ceramics without final-stage grain growth. Nature , 2000, 404(6774): 168-171
3	Zhao H S, Wang G C, Hu S P, . In vitro biomimetic construction of hydroxyapatite-porcine acellular dermal matrix composite scaffold for MC3T3-E1 preosteoblast culture. Tissue Engineering Part A , 2011, 17(5-6): 765-776
4	Sadighpour L, Geramipanah F, Raeesi B. In vitro mechanical tests for modern dental ceramics. Journal of Dentistry of Tehran University of Medical Sciences , 2006, 3(3): 143-152
5	Nakahira A, Tamai M, Aritani H, . Biocompatibility of dense hydroxyapatite prepared using an SPS process. Journal of Biomedical Materials Research , 2002, 62(4): 550-557
6	Meyers M A, Chen P-Y, Lin A Y-M, . Biological materials: Structure and mechanical properties. Progress in Materials Science , 2008, 53(1): 1-206
7	Gu Y W, Khor K A, Cheang P. Bone-like apatite layer formation on hydroxyapatite prepared by spark plasma sintering (SPS). Biomaterials , 2004, 25(18): 4127-4134
8	Joschek S, Nies B, Krotz R, . Chemical and physicochemical characterization of porous hydroxyapatite ceramics made of natural bone. Biomaterials , 2000, 21(16): 1645-1658
9	Kusmanto F, Walker G, Gan Q, . Development of composite tissue scaffolds containing naturally sourced mircoporous hydroxyapatite. Chemical Engineering Journal , 2008, 139(2): 398-407
10	Deville S, Saiz E, Tomsia A P. Freeze casting of hydroxyapatite scaffolds for bone tissue engineering. Biomaterials , 2006, 27(32): 5480-5489
11	Wen S, Van D. Grain boundary in some nano-materials. Ceramics International , 1995, 21(2): 109-112
12	Suchanek W, Yashima M, Kakihana M, . Hydroxyapatite ceramics with selected sintering additives. Biomaterials , 1997, 18(13): 923-933
13	Aronov D, Karlov A, Rosenman G. Hydroxyapatite nanoceramics: Basic physical properties and biointerface modification. Journal of the European Ceramic Society , 2007, 27(13-15): 4181-4186
14	Yoon B H, Park C S, Kim H E, . In-situ fabrication of porous hydroxyapatite (HA) scaffolds with dense shells by freezing HA/camphene slurry. Materials Letters , 2008, 62(10-11): 1700-1703
15	Omori M, Onoki T, Hashida T, . Low temperature synthesis of hydroxyapatite from CaHPO₄·H₂O and Ca(OH)₂ based on effect of the spark plasma system (SPS). Ceramics International , 2006, 32(6): 617-621
16	Miao X, Tan D M, Li J, . Mechanical and biological properties of hydroxyapatite/tricalcium phosphate scaffolds coated with poly(lactic-co-glycolic acid). Acta Biomaterialia , 2008, 4(3): 638-645
17	He L H, Standard O C, Huang T T Y, . Mechanical behaviour of porous hydroxyapatite. Acta Biomaterialia , 2008, 4(3): 577-586
18	Werner J, Linner-Krcmar B, Friess W, . Mechanical properties and in vitro cell compatibility of hydroxyapatite ceramics with graded pore structure. Biomaterials , 2002, 23(21): 4285-4294
19	Chen B, Zhang T, Zhang J, . Microstructure and mechanical properties of hydroxyapatite obtained by gel-casting process. Ceramics International , 2008, 34(2): 359-364
20	Kumar R, Prakash K H, Cheang P, . Microstructure and mechanical properties of spark plasma sintered zirconia-hydroxyapatite nano-composite powders. Acta Materialia , 2005, 53(8): 2327-2335
21	Fellah B H, Gauthier O, Weiss P, . Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model. Biomaterials , 2008, 29(9): 1177-1188
22	Kalita S J, Bhatt H A. Nanocrystalline hydroxyapatite doped with magnesium and zinc: Synthesis and characterization. Materials Science and Engineering C , 2007, 27(4): 837-848
23	Chen Q Z, Wong C T, Lu W W, . Strengthening mechanisms of bone bonding to crystalline hydroxyapatite in vivo. Biomaterials , 2004, 25(18): 4243-4254

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