Antibacterial hydroxyapatite coatings on titanium dental implants

doi:10.1007/s11706-023-0628-x

Front. Mater. Sci.

2023, Vol. 17

Issue (1) : 230628 https://doi.org/10.1007/s11706-023-0628-x

REVIEW ARTICLE

Antibacterial hydroxyapatite coatings on titanium dental implants

Ziming Liao¹, Jingxuan Li¹, Yimeng Su¹, Fenyan Miao¹, Xiumei Zhang¹, Yu Gu¹, Jingjing Du^2,³(

), Ruiqiang Hang⁴(

), Yan Wei^1,³, Weiyi Chen^1,³, Di Huang^1,³(

)

¹. Research Center for Nano-Biomaterials & Regenerative Medicine, Department of Biomedical Engineering, College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
². Analytical & Testing Center, Hainan University, Haikou 570028, China
³. Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering, Taiyuan 030032, China
⁴. Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China

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Abstract

Titanium and its alloys are often used as substrates for dental implants due to their excellent mechanical properties and good biocompatibility. However, their ability to bind to neighboring bone is limited due to the lack of biological activity. At the same time, they show poor antibacterial ability which can easily cause bacterial infection and chronic inflammation, eventually resulting in implant failure. The preparation of composite hydroxyapatite coatings with antibacterial ability can effectively figure out these concerns. In this review, the research status and development trends of antibacterial hydroxyapatite coatings constructed on titanium and its alloys are analyzed and reviewed. This review may provide valuable reference for the preparation and application of high-performance and multi-functional dental implant coatings in the future.

Keywords composite dental implant hydroxyapatite titanium antibacterial

Corresponding Author(s): Jingjing Du,Ruiqiang Hang,Di Huang

About author:

Changjian Wang and Zhiying Yang contributed equally to this work.

Issue Date: 06 March 2023

Cite this article:

Ziming Liao,Jingxuan Li,Yimeng Su, et al. Antibacterial hydroxyapatite coatings on titanium dental implants[J]. Front. Mater. Sci., 2023, 17(1): 230628.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-023-0628-x
https://academic.hep.com.cn/foms/EN/Y2023/V17/I1/230628

Fig.1 (a) Schematic diagram of antibacterial methods and possible applications, and (b)(c)(d) schematic diagram of the antibacterial principle of metal NPs. Reproduced with permission from Refs. [30–32].

Fig.2 Schematic diagram of antibacterial HA coatings on Ti implants prepared by one-step and multi-step methods to kill bacteria and promote osteogenic differentiation.

Fig.3 (a) Ag inhomogeneous agglomeration under the action of an electric field. Reproduced with permission from Ref. [51]. (b) Ag is uniformly distributed without agglomeration after adding CS, and (c) Ag release rate under CS confinement. Reproduced with permission from Refs. [33,52].

Fig.4 (a) The flow chart of electrochemical loading of ZnO. Reproduced with permission from Ref. [60]. (b) SEM images of the coatings made by PEO at scale bars of 10 μm (i) and 5 μm (ii); SEM images of the MRSA strain cultured on uncoated and coated Ti samples at the scale bar of 5 μm (inset: 1 μm) (iii). Reproduced with permission from Ref. [68].

Fig.5 (a) The production scheme of HA?GO?COL composite coating on Ti 16Nb alloy surface, and (b) the schematic diagram of coating combined. Reproduced with permission from Ref. [76].

Fig.6 (a)(b)(c) The schematic diagram of coating preparation by sol-gel method. Reproduced with permission from Ref. [86]. (d) Schematic diagram of the antibacterial mechanism of F ions. Reproduced with permission from Ref. [90].

Fig.7 (a) The schematic diagram of suspension plasma spraying and its different antibacterial abilities at different powers, and (b) the schematic diagram of the coating prepared by the LENS^TM method and its release of Ag ions and its antibacterial effect. Reproduced with permission from Refs. [98?99].

Fig.8 (a) The schematic diagram of hybrid complexation with phosphate ion. Reproduced with permission from Ref. [120], and (b) the schematic diagram of the polymer brush grafted antimicrobial peptide on HA nanorods. Reproduced with permission from Ref. [121].

Tab.1 Advantages and disadvantages of common multi-step methods for preparing composite antibacterial HA coatings [125–127]

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