Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

doi:10.1007/s11706-023-0641-0

Front. Mater. Sci.

2023, Vol. 17

Issue (2) : 230641 https://doi.org/10.1007/s11706-023-0641-0

RESEARCH ARTICLE

Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment

Fangling Li^1,², Xiaoman Han³, Dongdong Cao⁴, Junxia Yin^1,², Li Chen^1,², Dongmei Li⁴, Lin Cui⁴, Zhiyong Liu^1,²(

), Xuhong Guo^1,^2,⁵(

)

¹. School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China
². Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi 832003, China
³. School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China
⁴. School of Medicine, Shihezi University, Shihezi 832003, China
⁵. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

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Abstract

Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.

Keywords heat preservation hemostasis antifouling antibacterial wound dressing

Corresponding Author(s): Zhiyong Liu,Xuhong Guo

Issue Date: 19 April 2023

Cite this article:

Fangling Li,Xiaoman Han,Dongdong Cao, et al. Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment[J]. Front. Mater. Sci., 2023, 17(2): 230641.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-023-0641-0
https://academic.hep.com.cn/foms/EN/Y2023/V17/I2/230641

Scheme1 Schematic diagram of the preparation and performance of aerogel dressings.

Fig.1 Fourier transform infrared spectra of P and OP.

Fig.2 SEM images of PDMS-Ag NW-CB: (a) Section of PDMS-Ag NW-CB; (b)(c) PDMS-Ag NW(drop)-CB prepared by drop coating of Ag NW and magnified images; (d)(e) PDMS-Ag NW(spray)-CB prepared by spraying Ag NW and magnified images; (f) PDMS layer of PDMS-Ag NW(drop)-CB.

Fig.3 Infrared transmittance patterns of CB, PDMS-Ag NW(drop)-CB, PDMS-Ag NW(drop)-CB, and Ag NW(drop)-CB.

Fig.4 Infrared thermal imaging comparison of CB, Ag NW-CB, and PDMS-Ag NW-CB.

Fig.5 Contact angle test plots: (a) contact angle of CB with water; (b)(c) contact angles of PDMS-Ag NW-CB with water and sheep blood, respectively; (d)(e) macroscopic images of the surface of PDMS-Ag NW-CB without and after dripping sheep blood, respectively.

Fig.6 Comparison of macroscopic inhibition zone effects of CB and PDMS-Ag NW-CB: (a)(b) macro map of inhibition zones of CB on E. coil and S. aureus; (c)(d) macro map of inhibition zones of PDMS-Ag NW-CB on E. coli and S. aureus; (e) statistical chart of the diameter of the inhibition zone; (f) hemolysis rate test chart of aerogel dressings. PBS is the negative control, and 0.1% TritonX-100 is the positive control. Scale bar: 1 cm.

Fig.7 Cytocompatibility of aerogel dressings: (a) cell viability of L929 cells incubated in different concentrations of PDMS-Ag NW-CB leaching solution; (b)(c) cell morphology map of L929 cells co-cultured with aerogel dressing leaching solution for 24 h.

Fig.8 Whole blood adhesion results of PDMS-Ag NW-CB: (a) whole blood coagulation absorbance values of CB and PDMS-Ag NW-CB; (b)(c) SEM image and magnification of platelet adhesion of PDMS-Ag NW-CB.

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