Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

doi:10.15302/J-FASE-2018222

Front. Agr. Sci. Eng.

2019, Vol. 6

Issue (1) : 28-32 https://doi.org/10.15302/J-FASE-2018222

REVIEW

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI¹, Qin PAN¹, Shuai YU¹, Na LI¹, Shulin CHEN¹, Kuldip SIDHU²(

), Jinlian HUA¹(

)

¹. College of Veterinary Medicine/Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling 712100, China
². Centre for Healthy Brain Ageing, UNSW Medicine, Randwick NSW 2031, Australia

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Abstract

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogonia or oocytes. However, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs). These two stages can be completely implemented with mouse cells. However, authentic porcine iPSCs have not been established. Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs. This knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency in farm species.

Keywords pig pluripotent stem cells primordial germ cells reprogramming

Corresponding Author(s): Kuldip SIDHU,Jinlian HUA

Just Accepted Date: 16 April 2018 Online First Date: 16 May 2018 Issue Date: 25 February 2019

Cite this article:

Qijing LEI,Qin PAN,Shuai YU, et al. Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review[J]. Front. Agr. Sci. Eng. , 2019, 6(1): 28-32.

URL:

https://academic.hep.com.cn/fase/EN/10.15302/J-FASE-2018222
https://academic.hep.com.cn/fase/EN/Y2019/V6/I1/28

Tab.1 Differentiation potential of pig pluripotent stem cells

Fig.1 Differentiation fate of pig pluripotent stem cells

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