|
|
|
Corrosion and bone response of magnesium implants
after surface modification by heat-self-assembled monolayer |
| Jia-Cheng GAO1,Li-Ying QIAO1,Ren-Long XIN2, |
| 1.National Engineering
Center for Magnesium Alloy, Chongqing University, Chongqing 400044,
China；College of Material
Science and Engineering, Chongqing University, Chongqing 400045, China; 2.College of Material
Science and Engineering, Chongqing University, Chongqing 400045, China; |
|
|
|
|
Abstract The corrosion degradation behavior and in vivo test of 4N-Mg after surface modification by heat-self-assembled monolayer (HSAM) were studied in this paper. Comprehensive techniques were used to analyze the corrosion process, corrosion rate and corrosion mecha-nism. The Mg samples with and without modifications were embedded in the thigh bones of white rabbits, and TC4 was used as the control. The concentration of Mg2+ ion in blood were analyzed after 2, 6, and 12 weeks of implantation. Then the specimens were analyzed by scanning electron microscope (SEM), and tissue slices were observed by optical microscope. The results show that the modified Mg had better corrosion resistance. The in vivo study confirmed that the magnesium concentration in blood was in the normal scale, and the Mg have good bone inducement and showed excellent capabilty of contact with bone. After implantations for a few weeks, the new bone obviously mineralizes on the interface between the modified Mg and bone. The untreated magnesium corroded faster than the HSAM treated magnesium in vivo. All the results indicated that Mg showed better biocompatibility and the capacity of inducing new bone due to HSAM had an effect on controlling the corrsion rate of Mg.
|
| Keywords
magnesium
biomaterials
surface modification
biocompatibility
|
|
Issue Date: 05 June 2010
|
|
|
McBride E D. Absorbable metal in bone surgery. Journal of the American Medical Association, 1938, 111(27): 2464–2467
|
|
Znamenskii M S. Metallic osteosynthesis by means of an apparatus madeof resorbing metal. Khirurgiia, 1945, 12: 60–63
|
|
McCord C P. Chemical gas gangrene from metallic magnesium. Industrial Medicine, 1942, 1(2): 71–79
|
|
Kuwahara H, Al-Abdullat Y, Mazaki N, et al. Precipitation ofmagnesium apatite on pure magnesium surface during immersing in Hank’ssolution. Materials Transactions, 2001, 42(7): 1317–1321
doi: 10.2320/matertrans.42.1317
|
|
Li L, Gao J, Wang Y. Evaluation of cyto-toxicity and corrosionbehavior of alkali-treated magnesium in simulated body fluid. Surface and Coating Technology, 2004, 185(1): 92–98
doi: 10.1016/j.surfcoat.2004.01.004
|
|
Gao J C, Xue Y, Qiao L Y, et al. Surface modification of magnesiumwith rare earth conversion films for biomedical protection. Materials Science Forum, 2007, 546―549: 601–604
|
|
Song Y W, Shan D Y, Han E H. Electrodeposition of hydroxyapatite coatingon AZ91D magnesium alloy for biomaterial application. Materials Letters, 2008, 62(17―18): 3276–3279
doi: 10.1016/j.matlet.2008.02.048
|
|
Xu L, Pan F, Yu G, et al. In vitro and in vivo evaluation of the surface bioactivityof a calcium phosphate coated magnesium alloy. Biomaterials, 2009, 30(8): 1512–1523
doi: 10.1016/j.biomaterials.2008.12.001
|
|
Zhang E, Xu L, Yang K. Formation by ion plating of Ti-coatingon pure Mg for biomedical applications. Scripta Materialia, 2005, 53(5): 523–527
doi: 10.1016/j.scriptamat.2005.05.009
|
|
Liu C, Xin Y, Tian X, et al. Corrosion resistance of titaniumion implanted AZ91 magnesium alloy. Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films, 2007, 25(2): 334–339
doi: 10.1116/1.2699371
|
|
Liu C, Xin Y, Tian X, et al. Corrosion behavior of AZ91 magnesiumalloy treated by plasma immersion ion implantation and depositionin artificial physiological fluids. Thin Solid Films, 2007, 516(2―4): 422–427
doi: 10.1016/j.tsf.2007.05.048
|
|
Yang J X, Cui F Z, Lee I-S, et al. Ion-beam assisted depositedC–N coating on magnesium alloys. Surface and Coatings Technology, 2008, 202(22―23): 5737–5741
doi: 10.1016/j.surfcoat.2008.06.116
|
|
Hiromoto S, Shishido T, Yamamoto A, et al. Precipitation controlof calcium phosphate on pure magnesium by anodization. Corrosion Science, 2008, 50(10): 2906–2913
doi: 10.1016/j.corsci.2008.08.013
|
|
Hu J, Guan S, Zhang C, et al. Corrosion protection of AZ31magnesium alloy by a TiO2 coating prepared by LPD method. Surface and Coatings Technology, 2009, 203(14): 2017–2020
doi: 10.1016/j.surfcoat.2009.01.036
|
|
Witte F, Kaese V, Haferkamp H, et al. In vivo corrosion of four magnesium alloys and the associated bone response. Biomaterials, 2005, 26(17): 3557–3563
doi: 10.1016/j.biomaterials.2004.09.049
|
|
Duygulu O, Kaya R A, Oktay G, et al. Investigation on thepotential of magnesium alloy AZ31 as a bone implant. Materials Science Forum, 2007, 546―549: 421–424
|
|
Huang J, Ren Y, Zhang B, et al. Study on biocompatility of magnesiumand its alloys. Rare Metal Materials andEngineering, 2007, 36(6): 1102–1105 (in Chinese)
|
|
Huang J, Yang K, Ren Y, et al. Experimental study on earlystage of mg implanted in animals. Rare Metal Materials and Engineering, 2008, 37(4): 629–632 (in Chinese)
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
