BMP signaling pathway and spinal cord development

doi:10.1007/s11515-011-1178-7

Front Biol

2012, Vol. 7

Issue (1) : 24-29 https://doi.org/10.1007/s11515-011-1178-7

REVIEW

BMP signaling pathway and spinal cord development

Zhihui XIE, Nengyin SHENG, Naihe JING(

)

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

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Abstract

The development of spinal cord is a precisely and sequentially regulated process, which is controlled by signaling pathways and transcription factors in each stage. Overwhelming data have shown the essential roles of BMP signaling in different stages of this developmental process. It is also clear that the proper functions of BMP signaling require its cross-talk with several other signaling pathways including Notch, Wnt and retinoic acid (RA) pathways. Here, we highlight the recent advancement in understanding the roles of BMP signaling during neurogenesis, neural tube patterning, axon development and glial differentiation in the spinal cord, and emphasize its integrations with other pathways during these processes.

Keywords BMP spinal cord neurogenesis patterning glia

Corresponding Author(s): JING Naihe,Email:njing@sibs.ac.cn

Issue Date: 01 February 2012

Cite this article:

Zhihui XIE,Nengyin SHENG,Naihe JING. BMP signaling pathway and spinal cord development[J]. Front Biol, 2012, 7(1): 24-29.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-011-1178-7
https://academic.hep.com.cn/fib/EN/Y2012/V7/I1/24

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