Metabolic control of adult neural stem cell behavior

doi:10.1007/s11515-015-1349-z

Front. Biol.

2015, Vol. 10

Issue (2) : 100-106 https://doi.org/10.1007/s11515-015-1349-z

MINI-REVIEW

Metabolic control of adult neural stem cell behavior

Marlen Knobloch(

),Sebastian Jessberger(

)

Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland

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Abstract

Neural stem cells generate new neurons throughout life in distinct regions of the mammalian brain. This process, called adult neurogenesis, is important for tissue homeostasis and physiological brain function. In addition, failing or altered neurogenesis has been associated with a number of diseases such as major depression and epilepsy. Thus, understanding the molecular mechanisms governing the neurogenic process in the adult brain may enable future therapeutic approaches to target neural stem/progenitor cells (NSPCs) and their progeny to ameliorate disease symptoms and/or disease progression. Recently, the control of cellular metabolism has emerged as a regulator of NSPC activity in the adult brain. Here we review recent findings that attempt to describe stage-specific modulations of metabolism to ensure proper neurogenesis and suggest future avenues of research aiming to understand how metabolism affects NSPC behavior.

Keywords adult neurogenesis metabolic switch quiescence proliferation differentiation

Corresponding Author(s): Marlen Knobloch,Sebastian Jessberger

Just Accepted Date: 11 February 2015 Issue Date: 06 May 2015

Cite this article:

Marlen Knobloch,Sebastian Jessberger. Metabolic control of adult neural stem cell behavior[J]. Front. Biol., 2015, 10(2): 100-106.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-015-1349-z
https://academic.hep.com.cn/fib/EN/Y2015/V10/I2/100

Fig.1 Schematic representation of metabolic pathways active in adult NSPCs and their progeny. Question marks indicate putative active pathways that need to be confirmed. SGZ, subgranular zone; DGC, dentate granule cell layer.

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