Histogram analysis of laser speckle contrast image for cerebral blood flow monitoring

doi:10.1007/s12200-015-0493-z

Front. Optoelectron.

2015, Vol. 8

Issue (2) : 187-194 https://doi.org/10.1007/s12200-015-0493-z

RESEARCH ARTICLE

Histogram analysis of laser speckle contrast image for cerebral blood flow monitoring

Arkady S. ABDURASHITOV¹(

), Vladislav V. LYCHAGOV¹, Olga A. SINDEEVA¹, Oxana V. SEMYACHKINA-GLUSHKOVSKAYA¹, Valery V. TUCHIN^1,^2,³

¹. National Research Saratov State University, Saratov 410012, Russia
². Institute of Precise Mechanics and Control RAS, Saratov 410028, Russia
³. Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk 634050, Russia

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Abstract

Laser speckle contrast imaging (LSCI) is a powerful tool for blood flow mapping. In this paper, we described a simple algorithm based on histogram analysis of laser speckle contrast image to provide rapid differentiation between macro- and microcirculations. The algorithm was successfully verified by the study of blood flow in rat cortex under functional activation.

Keywords laser speckle contrast imaging (LSCI) histogram analysis cerebral blood flow (CBF) rat

Corresponding Author(s): Arkady S. ABDURASHITOV

Just Accepted Date: 11 February 2015 Online First Date: 17 April 2015 Issue Date: 24 June 2015

Cite this article:

Arkady S. ABDURASHITOV,Vladislav V. LYCHAGOV,Olga A. SINDEEVA, et al. Histogram analysis of laser speckle contrast image for cerebral blood flow monitoring[J]. Front. Optoelectron., 2015, 8(2): 187-194.

URL:

https://academic.hep.com.cn/foe/EN/10.1007/s12200-015-0493-z
https://academic.hep.com.cn/foe/EN/Y2015/V8/I2/187

Fig.1 Typical speckle contrast image

Fig.2 Histogram analysis of speckle image. (a) Multiple ROIs in speckle contrast image; (b) normalized histograms of these ROIs

Fig.3 Two consecutive frames of the time lapse measurements. Green block denotes statically overlaid ROI, whereas purple block is defined by correlation-based motion tracker

Fig.4 Cross-correlations between selection and the next frame in series. Purple block shows new ROI coordinates with respect to maximum of cross-correlation function; green block is a statically overlaid ROI

Fig.5 Results of time lapse measurements performed with statically overlaid ROI (a) and with correlation based motion tracker (b)

Fig.6 Typical example of changes of mean arterial pressure (a) and CBF after bolus injection of phenylephrine in three doses (0.25, 0.5, and 1?µg/kg) in normotensive (b) and hypertensive (c) rats

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