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Frontiers in Biology

ISSN 1674-7984

ISSN 1674-7992(Online)

CN 11-5892/Q

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Front Biol    2013, Vol. 8 Issue (4) : 369-376    https://doi.org/10.1007/s11515-013-1265-z
REVIEW
The perinucleolar compartment associates with malignancy
Yiping WEN1,2, Chen WANG1, Sui HUANG1()
1. Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, IL 60611, USA; 2. College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China
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Abstract

The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.
Keywords PNC      cancer      nuclear substructure      gene expression regulation      structure and function     
Corresponding Author(s): HUANG Sui,Email:s-huang2@northwestern.edu   
Issue Date: 01 August 2013
 Cite this article:   
Yiping WEN,Chen WANG,Sui HUANG. The perinucleolar compartment associates with malignancy[J]. Front Biol, 2013, 8(4): 369-376.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-013-1265-z
https://academic.hep.com.cn/fib/EN/Y2013/V8/I4/369
Fig.1  RNase MRP RNA and PTB colocalize in the PNC at the nucleolar periphery. In situ hybridizations using specific oligo probe show perinucleolar enrichment of the RNA (left panel, arrows) which is colocalized (right panel, arrows) with a bright PTB immunolabeling signal (middle panel, arrows). The bar= 10 μm.
Fig.2  Schematic diagram summarizes that PNCs form as the consequence of transformation. Its formation signifies that cancer cells become capable of metastasis. PNC prevalence, thus, can be used as a cancer marker for anti-cancer drug development.
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